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Nano Lett. 2008 May;8(5):1368-73. doi: 10.1021/nl080105g. Epub 2008 Apr 30.

Cell-specific integration of artificial organelles based on functionalized polymer vesicles.

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  • 1Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

Abstract

Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell.

PMID:
18444692
[PubMed - indexed for MEDLINE]
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