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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.

Guo B, Chang EY, Cheng G.

J Clin Invest. 2008 May;118(5):1680-90. doi: 10.1172/JCI33342.


Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE.

Isaksson M, Ardesjö B, Rönnblom L, Kämpe O, Lassmann H, Eloranta ML, Lobell A.

Eur J Immunol. 2009 Oct;39(10):2925-35. doi: 10.1002/eji.200839179.


Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.

Kanakasabai S, Chearwae W, Walline CC, Iams W, Adams SM, Bright JJ.

Immunology. 2010 Aug;130(4):572-88. doi: 10.1111/j.1365-2567.2010.03261.x. Epub 2010 Apr 6.


Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.

Fitzgerald DC, Fonseca-Kelly Z, Cullimore ML, Safabakhsh P, Saris CJ, Zhang GX, Rostami A.

J Immunol. 2013 Apr 1;190(7):3225-34. doi: 10.4049/jimmunol.1200141. Epub 2013 Mar 1.


Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation.

Zhang L, Yuan S, Cheng G, Guo B.

PLoS One. 2011;6(12):e28432. doi: 10.1371/journal.pone.0028432. Epub 2011 Dec 6.


Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH.

Immunity. 2009 Aug 21;31(2):331-41. doi: 10.1016/j.immuni.2009.08.001. Epub 2009 Aug 13.


Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.

Shinohara ML, Kim JH, Garcia VA, Cantor H.

Immunity. 2008 Jul 18;29(1):68-78. doi: 10.1016/j.immuni.2008.05.008.


Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling.

Raveney BJ, Oki S, Yamamura T.

PLoS One. 2013;8(2):e56595. doi: 10.1371/journal.pone.0056595. Epub 2013 Feb 21.


Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.

Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T.

J Clin Invest. 2007 Nov;117(11):3306-15.


Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U.

Immunity. 2008 May;28(5):675-86. doi: 10.1016/j.immuni.2008.03.011.


Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis.

Andersson A, Isaksson M, Wefer J, Norling A, Flores-Morales A, Rorsman F, Kämpe O, Harris RA, Lobell A.

PLoS One. 2008;3(11):e3682. doi: 10.1371/journal.pone.0003682. Epub 2008 Nov 10.


IFN-γ limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27.

Murugaiyan G, Beynon V, Pires Da Cunha A, Joller N, Weiner HL.

J Immunol. 2012 Dec 1;189(11):5277-83. doi: 10.4049/jimmunol.1200808. Epub 2012 Nov 2.


IFN-beta inhibits human Th17 cell differentiation.

Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S.

J Immunol. 2009 Oct 15;183(8):5418-27. doi: 10.4049/jimmunol.0803227. Epub 2009 Sep 25.


IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

Teige I, Treschow A, Teige A, Mattsson R, Navikas V, Leanderson T, Holmdahl R, Issazadeh-Navikas S.

J Immunol. 2003 May 1;170(9):4776-84.


Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis.

Murphy AC, Lalor SJ, Lynch MA, Mills KH.

Brain Behav Immun. 2010 May;24(4):641-51. doi: 10.1016/j.bbi.2010.01.014. Epub 2010 Feb 6.


T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.

Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C.

Nat Med. 2010 Apr;16(4):406-12. doi: 10.1038/nm.2110. Epub 2010 Mar 28.


IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.

Sonderegger I, Kisielow J, Meier R, King C, Kopf M.

Eur J Immunol. 2008 Jul;38(7):1833-8. doi: 10.1002/eji.200838511.


Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis.

Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI.

J Immunol. 2008 Jun 1;180(11):7097-101.


Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS.

Kalinke U, Prinz M.

Immunol Cell Biol. 2012 May;90(5):505-9. doi: 10.1038/icb.2012.8. Epub 2012 Mar 20. Review.


Therapeutic benefits of regulating inflammation in autoimmunity.

Nikoopour E, Schwartz JA, Singh B.

Inflamm Allergy Drug Targets. 2008 Sep;7(3):203-10. Review.

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