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Items: 1 to 20 of 98

1.

Internal dynamics control activation and activity of the autoinhibited Vav DH domain.

Li P, Martins IR, Amarasinghe GK, Rosen MK.

Nat Struct Mol Biol. 2008 Jun;15(6):613-8. doi: 10.1038/nsmb.1428. Epub 2008 May 18.

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4.

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK.

Cell. 2010 Jan 22;140(2):246-56. doi: 10.1016/j.cell.2009.12.033.

5.

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.

Rapley J, Tybulewicz VL, Rittinger K.

EMBO Rep. 2008 Jul;9(7):655-61. doi: 10.1038/embor.2008.80. Epub 2008 May 30.

6.

Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J.

J Biol Chem. 2007 May 4;282(18):13813-23. Epub 2007 Mar 2.

7.

Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.

Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P.

J Mol Biol. 2008 Jul 25;380(5):828-43. doi: 10.1016/j.jmb.2008.05.024. Epub 2008 May 17.

8.

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

Das B, Shu X, Day GJ, Han J, Krishna UM, Falck JR, Broek D.

J Biol Chem. 2000 May 19;275(20):15074-81.

9.

Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.

Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W.

J Biol Chem. 2006 Dec 15;281(50):38257-65. Epub 2006 Oct 18.

10.

Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex.

Brooun A, Foster SA, Chrencik JE, Chien EY, Kolatkar AR, Streiff M, Ramage P, Widmer H, Weckbecker G, Kuhn P.

Protein Expr Purif. 2007 May;53(1):51-62. Epub 2006 Dec 5.

11.

Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.

Heo J, Thapar R, Campbell SL.

Biochemistry. 2005 May 3;44(17):6573-85.

PMID:
15850391
12.

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.

Yohe ME, Rossman K, Sondek J.

Biochemistry. 2008 Jul 1;47(26):6827-39. doi: 10.1021/bi702543p. Epub 2008 Jun 7.

13.

Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity.

Palmby TR, Abe K, Der CJ.

J Biol Chem. 2002 Oct 18;277(42):39350-9. Epub 2002 Aug 12.

14.

Autoinhibition mechanism of proto-Dbl.

Bi F, Debreceni B, Zhu K, Salani B, Eva A, Zheng Y.

Mol Cell Biol. 2001 Mar;21(5):1463-74.

15.

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.

Liu X, Wang H, Eberstadt M, Schnuchel A, Olejniczak ET, Meadows RP, Schkeryantz JM, Janowick DA, Harlan JE, Harris EA, Staunton DE, Fesik SW.

Cell. 1998 Oct 16;95(2):269-77.

16.

Oligomerization of DH domain is essential for Dbl-induced transformation.

Zhu K, Debreceni B, Bi F, Zheng Y.

Mol Cell Biol. 2001 Jan;21(2):425-37.

17.

The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin.

Ahmad KF, Lim WA.

PLoS One. 2010 Jun 24;5(6):e11291. doi: 10.1371/journal.pone.0011291.

18.

Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.

Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM.

J Biol Chem. 2012 Apr 13;287(16):13137-58. doi: 10.1074/jbc.M111.320010. Epub 2012 Feb 18.

20.

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

Crespo P, Bustelo XR, Aaronson DS, Coso OA, Lopez-Barahona M, Barbacid M, Gutkind JS.

Oncogene. 1996 Aug 1;13(3):455-60.

PMID:
8760286
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