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Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors.

Bernstein NK, Karimi-Busheri F, Rasouli-Nia A, Mani R, Dianov G, Glover JN, Weinfeld M.

Anticancer Agents Med Chem. 2008 May;8(4):358-67. Review.


DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer.

Allinson SL.

Future Oncol. 2010 Jun;6(6):1031-42. doi: 10.2217/fon.10.40.


Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination.

Karimi-Busheri F, Rasouli-Nia A, Allalunis-Turner J, Weinfeld M.

Cancer Res. 2007 Jul 15;67(14):6619-25.


Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining.

Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC.

EMBO J. 2002 Jun 3;21(11):2827-32.


Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, Weinfeld M, Durocher D.

EMBO J. 2004 Oct 1;23(19):3874-85. Epub 2004 Sep 23.


The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.

Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN.

Mol Cell. 2005 Mar 4;17(5):657-70.


Cadmium and copper inhibit both DNA repair activities of polynucleotide kinase.

Whiteside JR, Box CL, McMillan TJ, Allinson SL.

DNA Repair (Amst). 2010 Jan 2;9(1):83-9. doi: 10.1016/j.dnarep.2009.11.004. Epub 2009 Dec 3.


XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.

Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW.

Cell. 2001 Jan 12;104(1):107-17.


NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.

Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK.

DNA Repair (Amst). 2006 Dec 9;5(12):1439-48. Epub 2006 Sep 18.


Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.

Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A, Mereniuk TR, Ahrens A, Koshy JM, Rasouli-Nia A, Pasarj P, Holmes CF, Rininsland F, Hall DG, Weinfeld M.

Cancer Res. 2009 Oct 1;69(19):7739-46. doi: 10.1158/0008-5472.CAN-09-1805. Epub 2009 Sep 22.


Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks.

Henner WD, Grunberg SM, Haseltine WA.

J Biol Chem. 1983 Dec 25;258(24):15198-205.


Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase.

Galburt EA, Pelletier J, Wilson G, Stoddard BL.

Structure. 2002 Sep;10(9):1249-60.


AP endonuclease-independent DNA base excision repair in human cells.

Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK.

Mol Cell. 2004 Jul 23;15(2):209-20.


Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.

Audebert M, Salles B, Weinfeld M, Calsou P.

J Mol Biol. 2006 Feb 17;356(2):257-65. Epub 2005 Nov 28.


Sensitive nanochannel biosensor for T4 polynucleotide kinase activity and inhibition detection.

Lin L, Liu Y, Yan J, Wang X, Li J.

Anal Chem. 2013 Jan 2;85(1):334-40. doi: 10.1021/ac302875p. Epub 2012 Dec 13.


Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.

Rasouli-Nia A, Karimi-Busheri F, Weinfeld M.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):6905-10. Epub 2004 Apr 20.

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