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Results: 1 to 20 of 102

1.

Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.

Liu J, Lu W, Reigada D, Nguyen J, Laties AM, Mitchell CH.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):772-80. doi: 10.1167/iovs.07-0675.

PMID:
18235027
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells.

Guha S, Liu J, Baltazar G, Laties AM, Mitchell CH.

Adv Exp Med Biol. 2014;801:105-11. doi: 10.1007/978-1-4614-3209-8_14. Review.

PMID:
24664687
[PubMed - indexed for MEDLINE]
3.

Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.

Guha S, Baltazar GC, Tu LA, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH.

J Neurochem. 2012 Aug;122(4):823-33. doi: 10.1111/j.1471-4159.2012.07804.x. Epub 2012 Jun 27.

PMID:
22639870
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.

Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH.

Am J Physiol Cell Physiol. 2012 Jul 15;303(2):C160-9. doi: 10.1152/ajpcell.00278.2011. Epub 2012 May 9.

PMID:
22572847
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

Holz FG, Schütt F, Kopitz J, Eldred GE, Kruse FE, Völcker HE, Cantz M.

Invest Ophthalmol Vis Sci. 1999 Mar;40(3):737-43.

PMID:
10067978
[PubMed - indexed for MEDLINE]
Free Article
6.

Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.

Guha S, Baltazar GC, Coffey EE, Tu LA, Lim JC, Beckel JM, Patel S, Eysteinsson T, Lu W, O'Brien-Jenkins A, Laties AM, Mitchell CH.

FASEB J. 2013 Nov;27(11):4500-9. doi: 10.1096/fj.13-236166. Epub 2013 Aug 20.

PMID:
23964074
[PubMed - indexed for MEDLINE]
7.

Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

Baltazar GC, Guha S, Lu W, Lim J, Boesze-Battaglia K, Laties AM, Tyagi P, Kompella UB, Mitchell CH.

PLoS One. 2012;7(12):e49635. doi: 10.1371/journal.pone.0049635. Epub 2012 Dec 18.

PMID:
23272048
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

[Mechanism of the inhibition of lysosomal functions in the retinal pigment epithelium by lipofuscin retinoid component A2-E].

Schütt F, Bergmann M, Kopitz J, Holz FG.

Ophthalmologe. 2001 Aug;98(8):721-4. German.

PMID:
11552410
[PubMed - indexed for MEDLINE]
9.

Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration.

Bergmann M, Schütt F, Holz FG, Kopitz J.

FASEB J. 2004 Mar;18(3):562-4. Epub 2004 Jan 8.

PMID:
14715704
[PubMed - indexed for MEDLINE]
Free Article
10.

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.

Finnemann SC, Leung LW, Rodriguez-Boulan E.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3842-7.

PMID:
11904436
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy.

Mahon GJ, Anderson HR, Gardiner TA, McFarlane S, Archer DB, Stitt AW.

Curr Eye Res. 2004 Apr;28(4):277-84.

PMID:
15259297
[PubMed - indexed for MEDLINE]
12.

Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells.

Sundelin SP, Terman A.

APMIS. 2002 Jun;110(6):481-9.

PMID:
12193209
[PubMed - indexed for MEDLINE]
13.

[N-acetylcysteine improves lysosomal function and enhances the degradation of photoreceptor outer segments in cultured RPE cells].

Schütt F, Völcker HE, Dithmar S.

Klin Monbl Augenheilkd. 2007 Jul;224(7):580-4. German.

PMID:
17657692
[PubMed - indexed for MEDLINE]
14.

Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration.

Radu RA, Hu J, Yuan Q, Welch DL, Makshanoff J, Lloyd M, McMullen S, Travis GH, Bok D.

J Biol Chem. 2011 May 27;286(21):18593-601. doi: 10.1074/jbc.M110.191866. Epub 2011 Apr 4.

PMID:
21464132
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal.

Boyer NP, Higbee D, Currin MB, Blakeley LR, Chen C, Ablonczy Z, Crouch RK, Koutalos Y.

J Biol Chem. 2012 Jun 22;287(26):22276-86. doi: 10.1074/jbc.M111.329235. Epub 2012 May 8.

PMID:
22570475
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.

Schütt F, Davies S, Kopitz J, Holz FG, Boulton ME.

Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2303-8.

PMID:
10892877
[PubMed - indexed for MEDLINE]
Free Article
17.

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.

Maeda A, Golczak M, Maeda T, Palczewski K.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5435-43. doi: 10.1167/iovs.09-3944. Epub 2009 Jun 24.

PMID:
19553623
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Melanin granules of retinal pigment epithelium are connected with the lysosomal degradation pathway.

Schraermeyer U, Peters S, Thumann G, Kociok N, Heimann K.

Exp Eye Res. 1999 Feb;68(2):237-45.

PMID:
10068489
[PubMed - indexed for MEDLINE]
19.

Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations.

Guha S, Coffey EE, Lu W, Lim JC, Beckel JM, Laties AM, Boesze-Battaglia K, Mitchell CH.

Exp Eye Res. 2014 Sep;126:68-76. doi: 10.1016/j.exer.2014.05.013.

PMID:
25152362
[PubMed - in process]
20.

Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.

Poliakov E, Strunnikova NV, Jiang JK, Martinez B, Parikh T, Lakkaraju A, Thomas C, Brooks BP, Redmond TM.

Mol Vis. 2014 Mar 14;20:285-300. eCollection 2014.

PMID:
24644403
[PubMed - in process]
Free PMC Article

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