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Items: 1 to 20 of 358

1.

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

Lu IL, Tsai KC, Chiang YK, Jiaang WT, Wu SH, Mahindroo N, Chien CH, Lee SJ, Chen X, Chao YS, Wu SY.

Eur J Med Chem. 2008 Aug;43(8):1603-11. doi: 10.1016/j.ejmech.2007.11.014. Epub 2007 Nov 29. Erratum in: Eur J Med Chem. 2009 Jun;44(6):2763.

PMID:
18207285
2.

Discovery of DPP IV inhibitors by pharmacophore modeling and QSAR analysis followed by in silico screening.

Al-Masri IM, Mohammad MK, Taha MO.

ChemMedChem. 2008 Nov;3(11):1763-79. doi: 10.1002/cmdc.200800213.

PMID:
18989859
3.

Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine.

Al-masri IM, Mohammad MK, Tahaa MO.

J Enzyme Inhib Med Chem. 2009 Oct;24(5):1061-6. doi: 10.1080/14756360802610761.

PMID:
19640223
4.

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA, Lubben TH, Yong H, Pireh D, Pei Z, Basha F, Wiedeman PE, von Geldern TW, Trevillyan JM, Stoll VS.

Biochemistry. 2006 Jun 20;45(24):7474-82.

PMID:
16768443
5.

Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.

Wang L, Zhang B, Ji J, Li B, Yan J, Zhang W, Wu Y, Wang X.

Eur J Med Chem. 2009 Aug;44(8):3318-22. doi: 10.1016/j.ejmech.2009.03.021. Epub 2009 Mar 26.

PMID:
19375196
6.
7.
8.

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Huang CH, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang YW, Wu SH, Wang MH, Chen X, Chao YS, Jiaang WT.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1908-12. doi: 10.1016/j.bmcl.2009.02.061. Epub 2009 Feb 21.

PMID:
19269819
9.

(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Nitta A, Fujii H, Sakami S, Nishimura Y, Ohyama T, Satoh M, Nakaki J, Satoh S, Inada C, Kozono H, Kumagai H, Shimamura M, Fukazawa T, Kawai H.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5435-8. doi: 10.1016/j.bmcl.2008.09.042. Epub 2008 Sep 12.

PMID:
18819797
10.

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice.

Kim SJ, Nian C, Doudet DJ, McIntosh CH.

Diabetes. 2008 May;57(5):1331-9. doi: 10.2337/db07-1639. Epub 2008 Feb 25.

11.

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.

McKillop AM, Duffy NA, Lindsay JR, Green BD, Patterson S, O'Harte FP, Bell PM, Flatt PR.

Eur J Endocrinol. 2009 Dec;161(6):877-85. doi: 10.1530/EJE-09-0547. Epub 2009 Sep 15.

12.

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays.

Guasch L, Ojeda MJ, González-Abuín N, Sala E, Cereto-Massagué A, Mulero M, Valls C, Pinent M, Ardévol A, Garcia-Vallvé S, Pujadas G.

PLoS One. 2012;7(9):e44971. doi: 10.1371/journal.pone.0044971. Epub 2012 Sep 12.

13.

Molecular recognition of ligands in dipeptidyl peptidase IV.

Kuhn B, Hennig M, Mattei P.

Curr Top Med Chem. 2007;7(6):609-19. Review.

PMID:
17352681
14.

Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery.

Van der Veken P, Haemers A, Augustyns K.

Curr Top Med Chem. 2007;7(6):621-35. Review.

PMID:
17352682
15.

Dipeptidyl-peptidase IV-beta--further characterization and comparison to dipeptidyl-peptidase IV activity of CD26.

Blanco J, Nguyen C, Callebaut C, Jacotot E, Krust B, Mazaleyrat JP, Wakselman M, Hovanessian AG.

Eur J Biochem. 1998 Sep 1;256(2):369-78.

16.

Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.

Wu D, Jin F, Lu W, Zhu J, Li C, Wang W, Tang Y, Jiang H, Huang J, Liu G, Li J.

Chem Biol Drug Des. 2012 Jun;79(6):897-906. doi: 10.1111/j.1747-0285.2012.01365.x. Epub 2012 Mar 21.

PMID:
22381062
17.

Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor.

Gupta RC, Chhipa L, Mandhare AB, Zambad SP, Chauthaiwale V, Nadkarni SS, Dutt C.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5021-5. doi: 10.1016/j.bmcl.2009.07.058. Epub 2009 Jul 12.

PMID:
19643608
18.

Selectivity among dipeptidyl peptidases of the S9b family.

Bjelke JR, Kanstrup AB, Rasmussen HB.

Cell Mol Biol (Noisy-le-grand). 2006 Dec 31;52(4):3-7.

PMID:
17543192
19.

Molecular docking and 3D-QSAR studies on beta-phenylalanine derivatives as dipeptidyl peptidase IV inhibitors.

Jiang YK.

J Mol Model. 2010 Jul;16(7):1239-49. doi: 10.1007/s00894-009-0637-4. Epub 2010 Jan 13.

PMID:
20069322
20.

Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.

Ahn JH, Park WS, Jun MA, Shin MS, Kang SK, Kim KY, Rhee SD, Bae MA, Kim KR, Kim SG, Kim SY, Sohn SK, Kang NS, Lee JO, Lee DH, Cheon HG, Kim SS.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6525-9. doi: 10.1016/j.bmcl.2008.10.076. Epub 2008 Oct 21.

PMID:
18996694
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