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Results: 1 to 20 of 116

1.

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.

Windheim M, Stafford M, Peggie M, Cohen P.

Mol Cell Biol. 2008 Mar;28(5):1783-91. doi: 10.1128/MCB.02380-06. Epub 2008 Jan 7.

PMID:
18180283
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

Ordureau A, Smith H, Windheim M, Peggie M, Carrick E, Morrice N, Cohen P.

Biochem J. 2008 Jan 1;409(1):43-52.

PMID:
17997719
[PubMed - indexed for MEDLINE]
Free Article
3.
4.

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52. doi: 10.1073/pnas.1314715110. Epub 2013 Aug 28.

PMID:
23986494
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.

Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, Li X.

Mol Cell Biol. 2012 Oct;32(19):3990-4000. doi: 10.1128/MCB.00722-12. Epub 2012 Jul 30.

PMID:
22851693
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation.

Lee HJ, Chung KC.

J Neuroinflammation. 2012 Dec 17;9:271. doi: 10.1186/1742-2094-9-271.

PMID:
23244239
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD.

Mol Cell Biol. 2008 May;28(10):3538-47. doi: 10.1128/MCB.02098-07. Epub 2008 Mar 17.

PMID:
18347055
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.

PMID:
20038579
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.

Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM.

PLoS One. 2012;7(5):e36601. doi: 10.1371/journal.pone.0036601. Epub 2012 May 8.

PMID:
22590573
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology.

Gautheron J, Pescatore A, Fusco F, Esposito E, Yamaoka S, Agou F, Ursini MV, Courtois G.

Hum Mol Genet. 2010 Aug 15;19(16):3138-49. doi: 10.1093/hmg/ddq222. Epub 2010 Jun 7.

PMID:
20529958
[PubMed - indexed for MEDLINE]
Free Article
11.

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V.

Mol Cell. 2010 Oct 8;40(1):75-86. doi: 10.1016/j.molcel.2010.09.010.

PMID:
20932476
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.

Mao R, Fan Y, Mou Y, Zhang H, Fu S, Yang J.

Cell Signal. 2011 Jan;23(1):222-7. doi: 10.1016/j.cellsig.2010.09.006. Epub 2010 Sep 16.

PMID:
20837137
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.

Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689-94. Epub 2006 Feb 13.

PMID:
16477006
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.

Sebban-Benin H, Pescatore A, Fusco F, Pascuale V, Gautheron J, Yamaoka S, Moncla A, Ursini MV, Courtois G.

Hum Mol Genet. 2007 Dec 1;16(23):2805-15. Epub 2007 Aug 29. Erratum in: Hum Mol Genet. 2008 Feb 14;17(4):639.

PMID:
17728323
[PubMed - indexed for MEDLINE]
Free Article
15.

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.

Solt LA, Madge LA, Orange JS, May MJ.

J Biol Chem. 2007 Mar 23;282(12):8724-33. Epub 2007 Jan 23.

PMID:
17244613
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation.

Fan Y, Yu Y, Mao R, Zhang H, Yang J.

Cell Signal. 2011 Apr;23(4):660-5. doi: 10.1016/j.cellsig.2010.11.017. Epub 2010 Dec 3.

PMID:
21130870
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.

Tarantino N, Tinevez JY, Crowell EF, Boisson B, Henriques R, Mhlanga M, Agou F, Israël A, Laplantine E.

J Cell Biol. 2014 Jan 20;204(2):231-45. doi: 10.1083/jcb.201307172.

PMID:
24446482
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.

EMBO J. 2008 Jan 23;27(2):373-83. Epub 2007 Dec 13.

PMID:
18079694
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

PMID:
17135271
[PubMed - indexed for MEDLINE]
Free PMC Article

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