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Items: 1 to 20 of 636

1.

Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.

Mayer-Sonnenfeld T, Avrahami D, Friedman-Levi Y, Gabizon R.

Cell Mol Neurobiol. 2008 Nov;28(7):1005-15. doi: 10.1007/s10571-008-9274-1. Epub 2008 Mar 19.

PMID:
18350378
2.

The metabolism of glycosaminoglycans is impaired in prion diseases.

Mayer-Sonnenfeld T, Zeigler M, Halimi M, Dayan Y, Herzog C, Lasmezas CI, Gabizon R.

Neurobiol Dis. 2005 Dec;20(3):738-43. Epub 2005 Jun 13.

PMID:
15951190
3.

Dimethyl sulfoxide delays PrP sc accumulation and disease symptoms in prion-infected hamsters.

Shaked GM, Engelstein R, Avraham I, Kahana E, Gabizon R.

Brain Res. 2003 Sep 5;983(1-2):137-43.

PMID:
12914974
4.

Virus-induced alterations of membrane lipids affect the incorporation of PrP Sc into cells.

Avrahami D, Dayan-Amouyal Y, Tal S, Mincberg M, Davis C, Abramsky O, Gabizon R.

J Neurosci Res. 2008 Sep;86(12):2753-62. doi: 10.1002/jnr.21720.

PMID:
18478553
5.

PrPSc incorporation to cells requires endogenous glycosaminoglycan expression.

Hijazi N, Kariv-Inbal Z, Gasset M, Gabizon R.

J Biol Chem. 2005 Apr 29;280(17):17057-61. Epub 2005 Jan 24.

6.

Copaxone interferes with the PrP Sc-GAG interaction.

Engelstein R, Ovadia H, Gabizon R.

Eur J Neurol. 2007 Aug;14(8):877-84.

PMID:
17662008
7.

Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.

Wolf H, Graßmann A, Bester R, Hossinger A, Möhl C, Paulsen L, Groschup MH, Schätzl H, Vorberg I.

J Virol. 2015 Oct;89(19):9853-64. doi: 10.1128/JVI.01276-15. Epub 2015 Jul 22.

8.

The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

Ertmer A, Gilch S, Yun SW, Flechsig E, Klebl B, Stein-Gerlach M, Klein MA, Schätzl HM.

J Biol Chem. 2004 Oct 1;279(40):41918-27. Epub 2004 Jul 9.

9.

The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.

Yun SW, Ertmer A, Flechsig E, Gilch S, Riederer P, Gerlach M, Schätzl HM, Klein MA.

J Neurovirol. 2007 Aug;13(4):328-37.

PMID:
17849316
10.

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy.

Heiseke A, Aguib Y, Riemer C, Baier M, Schätzl HM.

J Neurochem. 2009 Apr;109(1):25-34. doi: 10.1111/j.1471-4159.2009.05906.x. Epub 2009 Feb 20.

11.

Monoclonal antibodies inhibit prion replication and delay the development of prion disease.

White AR, Enever P, Tayebi M, Mushens R, Linehan J, Brandner S, Anstee D, Collinge J, Hawke S.

Nature. 2003 Mar 6;422(6927):80-3.

PMID:
12621436
12.

Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.

Meier P, Genoud N, Prinz M, Maissen M, Rülicke T, Zurbriggen A, Raeber AJ, Aguzzi A.

Cell. 2003 Apr 4;113(1):49-60.

13.

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

Stewart RS, Piccardo P, Ghetti B, Harris DA.

J Neurosci. 2005 Mar 30;25(13):3469-77.

14.

Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin.

Haviv Y, Avrahami D, Ovadia H, Ben-Hur T, Gabizon R, Sharon R.

Arch Neurol. 2008 Jun;65(6):762-75. doi: 10.1001/archneur.65.6.762.

PMID:
18541796
15.

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease.

Korth C, May BC, Cohen FE, Prusiner SB.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9836-41.

16.

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF, Tatzelt J.

J Neurochem. 2008 Oct;107(1):218-29. doi: 10.1111/j.1471-4159.2008.05611.x. Epub 2008 Aug 7.

17.

Copper binding to PrPC may inhibit prion disease propagation.

Hijazi N, Shaked Y, Rosenmann H, Ben-Hur T, Gabizon R.

Brain Res. 2003 Dec 12;993(1-2):192-200.

PMID:
14642846
18.

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice.

Pfeifer A, Eigenbrod S, Al-Khadra S, Hofmann A, Mitteregger G, Moser M, Bertsch U, Kretzschmar H.

J Clin Invest. 2006 Dec;116(12):3204-10.

19.
20.

The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines.

Pimpinelli F, Lehmann S, Maridonneau-Parini I.

Eur J Neurosci. 2005 Apr;21(8):2063-72.

PMID:
15869502
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