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Results: 1 to 20 of 195

1.

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

Radichev I, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Gen Virol. 2008 Mar;89(Pt 3):636-41. doi: 10.1099/vir.0.83359-0.

PMID:
18272753
[PubMed - indexed for MEDLINE]
Free Article
2.

Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viral replication.

Jia F, Fan J, Zhang B, Yuan Z.

Virol Sin. 2013 Feb;28(1):16-23. doi: 10.1007/s12250-013-3276-y. Epub 2013 Jan 16.

PMID:
23325418
[PubMed - indexed for MEDLINE]
3.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U.

Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12.

PMID:
16532006
[PubMed - indexed for MEDLINE]
4.
5.

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.

Johnston PA, Phillips J, Shun TY, Shinde S, Lazo JS, Huryn DM, Myers MC, Ratnikov BI, Smith JW, Su Y, Dahl R, Cosford ND, Shiryaev SA, Strongin AY.

Assay Drug Dev Technol. 2007 Dec;5(6):737-50. doi: 10.1089/adt.2007.101.

PMID:
18181690
[PubMed - indexed for MEDLINE]
6.

Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY.

J Virol. 2007 May;81(9):4501-9. Epub 2007 Feb 14.

PMID:
17301157
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

Protein Expr Purif. 2007 Apr;52(2):334-9. Epub 2006 Dec 1.

PMID:
17189703
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR.

J Biol Chem. 2006 Dec 15;281(50):38448-58. Epub 2006 Oct 19.

PMID:
17052977
[PubMed - indexed for MEDLINE]
Free Article
9.

West Nile Virus NS2B/NS3 protease as an antiviral target.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR.

Curr Med Chem. 2008;15(27):2771-84. Review.

PMID:
18991636
[PubMed - indexed for MEDLINE]
10.

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR.

J Gen Virol. 2008 Apr;89(Pt 4):1010-4. doi: 10.1099/vir.0.83447-0.

PMID:
18343843
[PubMed - indexed for MEDLINE]
Free Article
11.

Characterization of the West Nile virus protease substrate specificity and inhibitors.

Mueller NH, Yon C, Ganesh VK, Padmanabhan R.

Int J Biochem Cell Biol. 2007;39(3):606-14. Epub 2006 Nov 23.

PMID:
17188926
[PubMed - indexed for MEDLINE]
12.

Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease.

Lin CW, Huang HD, Shiu SY, Chen WJ, Tsai MH, Huang SH, Wan L, Lin YJ.

Virus Res. 2007 Jul;127(1):88-94. Epub 2007 Apr 30.

PMID:
17467838
[PubMed - indexed for MEDLINE]
13.

Homology modeling and molecular dynamics simulations of Dengue virus NS2B/NS3 protease: insight into molecular interaction.

Wichapong K, Pianwanit S, Sippl W, Kokpol S.

J Mol Recognit. 2010 May-Jun;23(3):283-300. doi: 10.1002/jmr.977.

PMID:
19693793
[PubMed - indexed for MEDLINE]
14.

Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.

Shiryaev SA, Cheltsov AV, Gawlik K, Ratnikov BI, Strongin AY.

Assay Drug Dev Technol. 2011 Feb;9(1):69-78. doi: 10.1089/adt.2010.0309. Epub 2010 Nov 4.

PMID:
21050032
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.

Chernov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Biol Chem. 2008 Jun 20;283(25):17270-8. doi: 10.1074/jbc.M801719200. Epub 2008 Apr 28.

PMID:
18442976
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Chappell KJ, Nall TA, Stoermer MJ, Fang NX, Tyndall JD, Fairlie DP, Young PR.

J Biol Chem. 2005 Jan 28;280(4):2896-903. Epub 2004 Oct 19.

PMID:
15494419
[PubMed - indexed for MEDLINE]
Free Article
17.

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease.

Nall TA, Chappell KJ, Stoermer MJ, Fang NX, Tyndall JD, Young PR, Fairlie DP.

J Biol Chem. 2004 Nov 19;279(47):48535-42. Epub 2004 Aug 18.

PMID:
15322074
[PubMed - indexed for MEDLINE]
Free Article
18.

Mechanism of NS2B-mediated activation of NS3pro in dengue virus: molecular dynamics simulations and bioassays.

Zuo Z, Liew OW, Chen G, Chong PC, Lee SH, Chen K, Jiang H, Puah CM, Zhu W.

J Virol. 2009 Jan;83(2):1060-70. doi: 10.1128/JVI.01325-08. Epub 2008 Oct 29.

PMID:
18971276
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Activation of the West Nile virus NS3 protease: molecular dynamics evidence for a conformational selection mechanism.

Ekonomiuk D, Caflisch A.

Protein Sci. 2009 May;18(5):1003-11. doi: 10.1002/pro.110.

PMID:
19388022
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities.

Chambers TJ, Droll DA, Tang Y, Liang Y, Ganesh VK, Murthy KH, Nickells M.

J Gen Virol. 2005 May;86(Pt 5):1403-13.

PMID:
15831952
[PubMed - indexed for MEDLINE]
Free Article

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