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Similar articles for PubMed (Select 18189346)

1.

Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.

Slee DH, Zhang X, Moorjani M, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Wen J, O'Brien Z, Saunders J.

J Med Chem. 2008 Feb 14;51(3):400-6. doi: 10.1021/jm070623o. Epub 2008 Jan 12.

PMID:
18189346
2.

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists.

Savall BM, Wu D, De Angelis M, Carruthers NI, Ao H, Wang Q, Lord B, Bhattacharya A, Letavic MA.

ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. doi: 10.1021/acsmedchemlett.5b00089. eCollection 2015 Jun 11.

PMID:
26101572
3.

Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.

Mikkelsen GK, Langgård M, Schrøder TJ, Kreilgaard M, Jørgensen EB, Brandt G, Griffon Y, Boffey R, Bang-Andersen B.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1212-6. doi: 10.1016/j.bmcl.2015.01.062. Epub 2015 Feb 7.

PMID:
25701253
4.

Optimization of 6-heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as potent adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Zheng J, Yang Z, Li X, Li L, Ma H, Wang M, Zhang H, Zhen X, Zhang X.

ACS Chem Neurosci. 2014 Aug 20;5(8):674-82. doi: 10.1021/cn5000716. Epub 2014 Jun 23.

PMID:
24922583
5.

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists.

Yang Z, Li X, Ma H, Zheng J, Zhen X, Zhang X.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):152-5. doi: 10.1016/j.bmcl.2013.11.051. Epub 2013 Dec 1.

PMID:
24332624
6.

Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.

Piersanti G, Bartoccini F, Lucarini S, Cabri W, Stasi MA, Riccioni T, Borsini F, Tarzia G, Minetti P.

J Med Chem. 2013 Jul 11;56(13):5456-63. doi: 10.1021/jm400491x. Epub 2013 Jun 24.

PMID:
23789814
7.

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.

Veinberg G, Vorona M, Zvejniece L, Vilskersts R, Vavers E, Liepinsh E, Kazoka H, Belyakov S, Mishnev A, Kuznecovs J, Vikainis S, Orlova N, Lebedev A, Ponomaryov Y, Dambrova M.

Bioorg Med Chem. 2013 May 15;21(10):2764-71. doi: 10.1016/j.bmc.2013.03.016. Epub 2013 Mar 24.

PMID:
23582449
8.

Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.

Shook BC, Chakravarty D, Barbay JK, Wang A, Leonard K, Alford V, Powell MT, Rassnick S, Scannevin RH, Carroll K, Wallace N, Crooke J, Ault M, Lampron L, Westover L, Rhodes K, Jackson PF.

Bioorg Med Chem Lett. 2013 May 1;23(9):2688-91. doi: 10.1016/j.bmcl.2013.02.078. Epub 2013 Feb 27.

PMID:
23522563
9.

Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.

Yaziji V, Rodríguez D, Coelho A, García-Mera X, El Maatougui A, Brea J, Loza MI, Cadavid MI, Gutiérrez-de-Terán H, Sotelo E.

Eur J Med Chem. 2013 Jan;59:235-42. doi: 10.1016/j.ejmech.2012.11.010. Epub 2012 Nov 24.

PMID:
23231967
10.

Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-parkinsonian agents.

Azam F, Prasad MV, Thangavel N, Shrivastava AK, Mohan G.

Med Chem. 2012 Nov;8(6):1057-68.

PMID:
22741780
11.

Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.

Baraldi PG, Saponaro G, Romagnoli R, Aghazadeh Tabrizi M, Baraldi S, Moorman AR, Cosconati S, Di Maro S, Marinelli L, Gessi S, Merighi S, Varani K, Borea PA, Preti D.

J Med Chem. 2012 Jun 14;55(11):5380-90. doi: 10.1021/jm300323t. Epub 2012 May 18.

PMID:
22568637
12.

Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.

Eles J, Beke G, Vágó I, Bozó E, Huszár J, Tarcsay A, Kolok S, Schmidt E, Vastag M, Hornok K, Farkas S, Domány G, Keserű GM.

Bioorg Med Chem Lett. 2012 May 1;22(9):3095-9. doi: 10.1016/j.bmcl.2012.03.065. Epub 2012 Mar 21.

PMID:
22483585
13.

Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.

Shook BC, Rassnick S, Wallace N, Crooke J, Ault M, Chakravarty D, Barbay JK, Wang A, Powell MT, Leonard K, Alford V, Scannevin RH, Carroll K, Lampron L, Westover L, Lim HK, Russell R, Branum S, Wells KM, Damon S, Youells S, Li X, Beauchamp DA, Rhodes K, Jackson PF.

J Med Chem. 2012 Feb 9;55(3):1402-17. doi: 10.1021/jm201640m. Epub 2012 Jan 26.

PMID:
22239465
14.

Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.

Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH.

J Med Chem. 2012 Mar 8;55(5):1898-903. doi: 10.1021/jm201376w. Epub 2012 Jan 27.

15.

Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency.

Qian W, Chen JJ, Human J, Aya T, Zhu J, Biswas K, Peterkin T, Hungate RW, Arik L, Johnson E, Kumar G, Joseph S, Jona J, Guo HX, Wu Z.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1061-7. doi: 10.1016/j.bmcl.2011.11.112. Epub 2011 Dec 8.

PMID:
22197141
16.

Synthesis and testing of a p-H2 hyperpolarized 13C probe based on the pyrazolo[1,5-a]pyrimidineacetamide DPA-713, an MRI vector to target the peripheral benzodiazepine receptors.

Cerutti E, Viale A, Damont A, Dollé F, Aime S.

Magn Reson Chem. 2011 Dec;49(12):795-800. doi: 10.1002/mrc.2839. Epub 2011 Nov 17.

PMID:
22095873
17.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.

Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

J Med Chem. 2011 Nov 10;54(21):7639-47. doi: 10.1021/jm200956q. Epub 2011 Oct 19.

18.

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

Giordanetto F, Knerr L, Selmi N, Llinàs A, Lindqvist A, Wang QD, Ståhlberg P, Thorstensson F, Ullah V, Nilsson K, O'Mahony G, Högberg G, Lindhardt E, Strand A, Duker G.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5557-61. doi: 10.1016/j.bmcl.2011.06.092. Epub 2011 Jun 30.

PMID:
21782423
19.

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan R, Craighead M, Desai H, Ho KK, MacSweeney C, Milne R, Richard Morphy J, Neagu I, Ohlmeyer MH, Pick J, Presland J, Riviello C, Zanetakos HA, Zhao J, Webb ML.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3813-7. doi: 10.1016/j.bmcl.2011.04.022. Epub 2011 Apr 13.

PMID:
21596563
20.

3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.

Chen JJ, Nguyen T, D'Amico DC, Qian W, Human J, Aya T, Biswas K, Fotsch C, Han N, Liu Q, Nishimura N, Peterkin TA, Yang K, Zhu J, Riahi BB, Hungate RW, Andersen NG, Colyer JT, Faul MM, Kamassah A, Wang J, Jona J, Kumar G, Johnson E, Askew BC.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3384-9. doi: 10.1016/j.bmcl.2011.03.115. Epub 2011 Apr 7.

PMID:
21514825
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