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Results: 1 to 20 of 331

1.

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.

Petković H, Sandmann A, Challis IR, Hecht HJ, Silakowski B, Low L, Beeston N, Kuscer E, Garcia-Bernardo J, Leadlay PF, Kendrew SG, Wilkinson B, Müller R.

Org Biomol Chem. 2008 Feb 7;6(3):500-6. doi: 10.1039/b714804f. Epub 2007 Dec 12.

PMID:
18219420
[PubMed - indexed for MEDLINE]
2.

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.

Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C.

Biochemistry. 2004 Nov 9;43(44):13892-8.

PMID:
15518537
[PubMed - indexed for MEDLINE]
3.

Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum.

Wilkinson CJ, Frost EJ, Staunton J, Leadlay PF.

Chem Biol. 2001 Dec;8(12):1197-208.

PMID:
11755398
[PubMed - indexed for MEDLINE]
Free Article
4.

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.

Lau J, Fu H, Cane DE, Khosla C.

Biochemistry. 1999 Feb 2;38(5):1643-51.

PMID:
9931032
[PubMed - indexed for MEDLINE]
5.

Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei.

Tang L, Yoon YJ, Choi CY, Hutchinson CR.

Gene. 1998 Aug 31;216(2):255-65.

PMID:
9729415
[PubMed - indexed for MEDLINE]
6.

Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase.

Jiralerspong S, Rangaswamy V, Bender CL, Parry RJ.

Gene. 2001 May 30;270(1-2):191-200.

PMID:
11404016
[PubMed - indexed for MEDLINE]
7.

Mechanisms of molecular recognition in the pikromycin polyketide synthase.

Chen S, Xue Y, Sherman DH, Reynolds KA.

Chem Biol. 2000 Dec;7(12):907-18.

PMID:
11137814
[PubMed - indexed for MEDLINE]
Free Article
8.

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.

Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C.

J Am Chem Soc. 2003 May 7;125(18):5366-74.

PMID:
12720450
[PubMed - indexed for MEDLINE]
9.

A polylinker approach to reductive loop swaps in modular polyketide synthases.

Kellenberger L, Galloway IS, Sauter G, Böhm G, Hanefeld U, Cortés J, Staunton J, Leadlay PF.

Chembiochem. 2008 Nov 3;9(16):2740-9. doi: 10.1002/cbic.200800332.

PMID:
18937219
[PubMed - indexed for MEDLINE]
10.

Active-site residue, domain and module swaps in modular polyketide synthases.

Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF.

J Ind Microbiol Biotechnol. 2003 Aug;30(8):489-94. Epub 2003 Jun 14.

PMID:
12811585
[PubMed - indexed for MEDLINE]
11.

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

Reeves CD, Murli S, Ashley GW, Piagentini M, Hutchinson CR, McDaniel R.

Biochemistry. 2001 Dec 25;40(51):15464-70.

PMID:
11747421
[PubMed - indexed for MEDLINE]
12.

Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.

Liou GF, Lau J, Cane DE, Khosla C.

Biochemistry. 2003 Jan 14;42(1):200-7.

PMID:
12515555
[PubMed - indexed for MEDLINE]
13.

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.

Kwan DH, Leadlay PF.

ACS Chem Biol. 2010 Sep 17;5(9):829-38. doi: 10.1021/cb100175a.

PMID:
20666435
[PubMed - indexed for MEDLINE]
14.

Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF.

FEBS J. 2005 May;272(10):2373-87.

PMID:
15885088
[PubMed - indexed for MEDLINE]
Free Article
15.

Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB.

Hughes AJ, Keatinge-Clay A.

Chem Biol. 2011 Feb 25;18(2):165-76. doi: 10.1016/j.chembiol.2010.12.014.

PMID:
21338915
[PubMed - indexed for MEDLINE]
Free Article
16.

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

Ruan X, Pereda A, Stassi DL, Zeidner D, Summers RG, Jackson M, Shivakumar A, Kakavas S, Staver MJ, Donadio S, Katz L.

J Bacteriol. 1997 Oct;179(20):6416-25.

PMID:
9335291
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity.

Kelly WL, Hillson NJ, Walsh CT.

Biochemistry. 2005 Oct 11;44(40):13385-93.

PMID:
16201763
[PubMed - indexed for MEDLINE]
18.

Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases.

Yadav G, Gokhale RS, Mohanty D.

J Mol Biol. 2003 Apr 25;328(2):335-63.

PMID:
12691745
[PubMed - indexed for MEDLINE]
19.

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases.

Haydock SF, Aparicio JF, Molnár I, Schwecke T, Khaw LE, König A, Marsden AF, Galloway IS, Staunton J, Leadlay PF.

FEBS Lett. 1995 Oct 30;374(2):246-8.

PMID:
7589545
[PubMed - indexed for MEDLINE]
Free Article
20.

Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.

Murli S, Piagentini M, McDaniel R, Hutchinson CR.

Biochemistry. 2004 Dec 21;43(50):15884-90.

PMID:
15595843
[PubMed - indexed for MEDLINE]

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