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Results: 1 to 20 of 363

1.

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.

Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9.

PMID:
18037290
[PubMed - indexed for MEDLINE]
2.

Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.

Yue EW, Wayland B, Douty B, Crawley ML, McLaughlin E, Takvorian A, Wasserman Z, Bower MJ, Wei M, Li Y, Ala PJ, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP.

Bioorg Med Chem. 2006 Sep 1;14(17):5833-49.

PMID:
16769216
[PubMed - indexed for MEDLINE]
3.

Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors.

Sparks RB, Polam P, Zhu W, Crawley ML, Takvorian A, McLaughlin E, Wei M, Ala PJ, Gonneville L, Taylor N, Li Y, Wynn R, Burn TC, Liu PC, Combs AP.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):736-40. Epub 2006 Oct 28.

PMID:
17097290
[PubMed - indexed for MEDLINE]
4.

Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, McLaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R.

J Biol Chem. 2006 Dec 8;281(49):38013-21. Epub 2006 Oct 6.

PMID:
17028182
[PubMed - indexed for MEDLINE]
Free Article
5.

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.

Combs AP, Yue EW, Bower M, Ala PJ, Wayland B, Douty B, Takvorian A, Polam P, Wasserman Z, Zhu W, Crawley ML, Pruitt J, Sparks R, Glass B, Modi D, McLaughlin E, Bostrom L, Li M, Galya L, Blom K, Hillman M, Gonneville L, Reid BG, Wei M, Becker-Pasha M, Klabe R, Huber R, Li Y, Hollis G, Burn TC, Wynn R, Liu P, Metcalf B.

J Med Chem. 2005 Oct 20;48(21):6544-8.

PMID:
16220970
[PubMed - indexed for MEDLINE]
6.

Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.

Combs AP, Zhu W, Crawley ML, Glass B, Polam P, Sparks RB, Modi D, Takvorian A, McLaughlin E, Yue EW, Wasserman Z, Bower M, Wei M, Rupar M, Ala PJ, Reid BM, Ellis D, Gonneville L, Emm T, Taylor N, Yeleswaram S, Li Y, Wynn R, Burn TC, Hollis G, Liu PC, Metcalf B.

J Med Chem. 2006 Jun 29;49(13):3774-89.

PMID:
16789735
[PubMed - indexed for MEDLINE]
7.

Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.

Houssin R, Pommery J, Salaün MC, Deweer S, Goossens JF, Chavatte P, Hénichart JP.

J Med Chem. 2002 Jan 17;45(2):533-6.

PMID:
11784157
[PubMed - indexed for MEDLINE]
8.

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039. Epub 2008 Apr 22.

PMID:
18482836
[PubMed - indexed for MEDLINE]
9.

Synthesis, structure-activity relationship and docking studies of substituted aryl thiazolyl phenylsulfonamides as potential protein tyrosine phosphatase 1B inhibitors.

Varshney K, Gupta S, Rahuja N, Rawat AK, Singh N, Tamarkar AK, Srivastava AK, Saxena AK.

ChemMedChem. 2012 Jul;7(7):1185-90. doi: 10.1002/cmdc.201200197. Epub 2012 May 21. No abstract available.

PMID:
22615198
[PubMed - indexed for MEDLINE]
10.

Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.

Wan ZK, Lee J, Hotchandani R, Moretto A, Binnun E, Wilson DP, Kirincich SJ, Follows BC, Ipek M, Xu W, Joseph-McCarthy D, Zhang YL, Tam M, Erbe DV, Tobin JF, Li W, Tam SY, Mansour TS, Wu J.

ChemMedChem. 2008 Oct;3(10):1525-9. doi: 10.1002/cmdc.200800188. No abstract available.

PMID:
18798205
[PubMed - indexed for MEDLINE]
11.

Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents.

Li HY, DeLucca I, Boswell GA, Billheimer JT, Drummond S, Gillies PJ, Robinson C.

Bioorg Med Chem. 1997 Jul;5(7):1345-61.

PMID:
9377095
[PubMed - indexed for MEDLINE]
12.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J.

Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

PMID:
15863305
[PubMed - indexed for MEDLINE]
13.

Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling.

Bharatham K, Bharatham N, Kwon YJ, Lee KW.

J Comput Aided Mol Des. 2008 Dec;22(12):925-33. doi: 10.1007/s10822-008-9229-0. Epub 2008 Aug 7.

PMID:
18685809
[PubMed - indexed for MEDLINE]
14.

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. Epub 2006 Jun 27.

PMID:
16806920
[PubMed - indexed for MEDLINE]
15.

Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.

Chen YT, Tang CL, Ma WP, Gao LX, Wei Y, Zhang W, Li JY, Li J, Nan FJ.

Eur J Med Chem. 2013 Nov;69:399-412. doi: 10.1016/j.ejmech.2013.09.017. Epub 2013 Sep 19.

PMID:
24090912
[PubMed - indexed for MEDLINE]
16.

Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

Rawls KA, Grundner C, Ellman JA.

Org Biomol Chem. 2010 Sep 21;8(18):4066-70. doi: 10.1039/c0ob00182a. Epub 2010 Jul 19.

PMID:
20644889
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL.

Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4.

PMID:
12699757
[PubMed - indexed for MEDLINE]
18.

Rationalizing protein-ligand interactions for PTP1B inhibitors using computational methods.

Ajmani S, Karanam S, Kulkarni SA.

Chem Biol Drug Des. 2009 Dec;74(6):582-95. doi: 10.1111/j.1747-0285.2009.00894.x. Epub 2009 Oct 12.

PMID:
19824894
[PubMed - indexed for MEDLINE]
19.

Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies.

Shim YS, Kim KC, Lee KA, Shrestha S, Lee KH, Kim CK, Cho H.

Bioorg Med Chem. 2005 Feb 15;13(4):1325-32.

PMID:
15670940
[PubMed - indexed for MEDLINE]
20.

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

Qiu WW, Shen Q, Yang F, Wang B, Zou H, Li JY, Li J, Tang J.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. doi: 10.1016/j.bmcl.2009.10.017. Epub 2009 Oct 8.

PMID:
19846303
[PubMed - indexed for MEDLINE]

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