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An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.

Selmecki A, Gerami-Nejad M, Paulson C, Forche A, Berman J.

Mol Microbiol. 2008 May;68(3):624-41. doi: 10.1111/j.1365-2958.2008.06176.x. Epub 2008 Mar 20.


Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.

Coste A, Selmecki A, Forche A, Diogo D, Bougnoux ME, d'Enfert C, Berman J, Sanglard D.

Eukaryot Cell. 2007 Oct;6(10):1889-904. Epub 2007 Aug 10.


Up-regulation of ERG11 gene among fluconazole-resistant Candida albicans generated in vitro: is there any clinical implication?

Ribeiro MA, Paula CR.

Diagn Microbiol Infect Dis. 2007 Jan;57(1):71-5. Epub 2006 Jul 11.


An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans.

Heilmann CJ, Schneider S, Barker KS, Rogers PD, Morschhäuser J.

Antimicrob Agents Chemother. 2010 Jan;54(1):353-9. doi: 10.1128/AAC.01102-09. Epub 2009 Nov 2.


Heterogeneous mechanisms of azole resistance in Candida albicans clinical isolates from an HIV-infected patient on continuous fluconazole therapy for oropharyngeal candidosis.

Martínez M, López-Ribot JL, Kirkpatrick WR, Bachmann SP, Perea S, Ruesga MT, Patterson TF.

J Antimicrob Chemother. 2002 Mar;49(3):515-24.


ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD.

Antimicrob Agents Chemother. 2008 Nov;52(11):3851-62. doi: 10.1128/AAC.00463-08. Epub 2008 Aug 18.


Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection.

Pancholi P, Park S, Perlin D, Kubin C, Della-Latta P.

J Clin Microbiol. 2004 Dec;42(12):5938-9.


Aneuploidy and isochromosome formation in drug-resistant Candida albicans.

Selmecki A, Forche A, Berman J.

Science. 2006 Jul 21;313(5785):367-70.


Drug resistance genes and trailing growth in Candida albicans isolates.

Lee MK, Williams LE, Warnock DW, Arthington-Skaggs BA.

J Antimicrob Chemother. 2004 Feb;53(2):217-24. Epub 2003 Dec 19.


Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.

MacCallum DM, Coste A, Ischer F, Jacobsen MD, Odds FC, Sanglard D.

Antimicrob Agents Chemother. 2010 Apr;54(4):1476-83. doi: 10.1128/AAC.01645-09. Epub 2010 Jan 19.


Investigation of mutations in Erg11 gene of fluconazole resistant Candida albicans isolates from Turkish hospitals.

Manastır L, Ergon MC, Yücesoy M.

Mycoses. 2011 Mar;54(2):99-104. doi: 10.1111/j.1439-0507.2009.01766.x.


Fcr1p inhibits development of fluconazole resistance in Candida albicans by abolishing CDR1 induction.

Shen H, An MM, Wang de J, Xu Z, Zhang JD, Gao PH, Cao YY, Cao YB, Jiang YY.

Biol Pharm Bull. 2007 Jan;30(1):68-73.


Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.

Feng LJ, Wan Z, Wang XH, Li RY, Liu W.

Chin Med J (Engl). 2010 Mar 5;123(5):544-8.


Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations.

Xu Y, Chen L, Li C.

J Antimicrob Chemother. 2008 Apr;61(4):798-804. doi: 10.1093/jac/dkn015. Epub 2008 Jan 24.


Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.

Wang H, Kong F, Sorrell TC, Wang B, McNicholas P, Pantarat N, Ellis D, Xiao M, Widmer F, Chen SC.

BMC Microbiol. 2009 Aug 14;9:167. doi: 10.1186/1471-2180-9-167.


Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

Morio F, Loge C, Besse B, Hennequin C, Le Pape P.

Diagn Microbiol Infect Dis. 2010 Apr;66(4):373-84. doi: 10.1016/j.diagmicrobio.2009.11.006. Review.


Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans.

Chen CG, Yang YL, Tseng KY, Shih HI, Liou CH, Lin CC, Lo HJ.

Fungal Genet Biol. 2009 Sep;46(9):714-20. doi: 10.1016/j.fgb.2009.06.003. Epub 2009 Jun 13.


Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes.

Ricardo E, Costa-de-Oliveira S, Dias AS, Guerra J, Rodrigues AG, Pina-Vaz C.

FEMS Yeast Res. 2009 Jun;9(4):618-25. doi: 10.1111/j.1567-1364.2009.00504.x. Epub 2009 Mar 30.


The genetic basis of fluconazole resistance development in Candida albicans.

Morschhäuser J.

Biochim Biophys Acta. 2002 Jul 18;1587(2-3):240-8. Review.

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