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Items: 1 to 20 of 153

1.

Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.

Barile E, Borriello M, Di Pietro A, Doreau A, Fattorusso C, Fattorusso E, Lanzotti V.

Org Biomol Chem. 2008 May 21;6(10):1756-62. doi: 10.1039/b800485d. Epub 2008 Mar 28.

PMID:
18452010
2.

Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia.

Tao HW, Hao XJ, Liu PP, Zhu WM.

Arch Pharm Res. 2008 Dec;31(12):1547-51. doi: 10.1007/s12272-001-2149-3. Epub 2008 Dec 20.

PMID:
19099222
3.

Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A.

Corea G, Fattorusso E, Lanzotti V, Motti R, Simon PN, Dumontet C, Di Pietro A.

J Med Chem. 2004 Feb 12;47(4):988-92.

PMID:
14761200
5.

Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.

Jiao W, Dong W, Li Z, Deng M, Lu R.

Bioorg Med Chem. 2009 Jul 1;17(13):4786-92. doi: 10.1016/j.bmc.2009.04.041. Epub 2009 Apr 24.

PMID:
19443229
6.

Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead.

Corea G, Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Appendino G, Ballero M, Simon PN, Dumontet C, Di Pietro A.

J Med Chem. 2003 Jul 17;46(15):3395-402.

PMID:
12852769
7.

Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.

Duarte N, Varga A, Cherepnev G, Radics R, Molnár J, Ferreira MJ.

Bioorg Med Chem. 2007 Jan 1;15(1):546-54. Epub 2006 Oct 10.

PMID:
17035027
8.
9.

Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.

Corea G, Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Appendino G, Ballero M, Simon PN, Dumontet C, Di Pietro A.

Bioorg Med Chem. 2003 Nov 17;11(23):5221-7.

PMID:
14604686
10.

Structure-activity relationships for euphocharacins A-L, a new series of jatrophane diterpenes, as inhibitors of cancer cell P-glycoprotein.

Corea G, Fattorusso E, Lanzotti V, Motti R, Simon PN, Dumontet C, Di Pietro A.

Planta Med. 2004 Jul;70(7):657-65.

PMID:
15254859
11.

New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells.

Duarte N, Gyémánt N, Abreu PM, Molnár J, Ferreira MJ.

Planta Med. 2006 Feb;72(2):162-8.

PMID:
16491453
12.

Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia.

Hua J, Liu YC, Jing SX, Luo SH, Li SH.

Nat Prod Commun. 2015 Dec;10(12):2037-9.

PMID:
26882659
13.

Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.

Valente I, Reis M, Duarte N, Serly J, Molnár J, Ferreira MJ.

J Nat Prod. 2012 Nov 26;75(11):1915-21. doi: 10.1021/np3004003. Epub 2012 Oct 25.

PMID:
23098168
14.

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Appendino G, Della Porta C, Conseil G, Sterner O, Mercalli E, Dumontet C, Di Pietro A.

J Nat Prod. 2003 Jan;66(1):140-2.

PMID:
12542364
15.

[Studies on macrocyclic jatrophane diterpenes of Euphorbia kansui].

Chen YL, Yuan D, Xu X, Fu HZ.

Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(15):1836-9. Chinese.

PMID:
19007010
16.

Cytotoxic diterpenoids from Euphorbia helioscopia.

Lu ZQ, Guan SH, Li XN, Chen GT, Zhang JQ, Huang HL, Liu X, Guo DA.

J Nat Prod. 2008 May;71(5):873-6. doi: 10.1021/np0706163. Epub 2008 Mar 6.

PMID:
18321057
17.

Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells.

Duarte N, Járdánházy A, Molnár J, Hilgeroth A, Ferreira MJ.

Bioorg Med Chem. 2008 Oct 15;16(20):9323-30. doi: 10.1016/j.bmc.2008.08.071. Epub 2008 Aug 31.

PMID:
18824363
18.

Diterpenes inhibiting NO production from Euphorbia helioscopia.

Chen H, Wang H, Yang B, Jin DQ, Yang S, Wang M, Xu J, Ohizumi Y, Guo Y.

Fitoterapia. 2014 Jun;95:133-8. doi: 10.1016/j.fitote.2014.03.010. Epub 2014 Mar 16.

PMID:
24641945
19.

Ingol and ingenol diterpenes from the aerial parts of Euphorbia royleana and their antiangiogenic activities.

Li XL, Li Y, Wang SF, Zhao YL, Liu KC, Wang XM, Yang YP.

J Nat Prod. 2009 Jun;72(6):1001-5. doi: 10.1021/np800816n.

PMID:
19438253
20.

Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay.

Pan Q, Ip FC, Ip NY, Zhu HX, Min ZD.

J Nat Prod. 2004 Sep;67(9):1548-51.

PMID:
15387657
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