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RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.

Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL.

J Endocrinol. 2007 Nov;195(2):313-21.


Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.

Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin LS, Leapman RD, Notkins AL.

Diabetologia. 2011 Sep;54(9):2347-57. doi: 10.1007/s00125-011-2221-6. Epub 2011 Jul 6.


Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81. doi: 10.1677/JOE-07-0496.


The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.


Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.

Masjkur J, Arps-Forker C, Poser SW, Nikolakopoulou P, Toutouna L, Chenna R, Chavakis T, Chatzigeorgiou A, Chen LS, Dubrovska A, Choudhary P, Uphues I, Mark M, Bornstein SR, Androutsellis-Theotokis A.

J Biol Chem. 2014 Dec 19;289(51):35503-16. doi: 10.1074/jbc.M114.590687. Epub 2014 Nov 4.


The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.

Caromile LA, Oganesian A, Coats SA, Seifert RA, Bowen-Pope DF.

J Biol Chem. 2010 Apr 2;285(14):10487-96. doi: 10.1074/jbc.M109.066563. Epub 2010 Jan 22.


Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

Diabetes. 2004 Jul;53(7):1684-91.


Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells.

Varadi A, Tsuboi T, Rutter GA.

Mol Biol Cell. 2005 Jun;16(6):2670-80. Epub 2005 Mar 23.


IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.


Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.

Kawakami T, Saeki K, Takeyama N, Wu G, Sakudo A, Matsumoto Y, Hayashi T, Onodera T.

Int J Mol Med. 2007 Aug;20(2):177-85.


IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.

Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC.

J Comp Neurol. 2001 Jan 1;429(1):127-43.


A neuroendocrine-specific protein localized to the endoplasmic reticulum by distal degradation.

Schiller MR, Mains RE, Eipper BA.

J Biol Chem. 1995 Nov 3;270(44):26129-38.


Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

Kubosaki A, Nakamura S, Notkins AL.

Diabetes. 2005 Dec;54 Suppl 2:S46-51.


In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion.

Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M.

J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206. Epub 2006 Sep 19.


Surface and intracellular Fas expression associated with cytokine-induced apoptosis in rodent islet and insulinoma cells.

Augstein P, Wachlin G, Berg S, Bahr J, Salzsieder C, Hehmke B, Heinke P, Salzsieder E.

J Mol Endocrinol. 2003 Apr;30(2):163-71.


Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Schvartz D, Couté Y, Brunner Y, Wollheim CB, Sanchez JC.

Mol Cell Proteomics. 2012 Aug;11(8):244-54. doi: 10.1074/mcp.M112.018051. Epub 2012 Mar 16.


Fas ligand down-regulates cytokine-induced Fas receptor expression on insulinoma (NIT-1), but not islet cells, from autoimmune nonobese diabetic mice.

Augstein P, Heinke P, Salzsieder E, Berg S, Rettig R, Salzsieder C, Harrison LC.

Endocrinology. 2004 Jun;145(6):2747-52. Epub 2004 Mar 19.


Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

Seissler J, Nguyen TB, Aust G, Steinbrenner H, Scherbaum WA.

Diabetes. 2000 Jul;49(7):1137-41.

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