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Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection.

Kuerten S, Nowacki TM, Kleen TO, Asaad RJ, Lehmann PV, Tary-Lehmann M.

AIDS Res Hum Retroviruses. 2008 Jan;24(1):62-71. doi: 10.1089/aid.2007.0125.


Tc1 effector diversity shows dissociated expression of granzyme B and interferon-gamma in HIV infection.

Kleen TO, Asaad R, Landry SJ, Boehm BO, Tary-Lehmann M.

AIDS. 2004 Feb 20;18(3):383-92.


Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.

Nowacki TM, Kuerten S, Zhang W, Shive CL, Kreher CR, Boehm BO, Lehmann PV, Tary-Lehmann M.

Cell Immunol. 2007 May;247(1):36-48. Epub 2007 Sep 7.


Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease.

Bronke C, Palmer NM, Jansen CA, Westerlaken GH, Polstra AM, Reiss P, Bakker M, Miedema F, Tesselaar K, van Baarle D.

J Infect Dis. 2005 Mar 15;191(6):873-80. Epub 2005 Jan 31.


Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.

Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G.

J Immunol. 2005 Mar 1;174(5):2900-9.


Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection.

Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF.

J Immunol. 2004 Jul 1;173(1):641-8.


The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CD8 effector-memory T lymphocytes in HIV-infected patients.

Combadière B, Faure S, Autran B, Debré P, Combadière C.

AIDS. 2003 Jun 13;17(9):1279-90.


Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

Johnson BJ, Costelloe EO, Fitzpatrick DR, Haanen JB, Schumacher TN, Brown LE, Kelso A.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2657-62. Epub 2003 Feb 24.


Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function.

Ince MN, Harnisch B, Xu Z, Lee SK, Lange C, Moretta L, Lederman M, Lieberman J.

Immunology. 2004 Aug;112(4):531-42.


HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.

Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M.

Blood. 2004 Jul 15;104(2):487-94. Epub 2004 Apr 1.


Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.

Andersson J, Behbahani H, Lieberman J, Connick E, Landay A, Patterson B, Sönnerborg A, Loré K, Uccini S, Fehniger TE.

AIDS. 1999 Jul 30;13(11):1295-303.


A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals.

Larsson M, Jin X, Ramratnam B, Ogg GS, Engelmayer J, Demoitie MA, McMichael AJ, Cox WI, Steinman RM, Nixon D, Bhardwaj N.

AIDS. 1999 May 7;13(7):767-77.


CD8 T cell effector maturation in HIV-1-infected children.

Jordan KA, Furlan SN, Gonzalez VD, Karlsson AC, Quigley MF, Deeks SG, Rosenberg MG, Nixon DF, Sandberg JK.

Virology. 2006 Mar 30;347(1):117-26. Epub 2006 Jan 6.


[Immunodominance in CD8+ T cell responses to HIV-1 synthesized epitopes].

Tang YB, Tang XP, Jin X.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Sep;21(3):217-9. Chinese.


A systematic comparison of methods to measure HIV-1 specific CD8 T cells.

Sun Y, Iglesias E, Samri A, Kamkamidze G, Decoville T, Carcelain G, Autran B.

J Immunol Methods. 2003 Jan 15;272(1-2):23-34.


Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals.

Trabattoni D, Piconi S, Biasin M, Rizzardini G, Migliorino M, Seminari E, Boasso A, Piacentini L, Villa ML, Maserati R, Clerici M.

AIDS. 2004 Apr 9;18(6):859-69.


Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J.

Blood. 2003 Jan 1;101(1):226-35. Epub 2002 Aug 22.

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