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Results: 1 to 20 of 242

1.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Asano Y, Kitamura S, Ohra T, Itoh F, Kajino M, Tamura T, Kaneko M, Ikeda S, Igata H, Kawamoto T, Sogabe S, Matsumoto S, Tanaka T, Yamaguchi M, Kimura H, Fukumoto S.

Bioorg Med Chem. 2008 Apr 15;16(8):4699-714. doi: 10.1016/j.bmc.2008.02.028. Epub 2008 Feb 13.

PMID:
18313930
[PubMed - indexed for MEDLINE]
2.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Asano Y, Kitamura S, Ohra T, Aso K, Igata H, Tamura T, Kawamoto T, Tanaka T, Sogabe S, Matsumoto S, Yamaguchi M, Kimura H, Itoh F.

Bioorg Med Chem. 2008 Apr 15;16(8):4715-32. doi: 10.1016/j.bmc.2008.02.027. Epub 2008 Feb 13.

PMID:
18313304
[PubMed - indexed for MEDLINE]
3.

Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity.

Stocks MJ, Barber S, Ford R, Leroux F, St-Gallay S, Teague S, Xue Y.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3459-62.

PMID:
15950471
[PubMed - indexed for MEDLINE]
4.

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2.

PMID:
17107797
[PubMed - indexed for MEDLINE]
5.

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.

Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.

Bioorg Med Chem Lett. 2006 May 15;16(10):2590-4. Epub 2006 Mar 9.

PMID:
16527482
[PubMed - indexed for MEDLINE]
6.

Structural requirements of isoquinolones as novel selective c-Jun N-terminal kinase 1 inhibitors: 2D and 3D QSAR analyses.

Du J, Xi L, Lei B, Liu H, Yao X.

Chem Biol Drug Des. 2011 Apr;77(4):248-54. doi: 10.1111/j.1747-0285.2010.01068.x. Epub 2011 Jan 28.

PMID:
21276204
[PubMed - indexed for MEDLINE]
7.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G.

J Med Chem. 2006 Jul 27;49(15):4455-8.

PMID:
16854050
[PubMed - indexed for MEDLINE]
8.

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Alam M, Beevers RE, Ceska T, Davenport RJ, Dickson KM, Fortunato M, Gowers L, Haughan AF, James LA, Jones MW, Kinsella N, Lowe C, Meissner JW, Nicolas AL, Perry BG, Phillips DJ, Pitt WR, Platt A, Ratcliffe AJ, Sharpe A, Tait LJ.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3463-7. Epub 2007 Mar 30.

PMID:
17459703
[PubMed - indexed for MEDLINE]
9.

Discovery of a novel series of 4-quinolone JNK inhibitors.

Gong L, Tan YC, Boice G, Abbot S, McCaleb K, Iyer P, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Lukacs CM, Ursula Kammlott R, Kuglstatter A, Goldstein D.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7381-7. doi: 10.1016/j.bmcl.2012.10.066. Epub 2012 Oct 24.

PMID:
23142618
[PubMed - indexed for MEDLINE]
10.

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

Gaillard P, Jeanclaude-Etter I, Ardissone V, Arkinstall S, Cambet Y, Camps M, Chabert C, Church D, Cirillo R, Gretener D, Halazy S, Nichols A, Szyndralewiez C, Vitte PA, Gotteland JP.

J Med Chem. 2005 Jul 14;48(14):4596-607.

PMID:
15999997
[PubMed - indexed for MEDLINE]
11.

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.

Van HT, Le QM, Lee KY, Lee ES, Kwon Y, Kim TS, Le TN, Lee SH, Cho WJ.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5763-7. Epub 2007 Aug 29.

PMID:
17827007
[PubMed - indexed for MEDLINE]
12.

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Grunewald GL, Seim MR, Regier RC, Martin JL, Gee CL, Drinkwater N, Criscione KR.

J Med Chem. 2006 Sep 7;49(18):5424-33.

PMID:
16942016
[PubMed - indexed for MEDLINE]
13.

Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase.

Cockcroft XL, Dillon KJ, Dixon L, Drzewiecki J, Kerrigan F, Loh VM Jr, Martin NM, Menear KA, Smith GC.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):1040-4. Epub 2005 Nov 15.

PMID:
16290932
[PubMed - indexed for MEDLINE]
14.

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.

Wang X, Sarris K, Kage K, Zhang D, Brown SP, Kolasa T, Surowy C, El Kouhen OF, Muchmore SW, Brioni JD, Stewart AO.

J Med Chem. 2009 Jan 8;52(1):170-80. doi: 10.1021/jm801042a.

PMID:
19072118
[PubMed - indexed for MEDLINE]
15.

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

Jiang R, Duckett D, Chen W, Habel J, Ling YY, LoGrasso P, Kamenecka TM.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6378-82. Epub 2007 Aug 26.

PMID:
17911023
[PubMed - indexed for MEDLINE]
16.

Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase.

Miki T, Kori M, Fujishima A, Mabuchi H, Tozawa Ri, Nakamura M, Sugiyama Y, Yukimasa H.

Bioorg Med Chem. 2002 Feb;10(2):385-400.

PMID:
11741787
[PubMed - indexed for MEDLINE]
17.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP.

J Med Chem. 2008 Oct 23;51(20):6259-62. doi: 10.1021/jm800914n. Epub 2008 Sep 24.

PMID:
18811140
[PubMed - indexed for MEDLINE]
18.

Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.

Lippa B, Morris J, Corbett M, Kwan TA, Noe MC, Snow SL, Gant TG, Mangiaracina M, Coffey HA, Foster B, Knauth EA, Wessel MD.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3444-8. Epub 2006 Apr 24.

PMID:
16632359
[PubMed - indexed for MEDLINE]
19.

Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors.

GarcĂ­a MD, Wilson AJ, Emmerson DP, Jenkins PR, Mahale S, Chaudhuri B.

Org Biomol Chem. 2006 Dec 21;4(24):4478-84. Epub 2006 Nov 9.

PMID:
17268643
[PubMed - indexed for MEDLINE]
20.

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, Ragazzon PA, Garbett NC, Chaires JB, Hollingshead M, Cushman M.

J Med Chem. 2006 Aug 24;49(17):5129-40.

PMID:
16913702
[PubMed - indexed for MEDLINE]

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