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Items: 1 to 20 of 268


A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes.

Boonen M, Rezende de Castro R, Cuvelier G, Hamer I, Jadot M.

Biochem J. 2008 Sep 15;414(3):431-40. doi: 10.1042/BJ20071626.


Lysosomal targeting of the CLN7 membrane glycoprotein and transport via the plasma membrane require a dileucine motif.

Steenhuis P, Herder S, Gelis S, Braulke T, Storch S.

Traffic. 2010 Jul 1;11(7):987-1000. doi: 10.1111/j.1600-0854.2010.01073.x. Epub 2010 Apr 16.


Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

Marks MS, Woodruff L, Ohno H, Bonifacino JS.

J Cell Biol. 1996 Oct;135(2):341-54.


An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1.

Piccirillo R, Palmisano I, Innamorati G, Bagnato P, Altimare D, Schiaffino MV.

J Cell Sci. 2006 May 15;119(Pt 10):2003-14. Epub 2006 Apr 18.


The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif.

Cherqui S, Kalatzis V, Trugnan G, Antignac C.

J Biol Chem. 2001 Apr 20;276(16):13314-21. Epub 2001 Jan 9.


AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

Kyttälä A, Yliannala K, Schu P, Jalanko A, Luzio JP.

J Biol Chem. 2005 Mar 18;280(11):10277-83. Epub 2004 Dec 13.


Involvement of dileucine motifs in the internalization and degradation of the insulin receptor.

Haft CR, Klausner RD, Taylor SI.

J Biol Chem. 1994 Oct 21;269(42):26286-94. Erratum in: J Biol Chem 1995 Dec 15;270(50):30235.


The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors.

Dennes A, Cromme C, Suresh K, Kumar NS, Eble JA, Hahnenkamp A, Pohlmann R.

J Biol Chem. 2005 Apr 1;280(13):12849-57. Epub 2005 Jan 21.


The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.

Obermüller S, Kiecke C, von Figura K, Höning S.

J Cell Sci. 2002 Jan 1;115(Pt 1):185-94.


Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells.

Ihrke G, Bruns JR, Luzio JP, Weisz OA.

EMBO J. 2001 Nov 15;20(22):6256-64.


The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.

Sandoval IV, Arredondo JJ, Alcalde J, Gonzalez Noriega A, Vandekerckhove J, Jimenez MA, Rico M.

J Biol Chem. 1994 Mar 4;269(9):6622-31.

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