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Results: 1 to 20 of 96

1.

Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells.

Zhang H, Sachdev D, Wang C, Hubel A, Gaillard-Kelly M, Yee D.

Breast Cancer Res Treat. 2009 Mar;114(2):277-85. doi: 10.1007/s10549-008-0014-5. Epub 2008 Apr 17.

PMID:
18418709
[PubMed - indexed for MEDLINE]
2.

A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I.

Sachdev D, Li SL, Hartell JS, Fujita-Yamaguchi Y, Miller JS, Yee D.

Cancer Res. 2003 Feb 1;63(3):627-35.

PMID:
12566306
[PubMed - indexed for MEDLINE]
Free Article
3.
4.

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore.

Zhang H, Zeng X, Li Q, Gaillard-Kelly M, Wagner CR, Yee D.

Br J Cancer. 2009 Jul 7;101(1):71-9. doi: 10.1038/sj.bjc.6605103. Epub 2009 Jun 2.

PMID:
19491901
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

Zhang H, Pelzer AM, Kiang DT, Yee D.

Cancer Res. 2007 Jan 1;67(1):391-7.

PMID:
17210722
[PubMed - indexed for MEDLINE]
Free Article
6.

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D.

J Biol Chem. 2004 Feb 6;279(6):5017-24. Epub 2003 Nov 13.

PMID:
14615489
[PubMed - indexed for MEDLINE]
Free Article
7.

Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment.

Fagan DH, Uselman RR, Sachdev D, Yee D.

Cancer Res. 2012 Jul 1;72(13):3372-80. doi: 10.1158/0008-5472.CAN-12-0684. Epub 2012 May 9.

PMID:
22573715
[PubMed - indexed for MEDLINE]
Free Article
8.

The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.

Lisztwan J, Pornon A, Chen B, Chen S, Evans DB.

Breast Cancer Res. 2008;10(4):R56. doi: 10.1186/bcr2113. Epub 2008 Jul 8.

PMID:
18611244
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.

Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, Girnita A, Axelson M, Girnita L, Larsson O.

Oncogene. 2008 Mar 6;27(11):1629-38. Epub 2007 Sep 10.

PMID:
17828296
[PubMed - indexed for MEDLINE]
10.

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

Shang Y, Mao Y, Batson J, Scales SJ, Phillips G, Lackner MR, Totpal K, Williams S, Yang J, Tang Z, Modrusan Z, Tan C, Liang WC, Tsai SP, Vanderbilt A, Kozuka K, Hoeflich K, Tien J, Ross S, Li C, Lee SH, Song A, Wu Y, Stephan JP, Ashkenazi A, Zha J.

Mol Cancer Ther. 2008 Sep;7(9):2599-608. doi: 10.1158/1535-7163.MCT-07-2401.

PMID:
18790743
[PubMed - indexed for MEDLINE]
Free Article
11.

The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.

Sachdev D, Zhang X, Matise I, Gaillard-Kelly M, Yee D.

Oncogene. 2010 Jan 14;29(2):251-62. doi: 10.1038/onc.2009.316. Epub 2009 Oct 19.

PMID:
19838209
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.

Riedemann J, Takiguchi M, Sohail M, Macaulay VM.

Biochem Biophys Res Commun. 2007 Apr 13;355(3):707-14. Epub 2007 Feb 9.

PMID:
17307140
[PubMed - indexed for MEDLINE]
13.

Conjugated linoleic acid decreases mcf-7 human breast cancer cell growth and insulin-like growth factor-1 receptor levels.

Amarù DL, Field CJ.

Lipids. 2009 May;44(5):449-58. doi: 10.1007/s11745-009-3288-4. Epub 2009 Mar 6.

PMID:
19266226
[PubMed - indexed for MEDLINE]
14.

IGF1R signalling and its inhibition.

Riedemann J, Macaulay VM.

Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S33-43. Review.

PMID:
17259557
[PubMed - indexed for MEDLINE]
Free Article
15.

Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining.

Li-Shishido S, Watanabe TM, Tada H, Higuchi H, Ohuchi N.

Biochem Biophys Res Commun. 2006 Dec 8;351(1):7-13. Epub 2006 Oct 9.

PMID:
17055452
[PubMed - indexed for MEDLINE]
16.

Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.

Mukohara T, Shimada H, Ogasawara N, Wanikawa R, Shimomura M, Nakatsura T, Ishii G, Park JO, Jänne PA, Saijo N, Minami H.

Cancer Lett. 2009 Sep 8;282(1):14-24. doi: 10.1016/j.canlet.2009.02.056. Epub 2009 Apr 3.

PMID:
19345478
[PubMed - indexed for MEDLINE]
17.

Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells.

Dong A, Kong M, Ma Z, Qian J, Cheng H, Xu X.

Acta Biochim Biophys Sin (Shanghai). 2008 Jun;40(6):497-504.

PMID:
18535748
[PubMed - indexed for MEDLINE]
Free Article
18.

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E, Gee JM, Finlay P, Jones HE, Nicholson RI, Carboni J, Gottardis M, Pollak M, Dunn SE.

Cancer Res. 2008 Dec 15;68(24):10238-46. doi: 10.1158/0008-5472.CAN-08-2755.

PMID:
19074892
[PubMed - indexed for MEDLINE]
Free Article
19.

Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration.

de Blaquière GE, May FE, Westley BR.

Endocr Relat Cancer. 2009 Jun;16(2):635-47. doi: 10.1677/ERC-08-0216. Epub 2009 Mar 4.

PMID:
19261680
[PubMed - indexed for MEDLINE]
Free Article
20.

Epitope-specific mechanisms of IGF1R inhibition by ganitumab.

Calzone FJ, Cajulis E, Chung YA, Tsai MM, Mitchell P, Lu J, Chen C, Sun J, Radinsky R, Kendall R, Beltran PJ.

PLoS One. 2013;8(2):e55135. doi: 10.1371/journal.pone.0055135. Epub 2013 Feb 1.

PMID:
23383308
[PubMed - indexed for MEDLINE]
Free PMC Article

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