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Results: 1 to 20 of 122

1.

Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.

Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN.

J Biol Chem. 2008 Jun 6;283(23):16135-46. doi: 10.1074/jbc.M710323200. Epub 2008 Mar 26.

PMID:
18367445
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket.

Zhou X, Chua TK, Tkaczuk KL, Bujnicki JM, Sivaraman J.

J Struct Biol. 2010 Mar;169(3):277-85. doi: 10.1016/j.jsb.2009.12.024. Epub 2010 Jan 4.

PMID:
20051267
[PubMed - indexed for MEDLINE]
3.

Structure and mechanism of spermidine synthases.

Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN.

Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22.

PMID:
17585781
[PubMed - indexed for MEDLINE]
4.

Spermine synthase.

Pegg AE, Michael AJ.

Cell Mol Life Sci. 2010 Jan;67(1):113-21. doi: 10.1007/s00018-009-0165-5. Epub 2009 Oct 27. Review.

PMID:
19859664
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Aminopropyltransferases: function, structure and genetics.

Ikeguchi Y, Bewley MC, Pegg AE.

J Biochem. 2006 Jan;139(1):1-9. Review.

PMID:
16428313
[PubMed - indexed for MEDLINE]
6.

Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.

Pegg AE, Borchardt RT, Coward JK.

Biochem J. 1981 Jan 15;194(1):79-89.

PMID:
7305994
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Crystal structure of Helicobacter pylori spermidine synthase: a Rossmann-like fold with a distinct active site.

Lu PK, Tsai JY, Chien HY, Huang H, Chu CH, Sun YJ.

Proteins. 2007 May 15;67(3):743-54.

PMID:
17357156
[PubMed - indexed for MEDLINE]
8.

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.

Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S.

J Mol Biol. 2007 Oct 12;373(1):167-77. Epub 2007 Aug 2.

PMID:
17822713
[PubMed - indexed for MEDLINE]
9.

Molecular cloning of a cDNA encoding human spermine synthase.

Korhonen VP, Halmekytö M, Kauppinen L, Myöhänen S, Wahlfors J, Keinänen T, Hyvönen T, Alhonen L, Eloranta T, Jänne J.

DNA Cell Biol. 1995 Oct;14(10):841-7.

PMID:
7546290
[PubMed - indexed for MEDLINE]
10.

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.

Sečkutė J, McCloskey DE, Thomas HJ, Secrist JA 3rd, Pegg AE, Ealick SE.

Protein Sci. 2011 Nov;20(11):1836-44. doi: 10.1002/pro.717. Epub 2011 Sep 15.

PMID:
21898642
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Studies of inhibition of rat spermidine synthase and spermine synthase.

Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.

Biochem J. 1980 May 1;187(2):419-28.

PMID:
7396856
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Crystal structures of Fms1 and its complex with spermine reveal substrate specificity.

Huang Q, Liu Q, Hao Q.

J Mol Biol. 2005 May 13;348(4):951-9.

PMID:
15843025
[PubMed - indexed for MEDLINE]
13.

The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis.

Montemayor EJ, Hoffman DW.

Biochemistry. 2008 Sep 2;47(35):9145-53. doi: 10.1021/bi8009357. Epub 2008 Aug 9.

PMID:
18690703
[PubMed - indexed for MEDLINE]
14.

Kinetic properties of spermine synthase from bovine brain.

Pajula RL.

Biochem J. 1983 Dec 1;215(3):669-76.

PMID:
6419729
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.

Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A.

Nat Struct Biol. 2002 Jan;9(1):27-31.

PMID:
11731804
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase.

Pegg AE, Coward JK, Talekar RR, Secrist JA 3rd.

Biochemistry. 1986 Jul 15;25(14):4091-7.

PMID:
3091070
[PubMed - indexed for MEDLINE]
17.

Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes.

Nguyen NT, Maurus R, Stokell DJ, Ayed A, Duckworth HW, Brayer GD.

Biochemistry. 2001 Nov 6;40(44):13177-87.

PMID:
11683626
[PubMed - indexed for MEDLINE]
18.

Putrescine N-methyltransferases--a structure-function analysis.

Teuber M, Azemi ME, Namjoyan F, Meier AC, Wodak A, Brandt W, Dräger B.

Plant Mol Biol. 2007 Apr;63(6):787-801. Epub 2007 Jan 14.

PMID:
17221359
[PubMed - indexed for MEDLINE]
19.

Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase.

Dufe VT, Lüersen K, Eschbach ML, Haider N, Karlberg T, Walter RD, Al-Karadaghi S.

FEBS Lett. 2005 Nov 7;579(27):6037-43. Epub 2005 Oct 5.

PMID:
16226262
[PubMed - indexed for MEDLINE]
Free Article
20.

Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors.

Shirahata A, Morohohi T, Fukai M, Akatsu S, Samejima K.

Biochem Pharmacol. 1991 Jan 15;41(2):205-12.

PMID:
1989632
[PubMed - indexed for MEDLINE]

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