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Results: 1 to 20 of 879

1.

Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.

Sapra P, Zhao H, Mehlig M, Malaby J, Kraft P, Longley C, Greenberger LM, Horak ID.

Clin Cancer Res. 2008 Mar 15;14(6):1888-96. doi: 10.1158/1078-0432.CCR-07-4456.

PMID:
18347192
[PubMed - indexed for MEDLINE]
Free Article
2.

Marked therapeutic efficacy of a novel polyethylene glycol-SN38 conjugate, EZN-2208, in xenograft models of B-cell non-Hodgkin's lymphoma.

Sapra P, Kraft P, Mehlig M, Malaby J, Zhao H, Greenberger LM, Horak ID.

Haematologica. 2009 Oct;94(10):1456-9. doi: 10.3324/haematol.2009.008276.

PMID:
19794091
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.

Allegrini G, Goulette FA, Darnowski JW, Calabresi P.

Cancer Chemother Pharmacol. 2004 Mar;53(3):261-6. Epub 2003 Dec 5.

PMID:
14658007
[PubMed - indexed for MEDLINE]
4.

Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice.

Lei S, Chien PY, Sheikh S, Zhang A, Ali S, Ahmad I.

Anticancer Drugs. 2004 Sep;15(8):773-8.

PMID:
15494639
[PubMed - indexed for MEDLINE]
5.

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects.

Sapra P, Kraft P, Pastorino F, Ribatti D, Dumble M, Mehlig M, Wang M, Ponzoni M, Greenberger LM, Horak ID.

Angiogenesis. 2011 Sep;14(3):245-53. doi: 10.1007/s10456-011-9209-1. Epub 2011 Mar 31.

PMID:
21452059
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers.

Zhao H, Rubio B, Sapra P, Wu D, Reddy P, Sai P, Martinez A, Gao Y, Lozanguiez Y, Longley C, Greenberger LM, Horak ID.

Bioconjug Chem. 2008 Apr;19(4):849-59. doi: 10.1021/bc700333s. Epub 2008 Mar 28.

PMID:
18370417
[PubMed - indexed for MEDLINE]
7.

Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts.

Prewett MC, Hooper AT, Bassi R, Ellis LM, Waksal HW, Hicklin DJ.

Clin Cancer Res. 2002 May;8(5):994-1003.

PMID:
12006511
[PubMed - indexed for MEDLINE]
Free Article
8.

Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.

Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, Ribatti D, Greenberger LM, Horak ID, Ponzoni M.

Clin Cancer Res. 2010 Oct 1;16(19):4809-21. doi: 10.1158/1078-0432.CCR-10-1354. Epub 2010 Aug 11.

PMID:
20702613
[PubMed - indexed for MEDLINE]
Free Article
9.

Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice.

Schluep T, Cheng J, Khin KT, Davis ME.

Cancer Chemother Pharmacol. 2006 May;57(5):654-62. Epub 2005 Aug 26.

PMID:
16133526
[PubMed - indexed for MEDLINE]
10.

Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.

Takiguchi S, Kumazawa E, Shimazoe T, Tohgo A, Kono A.

Jpn J Cancer Res. 1997 Aug;88(8):760-9. Erratum in: Jpn J Cancer Res 1997 Sep;88(9):919.

PMID:
9330608
[PubMed - indexed for MEDLINE]
11.

Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models.

Schluep T, Hwang J, Cheng J, Heidel JD, Bartlett DW, Hollister B, Davis ME.

Clin Cancer Res. 2006 Mar 1;12(5):1606-14.

PMID:
16533788
[PubMed - indexed for MEDLINE]
Free Article
12.

Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells.

Minko T, Paranjpe PV, Qiu B, Lalloo A, Won R, Stein S, Sinko PJ.

Cancer Chemother Pharmacol. 2002 Aug;50(2):143-50. Epub 2002 Jun 11.

PMID:
12172980
[PubMed - indexed for MEDLINE]
13.

P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.

Joshi KS, Rathos MJ, Mahajan P, Wagh V, Shenoy S, Bhatia D, Chile S, Sivakumar M, Maier A, Fiebig HH, Sharma S.

Mol Cancer Ther. 2007 Mar;6(3):926-34.

PMID:
17363487
[PubMed - indexed for MEDLINE]
Free Article
14.

Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.

Yu D, Peng P, Dharap SS, Wang Y, Mehlig M, Chandna P, Zhao H, Filpula D, Yang K, Borowski V, Borchard G, Zhang Z, Minko T.

J Control Release. 2005 Dec 10;110(1):90-102. Epub 2005 Nov 4.

PMID:
16271793
[PubMed - indexed for MEDLINE]
15.

Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.

Pratesi G, De Cesare M, Carenini N, Perego P, Righetti SC, Cucco C, Merlini L, Pisano C, Penco S, Carminati P, Vesci L, Zunino F.

Clin Cancer Res. 2002 Dec;8(12):3904-9.

PMID:
12473606
[PubMed - indexed for MEDLINE]
Free Article
16.

New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.

Van Hattum AH, Pinedo HM, Schlüper HM, Hausheer FH, Boven E.

Int J Cancer. 2000 Oct 15;88(2):260-6.

PMID:
11004678
[PubMed - indexed for MEDLINE]
17.

Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models.

Hoch U, Lynch J, Sato Y, Kashimoto S, Kajikawa F, Furutani Y, Silverman JA.

Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65. doi: 10.1007/s00280-008-0850-3. Epub 2008 Oct 19.

PMID:
18931998
[PubMed - indexed for MEDLINE]
18.

Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.

O'Reilly T, Wartmann M, Brueggen J, Allegrini PR, Floersheimer A, Maira M, McSheehy PM.

Cancer Chemother Pharmacol. 2008 Nov;62(6):1045-54. doi: 10.1007/s00280-008-0695-9. Epub 2008 Feb 27.

PMID:
18301895
[PubMed - indexed for MEDLINE]
19.

Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128).

Okuno S, Harada M, Yano T, Yano S, Kiuchi S, Tsuda N, Sakamura Y, Imai J, Kawaguchi T, Tsujihara K.

Cancer Res. 2000 Jun 1;60(11):2988-95.

PMID:
10850447
[PubMed - indexed for MEDLINE]
Free Article
20.

MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice.

Fujita F, Koike M, Fujita M, Sakamoto Y, Okuno S, Kawaguchi T, Yano S, Yano T, Kiuchi S, Fujiwara T, Kudoh S, Kakushima M.

Clin Cancer Res. 2005 Feb 15;11(4):1650-7.

PMID:
15746070
[PubMed - indexed for MEDLINE]
Free Article

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