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Results: 1 to 20 of 621

1.

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM.

J Neurosci. 2008 Jan 16;28(3):737-48. doi: 10.1523/JNEUROSCI.2824-07.2008.

PMID:
18199773
[PubMed - indexed for MEDLINE]
Free Article
2.

'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy.

Sydow A, Mandelkow EM.

Neurodegener Dis. 2010;7(1-3):28-31. doi: 10.1159/000283479. Epub 2010 Feb 13.

PMID:
20160454
[PubMed - indexed for MEDLINE]
3.

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy.

Eckermann K, Mocanu MM, Khlistunova I, Biernat J, Nissen A, Hofmann A, Schönig K, Bujard H, Haemisch A, Mandelkow E, Zhou L, Rune G, Mandelkow EM.

J Biol Chem. 2007 Oct 26;282(43):31755-65. Epub 2007 Aug 23.

PMID:
17716969
[PubMed - indexed for MEDLINE]
Free Article
4.

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.

Khlistunova I, Biernat J, Wang Y, Pickhardt M, von Bergen M, Gazova Z, Mandelkow E, Mandelkow EM.

J Biol Chem. 2006 Jan 13;281(2):1205-14. Epub 2005 Oct 24.

PMID:
16246844
[PubMed - indexed for MEDLINE]
Free Article
5.

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology.

Hochgräfe K, Sydow A, Mandelkow EM.

FEBS J. 2013 Sep;280(18):4371-81. doi: 10.1111/febs.12250. Epub 2013 Apr 22. Review.

PMID:
23517246
[PubMed - indexed for MEDLINE]
6.

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011.

PMID:
21325519
[PubMed - indexed for MEDLINE]
Free Article
7.

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM.

Acta Neuropathol. 2012 Jun;123(6):787-805. doi: 10.1007/s00401-012-0987-3. Epub 2012 Apr 25.

PMID:
22532069
[PubMed - indexed for MEDLINE]
8.

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH.

J Neurosci. 2005 Nov 16;25(46):10637-47.

PMID:
16291936
[PubMed - indexed for MEDLINE]
Free Article
9.

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.

PMID:
18490011
[PubMed - indexed for MEDLINE]
10.

Inhibition of tau aggregation in cell models of tauopathy.

Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E.

Curr Alzheimer Res. 2007 Dec;4(5):544-6. Review.

PMID:
18220518
[PubMed - indexed for MEDLINE]
11.

Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.

Pérez M, Ribe E, Rubio A, Lim F, Morán MA, Ramos PG, Ferrer I, Isla MT, Avila J.

Neuroscience. 2005;130(2):339-47.

PMID:
15664690
[PubMed - indexed for MEDLINE]
12.

Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy.

Wang Y, Krüger U, Mandelkow E, Mandelkow EM.

Neurodegener Dis. 2010;7(1-3):103-7. doi: 10.1159/000285516. Epub 2010 Feb 18.

PMID:
20173337
[PubMed - indexed for MEDLINE]
13.

Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Mol Neurosci. 2011 Nov;45(3):432-7. doi: 10.1007/s12031-011-9604-5. Epub 2011 Aug 6.

PMID:
21822709
[PubMed - indexed for MEDLINE]
14.

Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load.

Koson P, Zilka N, Kovac A, Kovacech B, Korenova M, Filipcik P, Novak M.

Eur J Neurosci. 2008 Jul;28(2):239-46. doi: 10.1111/j.1460-9568.2008.06329.x.

PMID:
18702695
[PubMed - indexed for MEDLINE]
15.

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion JP.

Neurobiol Dis. 2004 Feb;15(1):47-60.

PMID:
14751770
[PubMed - indexed for MEDLINE]
16.

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

Pérez M, Hernández F, Lim F, Díaz-Nido J, Avila J.

J Alzheimers Dis. 2003 Aug;5(4):301-8.

PMID:
14624025
[PubMed - indexed for MEDLINE]
17.

Tau filament formation in transgenic mice expressing P301L tau.

Götz J, Chen F, Barmettler R, Nitsch RM.

J Biol Chem. 2001 Jan 5;276(1):529-34.

PMID:
11013246
[PubMed - indexed for MEDLINE]
Free Article
18.

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. Epub 2002 Oct 4.

PMID:
12368474
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.

Schindowski K, Bretteville A, Leroy K, Bégard S, Brion JP, Hamdane M, Buée L.

Am J Pathol. 2006 Aug;169(2):599-616.

PMID:
16877359
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene.

Guerrero R, Navarro P, Gallego E, Garcia-Cabrero AM, Avila J, Sanchez MP.

Acta Neuropathol. 2009 Feb;117(2):159-68. doi: 10.1007/s00401-008-0470-3. Epub 2008 Dec 5.

PMID:
19057915
[PubMed - indexed for MEDLINE]
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