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Results: 1 to 20 of 194

Similar articles for PubMed (Select 18079394)

1.

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM.

Science. 2007 Dec 14;318(5857):1744-8.

2.

A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.

Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. doi: 10.1073/pnas.0908444106. Epub 2009 Sep 23.

4.

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

Pirola L, Zvelebil MJ, Bulgarelli-Leva G, Van Obberghen E, Waterfield MD, Wymann MP.

J Biol Chem. 2001 Jun 15;276(24):21544-54. Epub 2001 Feb 13.

5.

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.

Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18443-8. Epub 2005 Dec 8.

6.

Human tumor mutants in the p110alpha subunit of PI3K.

Liu Z, Roberts TM.

Cell Cycle. 2006 Apr;5(7):675-7. Epub 2006 Apr 1. Review.

PMID:
16627990
7.

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL.

Science. 2007 Jul 13;317(5835):239-42.

8.

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.

Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, Dhanak D, Copeland RA, Gontarek RR, Tummino PJ, Luo L.

Biochem J. 2008 Jan 15;409(2):519-24.

PMID:
17877460
9.
10.

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR.

Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. doi: 10.1016/j.bbrc.2009.02.081. Epub 2009 Feb 20.

PMID:
19233141
11.

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.

Hon WC, Berndt A, Williams RL.

Oncogene. 2012 Aug 9;31(32):3655-66. doi: 10.1038/onc.2011.532. Epub 2011 Nov 28.

12.

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Huang CH, Mandelker D, Gabelli SB, Amzel LM.

Cell Cycle. 2008 May 1;7(9):1151-6. Epub 2008 Feb 27. Review.

13.

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms.

Zhao L, Vogt PK.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2652-7. doi: 10.1073/pnas.0712169105. Epub 2008 Feb 11.

14.

Rare cancer-specific mutations in PIK3CA show gain of function.

Gymnopoulos M, Elsliger MA, Vogt PK.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5569-74. Epub 2007 Mar 21.

16.

Oncogenic mutations of PIK3CA in human cancers.

Samuels Y, Velculescu VE.

Cell Cycle. 2004 Oct;3(10):1221-4. Epub 2004 Oct 12.

PMID:
15467468
17.

The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function.

Beeton CA, Das P, Waterfield MD, Shepherd PR.

Mol Cell Biol Res Commun. 1999 May;1(2):153-7.

PMID:
10356365
18.

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket.

Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM.

J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20.

19.

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Sun M, Hillmann P, Hofmann BT, Hart JR, Vogt PK.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52. doi: 10.1073/pnas.1009652107. Epub 2010 Aug 16.

20.

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM.

J Biol Chem. 2005 Jul 29;280(30):27850-5. Epub 2005 Jun 2.

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