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Items: 1 to 20 of 124

1.

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.

Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS.

J Clin Invest. 2008 May;118(5):1712-26. doi: 10.1172/JCI34523.

2.

Age-related deregulation of Aire and peripheral tissue antigen genes in the thymic stroma of non-obese diabetic (NOD) mice is associated with autoimmune type 1 diabetes mellitus (DM-1).

Fornari TA, Donate PB, Macedo C, Marques MM, Magalhães DA, Passos GA.

Mol Cell Biochem. 2010 Sep;342(1-2):21-8. doi: 10.1007/s11010-010-0464-z. Epub 2010 Apr 23.

PMID:
20414703
3.

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice.

Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M.

J Immunol. 2005 Feb 15;174(4):1862-70.

4.

Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

Shikama N, Nusspaumer G, Holländer GA.

Endocrinol Metab Clin North Am. 2009 Jun;38(2):273-88, vii. doi: 10.1016/j.ecl.2009.01.011. Review.

PMID:
19328411
5.

Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype.

Hubert FX, Kinkel SA, Crewther PE, Cannon PZ, Webster KE, Link M, Uibo R, O'Bryan MK, Meager A, Forehan SP, Smyth GK, Mittaz L, Antonarakis SE, Peterson P, Heath WR, Scott HS.

J Immunol. 2009 Mar 15;182(6):3902-18. doi: 10.4049/jimmunol.0802124.

6.

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

Liston A, Gray DH, Lesage S, Fletcher AL, Wilson J, Webster KE, Scott HS, Boyd RL, Peltonen L, Goodnow CC.

J Exp Med. 2004 Oct 18;200(8):1015-26.

7.

Projection of an immunological self shadow within the thymus by the aire protein.

Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D.

Science. 2002 Nov 15;298(5597):1395-401. Epub 2002 Oct 10.

8.

Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.

Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS.

J Immunol. 2008 Sep 15;181(6):4072-9.

9.
10.

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.

Rizzi M, Ferrera F, Filaci G, Indiveri F.

Autoimmun Rev. 2006 Feb;5(2):145-7. Epub 2005 Sep 13. Review.

PMID:
16431348
11.

Aire regulates negative selection of organ-specific T cells.

Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC.

Nat Immunol. 2003 Apr;4(4):350-4. Epub 2003 Mar 3.

PMID:
12612579
12.

The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function.

Ruan QG, Tung K, Eisenman D, Setiady Y, Eckenrode S, Yi B, Purohit S, Zheng WP, Zhang Y, Peltonen L, She JX.

J Immunol. 2007 Jun 1;178(11):7173-80.

13.

Functional analysis of SAND mutations in AIRE supports dominant inheritance of the G228W mutation.

Ilmarinen T, Eskelin P, Halonen M, Rüppell T, Kilpikari R, Torres GD, Kangas H, Ulmanen I.

Hum Mutat. 2005 Oct;26(4):322-31.

PMID:
16114041
14.

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.

Oftedal BE, Hellesen A, Erichsen MM, Bratland E, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG, Sewell WA, Sozaeva LS, Zayats T, Haugarvoll K, Orlova EM, Haavik J, Johansson S, Knappskog PM, Løvås K, Wolff AS, Abramson J, Husebye ES.

Immunity. 2015 Jun 16;42(6):1185-96. doi: 10.1016/j.immuni.2015.04.021.

15.

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen.

DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi RR, Fong L, Anderson MS.

J Exp Med. 2006 Nov 27;203(12):2727-35. Epub 2006 Nov 20. Erratum in: J Exp Med. 2007 Jan 22;204(1):203. Caspi, Rachel [corrected to Caspi, Rachel R].

16.

Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1).

Ströbel P, Murumägi A, Klein R, Luster M, Lahti M, Krohn K, Schalke B, Nix W, Gold R, Rieckmann P, Toyka K, Burek C, Rosenwald A, Müller-Hermelink HK, Pujoll-Borrell R, Meager A, Willcox N, Peterson P, Marx A.

J Pathol. 2007 Apr;211(5):563-71.

PMID:
17334980
17.

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.

Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4583-7. Epub 2007 Mar 6.

18.

The role of Aire in clonal selection.

Taniguchi RT, Anderson MS.

Immunol Cell Biol. 2011 Jan;89(1):40-4. doi: 10.1038/icb.2010.132. Epub 2010 Nov 16. Review.

19.

Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity.

Fierabracci A.

Autoimmun Rev. 2011 Jan;10(3):137-43. doi: 10.1016/j.autrev.2010.08.019. Epub 2010 Sep 17. Review.

PMID:
20850570
20.

Polyglandular autoimmune syndrome type I - a novel AIRE mutation in a North American patient.

Huibregtse KE, Wolfgram P, Winer KK, Connor EL.

J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1257-60. doi: 10.1515/jpem-2013-0328.

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