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Results: 1 to 20 of 215

1.

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.

Kim HE, Jiang X, Du F, Wang X.

Mol Cell. 2008 Apr 25;30(2):239-47. doi: 10.1016/j.molcel.2008.03.014. Erratum in: Mol Cell. 2008 Dec 26;32(6):888.

PMID:
18439902
[PubMed - indexed for MEDLINE]
Free Article
2.

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

Bao Q, Lu W, Rabinowitz JD, Shi Y.

Mol Cell. 2007 Jan 26;25(2):181-92.

PMID:
17244527
[PubMed - indexed for MEDLINE]
Free Article
3.

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.

Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR.

Nat Cell Biol. 2000 Aug;2(8):469-75.

PMID:
10934466
[PubMed - indexed for MEDLINE]
4.

Negative regulation of the Apaf-1 apoptosome by Hsp70.

Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES.

Nat Cell Biol. 2000 Aug;2(8):476-83.

PMID:
10934467
[PubMed - indexed for MEDLINE]
5.

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K.

J Biol Chem. 2004 May 7;279(19):19665-82. Epub 2004 Mar 1.

PMID:
14993223
[PubMed - indexed for MEDLINE]
Free Article
6.

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes.

Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ.

EMBO J. 2004 May 19;23(10):2134-45. Epub 2004 Apr 22.

PMID:
15103327
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.

Malet G, Martín AG, Orzáez M, Vicent MJ, Masip I, Sanclimens G, Ferrer-Montiel A, Mingarro I, Messeguer A, Fearnhead HO, Pérez-Payá E.

Cell Death Differ. 2006 Sep;13(9):1523-32. Epub 2005 Dec 9.

PMID:
16341125
[PubMed - indexed for MEDLINE]
Free Article
8.

A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome.

Reubold TF, Wohlgemuth S, Eschenburg S.

J Biol Chem. 2009 Nov 20;284(47):32717-24. doi: 10.1074/jbc.M109.014027. Epub 2009 Sep 30.

PMID:
19801675
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Intracellular K(+) inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release.

Karki P, Seong C, Kim JE, Hur K, Shin SY, Lee JS, Cho B, Park IS.

Cell Death Differ. 2007 Dec;14(12):2068-75. Epub 2007 Sep 21.

PMID:
17885667
[PubMed - indexed for MEDLINE]
Free Article
10.

Chemical-induced apoptosis: formation of the Apaf-1 apoptosome.

Cain K.

Drug Metab Rev. 2003 Nov;35(4):337-63. Review.

PMID:
14705865
[PubMed - indexed for MEDLINE]
11.

Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1.

Qi X, Wang L, Du F.

Biochemistry. 2010 Mar 9;49(9):1923-30. doi: 10.1021/bi9022329.

PMID:
20121050
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.

Kim HE, Du F, Fang M, Wang X.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17545-50. Epub 2005 Oct 26.

PMID:
16251271
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Jun kinase delays caspase-9 activation by interaction with the apoptosome.

Tran TH, Andreka P, Rodrigues CO, Webster KA, Bishopric NH.

J Biol Chem. 2007 Jul 13;282(28):20340-50. Epub 2007 May 4.

PMID:
17483091
[PubMed - indexed for MEDLINE]
Free Article
14.

Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.

Schafer ZT, Parrish AB, Wright KM, Margolis SS, Marks JR, Deshmukh M, Kornbluth S.

Cancer Res. 2006 Feb 15;66(4):2210-8.

PMID:
16489023
[PubMed - indexed for MEDLINE]
Free Article
15.

Heat-shock protein 70 antagonizes apoptosis-inducing factor.

Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger JM, Garrido C, Kroemer G.

Nat Cell Biol. 2001 Sep;3(9):839-43.

PMID:
11533664
[PubMed - indexed for MEDLINE]
16.

Apoptosome assembly.

Shi Y.

Methods Enzymol. 2008;442:141-56. doi: 10.1016/S0076-6879(08)01407-9.

PMID:
18662568
[PubMed - indexed for MEDLINE]
17.

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.

Lauber K, Appel HA, Schlosser SF, Gregor M, Schulze-Osthoff K, Wesselborg S.

J Biol Chem. 2001 Aug 10;276(32):29772-81. Epub 2001 May 31.

PMID:
11387322
[PubMed - indexed for MEDLINE]
Free Article
18.

Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome.

Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG.

Cell. 2006 Jun 30;125(7):1333-46.

PMID:
16814719
[PubMed - indexed for MEDLINE]
Free Article
19.

Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.

Piddubnyak V, Rigou P, Michel L, Rain JC, Geneste O, Wolkenstein P, Vidaud D, Hickman JA, Mauviel A, Poyet JL.

Cell Death Differ. 2007 Jun;14(6):1222-33. Epub 2007 Mar 23.

PMID:
17380155
[PubMed - indexed for MEDLINE]
Free Article
20.

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.

Wolf BB, Schuler M, Li W, Eggers-Sedlet B, Lee W, Tailor P, Fitzgerald P, Mills GB, Green DR.

J Biol Chem. 2001 Sep 7;276(36):34244-51. Epub 2001 Jun 27.

PMID:
11429402
[PubMed - indexed for MEDLINE]
Free Article

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