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Items: 1 to 20 of 105


The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.

Munoz MA, Saunders DN, Henderson MJ, Clancy JL, Russell AJ, Lehrbach G, Musgrove EA, Watts CK, Sutherland RL.

Cell Cycle. 2007 Dec 15;6(24):3070-7. Epub 2007 Sep 7.


EDD mediates DNA damage-induced activation of CHK2.

Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK.

J Biol Chem. 2006 Dec 29;281(52):39990-40000. Epub 2006 Oct 30.


A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB.

PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287.


Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.

Zimmermann M, Arachchige-Don AS, Donaldson MS, Dallapiazza RF, Cowan CE, Horne MC.

J Biol Chem. 2012 Jun 29;287(27):22838-53. doi: 10.1074/jbc.M112.376855. Epub 2012 May 15.


Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.

Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA.

Mol Cell Biol. 2010 Jul;30(13):3371-83. doi: 10.1128/MCB.01644-09. Epub 2010 Apr 26.


The limitations of the G1-S checkpoint.

Deckbar D, Stiff T, Koch B, Reis C, Löbrich M, Jeggo PA.

Cancer Res. 2010 Jun 1;70(11):4412-21. doi: 10.1158/0008-5472.CAN-09-3198. Epub 2010 May 11.


Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.

Xu B, Kim ST, Lim DS, Kastan MB.

Mol Cell Biol. 2002 Feb;22(4):1049-59.


Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.

Liu H, Takeda S, Kumar R, Westergard TD, Brown EJ, Pandita TK, Cheng EH, Hsieh JJ.

Nature. 2010 Sep 16;467(7313):343-6. doi: 10.1038/nature09350. Epub 2010 Sep 5.


DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.

Zhang WH, Poh A, Fanous AA, Eastman A.

Cell Cycle. 2008 Jun 1;7(11):1668-77. Epub 2008 Mar 23.


EDD inhibits ATM-mediated phosphorylation of p53.

Ling S, Lin WC.

J Biol Chem. 2011 Apr 29;286(17):14972-82. doi: 10.1074/jbc.M110.182527. Epub 2011 Mar 7.


The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity.

Krueger SA, Wilson GD, Piasentin E, Joiner MC, Marples B.

Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1509-17. doi: 10.1016/j.ijrobp.2010.01.028.


The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.

Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G.

Oncogene. 2004 May 27;23(25):4353-61.


EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.

Scialpi F, Mellis D, Ditzel M.

J Biol Chem. 2015 May 15;290(20):12585-94. doi: 10.1074/jbc.M114.625673. Epub 2015 Apr 1.


no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.

Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA.

Development. 2009 Feb;136(3):449-59. doi: 10.1242/dev.027599.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.


The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

Löbrich M, Jeggo PA.

Nat Rev Cancer. 2007 Nov;7(11):861-9. Review.


Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, Brown KD, Zhang L, Baskaran R.

J Biol Chem. 2004 Jun 11;279(24):25813-22. Epub 2004 Apr 8.


A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.

Varmark H, Kwak S, Theurkauf WE.

Cell Cycle. 2010 Jan 15;9(2):312-20. Epub 2010 Jan 23.

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