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Results: 1 to 20 of 139

1.

Impact of cholesterol level upon APP and BACE proximity and APP cleavage.

von Arnim CA, von Einem B, Weber P, Wagner M, Schwanzar D, Spoelgen R, Strauss WL, Schneckenburger H.

Biochem Biophys Res Commun. 2008 May 30;370(2):207-12. doi: 10.1016/j.bbrc.2008.03.047. Epub 2008 Mar 27.

PMID:
18374657
[PubMed - indexed for MEDLINE]
2.

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT.

J Cell Sci. 2003 Aug 15;116(Pt 16):3339-46. Epub 2003 Jun 26.

PMID:
12829747
[PubMed - indexed for MEDLINE]
Free Article
3.

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT.

J Biol Chem. 2005 May 6;280(18):17777-85. Epub 2005 Mar 4.

PMID:
15749709
[PubMed - indexed for MEDLINE]
Free Article
4.

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT.

J Neurosci. 2006 Sep 27;26(39):9913-22.

PMID:
17005855
[PubMed - indexed for MEDLINE]
Free Article
5.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.

J Neurosci. 2006 Jan 11;26(2):418-28.

PMID:
16407538
[PubMed - indexed for MEDLINE]
Free Article
6.

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.

J Neurochem. 2007 Feb;100(3):802-9.

PMID:
17156133
[PubMed - indexed for MEDLINE]
7.

A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.

Tanahashi H, Tabira T.

Neurosci Lett. 2007 Nov 27;428(2-3):103-8. Epub 2007 Sep 26.

PMID:
17961921
[PubMed - indexed for MEDLINE]
8.

Visualization of beta-secretase cleavage in living cells using a genetically encoded surface-displayed [corrected] FRET probe.

Lu J, Zhang Z, Yang J, Chu J, Li P, Zeng S, Luo Q.

Biochem Biophys Res Commun. 2007 Oct 12;362(1):25-30. Epub 2007 Aug 6. Erratum in: Biochem Biophys Res Commun. 2008 Aug 8;372(4):951.

PMID:
17698032
[PubMed - indexed for MEDLINE]
9.

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

Marquer C, Devauges V, Cossec JC, Liot G, Lécart S, Saudou F, Duyckaerts C, Lévêque-Fort S, Potier MC.

FASEB J. 2011 Apr;25(4):1295-305. doi: 10.1096/fj.10-168633. Epub 2011 Jan 21. Erratum in: FASEB J. 2012 Jan;26(1):468.

PMID:
21257714
[PubMed - indexed for MEDLINE]
Free Article
10.

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.

von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT.

J Cell Sci. 2004 Oct 15;117(Pt 22):5437-45. Epub 2004 Oct 5.

PMID:
15466887
[PubMed - indexed for MEDLINE]
Free Article
11.

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.

Harris B, Pereira I, Parkin E.

Brain Res. 2009 Nov 3;1296:203-15. doi: 10.1016/j.brainres.2009.07.105. Epub 2009 Aug 11.

PMID:
19679113
[PubMed - indexed for MEDLINE]
12.

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.

Liu K, Doms RW, Lee VM.

Biochemistry. 2002 Mar 5;41(9):3128-36.

PMID:
11863452
[PubMed - indexed for MEDLINE]
13.

Human beta-secretase (BACE) and BACE inhibitors: progress report.

John V.

Curr Top Med Chem. 2006;6(6):569-78. Review.

PMID:
16712492
[PubMed - indexed for MEDLINE]
14.

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.

Fischer F, Molinari M, Bodendorf U, Paganetti P.

J Neurochem. 2002 Mar;80(6):1079-88.

PMID:
11953458
[PubMed - indexed for MEDLINE]
15.

Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.

Kern A, Roempp B, Prager K, Walter J, Behl C.

J Biol Chem. 2006 Feb 3;281(5):2405-13. Epub 2005 Nov 22. Erratum in: J Biol Chem. 2006 May 5;281(18):13000.

PMID:
16303768
[PubMed - indexed for MEDLINE]
Free Article
16.

Evidence for dimeric BACE-mediated APP processing.

Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):21-7. doi: 10.1016/j.bbrc.2010.01.064. Epub 2010 Jan 25.

PMID:
20097169
[PubMed - indexed for MEDLINE]
17.

Dynamin 1 regulates amyloid generation through modulation of BACE-1.

Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D.

PLoS One. 2012;7(9):e45033. Epub 2012 Sep 14.

PMID:
23024787
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Degradation of BACE by the ubiquitin-proteasome pathway.

Qing H, Zhou W, Christensen MA, Sun X, Tong Y, Song W.

FASEB J. 2004 Oct;18(13):1571-3. Epub 2004 Aug 2.

PMID:
15289451
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

Human BACE forms dimers and colocalizes with APP.

Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G.

J Biol Chem. 2004 Sep 17;279(38):39710-7. Epub 2004 Jul 9.

PMID:
15247262
[PubMed - indexed for MEDLINE]
Free Article

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