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18222959,16411023,22004361,19151258,10571551,17941891,23336403,7553727,15178564,17220176,17157294,18789320,18455926,15567190,18083782,22977010,24473199,20125034,17896117,10652188,19286954,28183205,12883834,21083698,16901477,20127248,17339545,18505453,18484962,16010601,23106693,14691041,21093430,17940706,30597772,15381965,15676056,18165545,12606259,22266969,22789658,15292457,26763290,24178833,23929248,22954178,15327994,23463182,17468933,19286961,22411971,18516352,23525447,19207715,18931029,22809038,22542438,15308554,12816694,22166638,26846272,18390819,22075552,21666107,26519026,20421349,21827639,27378570,20852051,22659627,11914261,21282198,19617412,17268885,29414428,19298538,27028009,19809279,23595215,23680771,19380418,27246989,21679220,25672441,22715398,29856969,21875500,18267957,8866884,26597117,22466958,11309257,20379769,23747931,7543634,15242972,28556946,27057277,26674286,14693683,25849791,29910216,15148246,16787577,27171264,9057081,28118517,10690341,26058828,20435846,19969468,28073832,23848060,25589055,22635074,17620005,22179023,22029532,28977786,23846413,25231456,18223294,19726439,15210584,29409011,16155579,15142844,25870184,22881281,30729348,8564215,26044583,24084854,23262803,10851213,18931027,24041262,17395631,16435070,11399252,20877127,25595132,14557259,26449403,15475833,28276718,19213760,19616003,17658509,21422102,22344601,14990356,25345742,19666677,23665492,30992077,26598930,23851919,19027847,26792585,21621617,31853618,22436846,22397940,12969888,18855521,20543091,22704546,24105420,20450569,11179053,25253080,12944390,28219936,29045568,7698143,24297260,26541785,18068196,22968213,25272944,31377586,17606840,17526656,16955284,15870202,17341689,18390563,23922853,22585618,24815143,17308009,11739285,20097771,23067403,28150462,17873104,21828282,15358610,18359895,17906103,29582211,26489513,10482921,26387613,12107173,26186740,21153603,27960187,17496214,18001768,11325804,25178948,18622247,28178430,23419451,19656779,18235500,23507724,9415273,22013385,21803944,30002490,22126194,21912612,10807653,26058040,21151615,30681368,21915473,23666677,22484620,20351564,16286350,19388003,16542646,31217391,16382295,27809355,11584267,22622706,22385356,15883754,21908789,22230897,17225566,22328772,18689499,11223426,16847434,19717735,24259501,29940198,24694647,26667494,25672911,17081080,23044225,27129181,11470468,26450997,23417421,7760362,17664136,23455198,11499751,9475539,20693395,22882904,23669719,19287816,18327703,28119233,32567476,24768874,32103377,25757463,12575984,20953685,10826919,24220799,25688987,22571393,23766850,12623790,26167913,17924178,28744974,16418318,23291914,25888509,25205781,12813004,17006071,15159281,24324809,11354240,24682353,22860052,17577097,30526144,30074840,21836066,28906548,30165375,21402077,24868147,25126708,28848091,27381758,17075027,22553001,24845581,17157283,24271017,30496354,22869254,24595307,9622144,18425301,15220775,24685640,22851653,30717560,10510452,22792740,30204367,19213952,18691357,22913659,28763627,20229055,21693368,18555028,22635076,29487197,18469150,21671887,18946174,15604043,30881990,18192224,15639473,15010280,21680754,30624512,30653603,14609750,9714095,28259938,21880866,28453728,20525875,26607864,9323086,14732742,11684075,11179278,25400168,26476037,12381417,15883753,26364514,26849825,21091073,9861311,10465353,10025949,12843684,23889688,25889299,15347817,17537411,18408136,24651518,20705694,21795433,20167841,18703049,12775977,29931049,20640495,24312696,18665799,17541736,24127984,18006459,24286628,11514319,25147200,11589521,26192027,25684185,17270171,19597369,9315556,28444132,27930802,31030549,25924621,16645453,23086649,22467307,21307089,33825404,15725950,22316165,27966000,24471974,17287464,22994795,30797815,31776590,29476764,16428343,27780890,16715121,19202319,17470570,26146654,23179953,22652602,19038864,22542793,23788572,30929154,25156855,32788926,9932719,26966340,23484128,23266283,30308197,28906529,11154795,10766409,17049285,24166314,10217657,18617528,25502809,17126307,28421341,23600393,30621358,23497275,27694220,27831744,29655978,11432452,10406819,36112326,23201226,34830353,16132725,20028693,22564802,11457753,27456523,9435634,22152956,23065382,20694792,19704099,26191152,26098549,19346460,20955429,26696240,17188708,22775214,18693249,23841996,30637549,22902709,18660450,29375110,22514273,19997057,15792991,12598407,18182064,26304700,24928309,19096023,17114245,24431217,21169294,11770004,10975600,28736260,23264539,23610574,29016740,11834008,24465805,11478786,27015742,7971169,24839185,21178298,24067598,27109157,18936329,29895586,27296507,22228849,22496404,8613621,25806690,17127814,33483761,17615684,26884059,19162037,33611830,22030894,26045476,30715251,26661577,15718263,7582482,12048075,25959758,21378145,21925349,29274332,23165766,33640872,22140481,25870106,20579545,32351005,21890689,17890433,7579837,11531651,28551880,28238218,22159320,23762381,9835314,15314686,29018142,32215448,10912452,27217295,34400167,19299645,27866931,10903999,23129587,18006466,24923878,11964374,12667952,26363472,21207704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Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide.

Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjöquist PO, Pernow J. Gonon AT, et al. Cardiovasc Res. 2008 Apr 1;78(1):116-22. doi: 10.1093/cvr/cvn017. Epub 2008 Jan 25. Cardiovasc Res. 2008. PMID: 18222959

Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.

Bulhak AA, Sjöquist PO, Xu CB, Edvinsson L, Pernow J. Bulhak AA, et al. Basic Res Cardiol. 2006 May;101(3):244-52. doi: 10.1007/s00395-005-0580-1. Epub 2006 Jan 20. Basic Res Cardiol. 2006. PMID: 16411023

Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.

Lv L, Jiang SS, Xu J, Gong JB, Cheng Y. Lv L, et al. Clin Exp Pharmacol Physiol. 2012 Jan;39(1):20-7. doi: 10.1111/j.1440-1681.2011.05628.x. Clin Exp Pharmacol Physiol. 2012. PMID: 22004361

PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.

Bulhak AA, Jung C, Ostenson CG, Lundberg JO, Sjöquist PO, Pernow J. Bulhak AA, et al. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H719-27. doi: 10.1152/ajpheart.00394.2008. Epub 2009 Jan 16. Am J Physiol Heart Circ Physiol. 2009. PMID: 19151258 Free article.

The role of the L-arginine/nitric oxide pathway in myocardial ischaemic and reperfusion injury.

Pernow J, Wang QD. Pernow J, et al. Acta Physiol Scand. 1999 Oct;167(2):151-9. doi: 10.1046/j.1365-201x.1999.00588.x. Acta Physiol Scand. 1999. PMID: 10571551

Evidence that hydroxysafflor yellow A protects the heart against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Liu YN, Zhou ZM, Chen P. Liu YN, et al. Clin Exp Pharmacol Physiol. 2008 Feb;35(2):211-6. doi: 10.1111/j.1440-1681.2007.04814.x. Epub 2007 Oct 17. Clin Exp Pharmacol Physiol. 2008. PMID: 17941891

Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult.

Huang C, Cui Y, Ji L, Zhang W, Li R, Ma L, Xing W, Zhou H, Chen B, Yu J, Zhang H. Huang C, et al. Pharm Biol. 2013 Apr;51(4):463-73. doi: 10.3109/13880209.2012.740052. Epub 2013 Jan 22. Pharm Biol. 2013. PMID: 23336403

Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit.

Williams MW, Taft CS, Ramnauth S, Zhao ZQ, Vinten-Johansen J. Williams MW, et al. Cardiovasc Res. 1995 Jul;30(1):79-86. Cardiovasc Res. 1995. PMID: 7553727

Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation.

Kupatt C, Dessy C, Hinkel R, Raake P, Daneau G, Bouzin C, Boekstegers P, Feron O. Kupatt C, et al. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1435-41. doi: 10.1161/01.ATV.0000134300.87476.d1. Epub 2004 Jun 3. Arterioscler Thromb Vasc Biol. 2004. PMID: 15178564

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

Hamid SA, Bower HS, Baxter GF. Hamid SA, et al. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2598-606. doi: 10.1152/ajpheart.01393.2006. Epub 2007 Jan 12. Am J Physiol Heart Circ Physiol. 2007. PMID: 17220176 Free article.

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