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Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

Ranganathan AC, Ojha S, Kourtidis A, Conklin DS, Aguirre-Ghiso JA.

Cancer Res. 2008 May 1;68(9):3260-8. doi: 10.1158/0008-5472.CAN-07-6215.


Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K.

J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6.


Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.

Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S.

Neoplasia. 2010 Jan;12(1):61-8.


ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.

Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, Koumenis C.

EMBO J. 2005 Oct 5;24(19):3470-81. Epub 2005 Sep 8.


The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.

Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR.

Mol Cell Biol. 2002 Jun;22(11):3864-74.


The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14.


Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation.

Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF, Aguirre-Ghiso JA.

PLoS One. 2007 Jul 18;2(7):e615.


Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15920-5. Epub 2002 Nov 22.


Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis.

Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B.

J Neurosci. 2013 Apr 3;33(14):5980-91. doi: 10.1523/JNEUROSCI.1636-12.2013.


Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.

Yacoub A, Park MA, Gupta P, Rahmani M, Zhang G, Hamed H, Hanna D, Sarkar D, Lebedeva IV, Emdad L, Sauane M, Vozhilla N, Spiegel S, Koumenis C, Graf M, Curiel DT, Grant S, Fisher PB, Dent P.

Mol Cancer Ther. 2008 Feb;7(2):297-313. doi: 10.1158/1535-7163.MCT-07-2166.


Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG.

Mol Cell Biol. 2002 Nov;22(21):7405-16.


PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.

Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP.

Mol Endocrinol. 2011 Feb;25(2):315-26. doi: 10.1210/me.2010-0309. Epub 2010 Dec 30.


PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.

Iida K, Li Y, McGrath BC, Frank A, Cavener DR.

BMC Cell Biol. 2007 Aug 29;8:38.


EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes.

Zhang A, Zhang J, Sun P, Yao C, Su C, Sui T, Huang H, Cao X, Ge Y.

Neurosci Lett. 2010 Jun 30;478(1):32-6. doi: 10.1016/j.neulet.2010.04.062. Epub 2010 May 2.


PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

Rouschop KM, Dubois LJ, Keulers TG, van den Beucken T, Lambin P, Bussink J, van der Kogel AJ, Koritzinsky M, Wouters BG.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4622-7. doi: 10.1073/pnas.1210633110. Epub 2013 Mar 7.


Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D.

J Cell Biol. 2006 Jan 16;172(2):201-9.

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