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Results: 1 to 20 of 121

1.

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M.

J Clin Invest. 2008 May;118(5):1846-57. doi: 10.1172/JCI32503.

PMID:
18382765
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
[PubMed - indexed for MEDLINE]
3.

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

PMID:
23139294
[PubMed - indexed for MEDLINE]
Free Article
4.

Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1082-90. doi: 10.1152/ajplung.00199.2009. Epub 2009 Oct 2.

PMID:
19801450
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation.

Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M.

Circulation. 2007 Mar 13;115(10):1275-84. Epub 2007 Mar 5.

PMID:
17339547
[PubMed - indexed for MEDLINE]
Free Article
6.

Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.

Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK, Morrell NW.

Circulation. 2009 Feb 3;119(4):566-76. doi: 10.1161/CIRCULATIONAHA.108.821504. Epub 2009 Jan 19.

PMID:
19153267
[PubMed - indexed for MEDLINE]
Free Article
7.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

PMID:
23525442
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.

Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L740-54. Epub 2003 May 9.

PMID:
12740218
[PubMed - indexed for MEDLINE]
Free Article
9.

Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.

Yang J, Li X, Li Y, Southwood M, Ye L, Long L, Al-Lamki RS, Morrell NW.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L312-21. doi: 10.1152/ajplung.00054.2013. Epub 2013 Jun 14.

PMID:
23771884
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.

Ihida-Stansbury K, McKean DM, Lane KB, Loyd JE, Wheeler LA, Morrell NW, Jones PL.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L694-702. Epub 2006 Jun 16.

PMID:
16782755
[PubMed - indexed for MEDLINE]
Free Article
11.

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW.

Circ Res. 2010 Jul 23;107(2):252-62. doi: 10.1161/CIRCRESAHA.109.209940. Epub 2010 Jun 3.

PMID:
20522807
[PubMed - indexed for MEDLINE]
Free Article
12.

Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension.

Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y.

Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.

PMID:
16361357
[PubMed - indexed for MEDLINE]
Free Article
13.

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension.

Yang J, Davies RJ, Southwood M, Long L, Yang X, Sobolewski A, Upton PD, Trembath RC, Morrell NW.

Circ Res. 2008 May 23;102(10):1212-21. doi: 10.1161/CIRCRESAHA.108.173567. Epub 2008 Apr 24.

PMID:
18436795
[PubMed - indexed for MEDLINE]
Free Article
14.

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

Upton PD, Davies RJ, Tajsic T, Morrell NW.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1135-45. doi: 10.1165/rcmb.2012-0470OC.

PMID:
23937428
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A.

J Biol Chem. 2007 Dec 21;282(51):37244-55. Epub 2007 Oct 17.

PMID:
17947237
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.

Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY, Rabinovitch M.

J Clin Invest. 2011 Sep;121(9):3735-46. doi: 10.1172/JCI43382. Epub 2011 Aug 8.

PMID:
21821917
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW.

Circ Res. 2005 May 27;96(10):1053-63. Epub 2005 Apr 21.

PMID:
15845886
[PubMed - indexed for MEDLINE]
Free Article
18.

Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.

Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1473-9. Epub 2007 Feb 23.

PMID:
17322283
[PubMed - indexed for MEDLINE]
Free Article
19.

Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.

Yu PB, Beppu H, Kawai N, Li E, Bloch KD.

J Biol Chem. 2005 Jul 1;280(26):24443-50. Epub 2005 May 9.

PMID:
15883158
[PubMed - indexed for MEDLINE]
Free Article
20.

BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.

Lagna G, Nguyen PH, Ni W, Hata A.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1059-67.

PMID:
17030903
[PubMed - indexed for MEDLINE]
Free Article
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