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Items: 1 to 20 of 104

1.

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.

Reigan P, Gbaj A, Stratford IJ, Bryce RA, Freeman S.

Eur J Med Chem. 2008 Jun;43(6):1248-60. Epub 2007 Aug 6.

PMID:
17870212
2.

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

Reigan P, Gbaj A, Chinje E, Stratford IJ, Douglas KT, Freeman S.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5247-50.

PMID:
15454205
3.

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S.

J Med Chem. 2005 Jan 27;48(2):392-402.

PMID:
15658853
4.

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

Cole C, Reigan P, Gbaj A, Edwards PN, Douglas KT, Stratford IJ, Freeman S, Jaffar M.

J Med Chem. 2003 Jan 16;46(2):207-9.

PMID:
12519058
5.

Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.

McNally VA, Rajabi M, Gbaj A, Stratford IJ, Edwards PN, Douglas KT, Bryce RA, Jaffar M, Freeman S.

J Pharm Pharmacol. 2007 Apr;59(4):537-47.

PMID:
17430637
6.

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).

Bronckaers A, Aguado L, Negri A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ, Gago F, Liekens S.

Biochem Pharmacol. 2009 Aug 1;78(3):231-40. doi: 10.1016/j.bcp.2009.04.011. Epub 2009 Apr 21.

PMID:
19389384
7.

Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy.

Liekens S, Bronckaers A, Pérez-Pérez MJ, Balzarini J.

Biochem Pharmacol. 2007 Dec 3;74(11):1555-67. Epub 2007 May 16. Review.

PMID:
17572389
8.

The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.

Cole C, Foster AJ, Freeman S, Jaffar M, Murray PE, Strafford IJ.

Anticancer Drug Des. 1999 Oct;14(5):383-92. Review.

PMID:
10766293
9.

Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase.

Klein RS, Lenzi M, Lim TH, Hotchkiss KA, Wilson P, Schwartz EL.

Biochem Pharmacol. 2001 Nov 1;62(9):1257-63.

PMID:
11705459
10.

Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.

Rajabi M, Mansell D, Freeman S, Bryce RA.

Eur J Med Chem. 2011 Apr;46(4):1165-71. doi: 10.1016/j.ejmech.2011.01.035. Epub 2011 Jan 31.

PMID:
21324566
11.

Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo.

Tsukagoshi S, Saga Y, Suzuki N, Fujioka A, Nakagawa F, Fukushima M, Suzuki M.

Int J Oncol. 2003 May;22(5):961-7.

PMID:
12684660
12.
13.

Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones.

Bera H, Lee MH, Sun L, Dolzhenko AV, Chui WK.

Bioorg Chem. 2013 Oct;50:34-40. doi: 10.1016/j.bioorg.2013.07.004. Epub 2013 Aug 2.

PMID:
23968897
14.

Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase.

Allan AL, Gladstone PL, Price ML, Hopkins SA, Juarez JC, Doñate F, Ternansky RJ, Shaw DE, Ganem B, Li Y, Wang W, Ealick S.

J Med Chem. 2006 Dec 28;49(26):7807-15.

PMID:
17181163
15.

The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression.

Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S, Haraguchi M.

Cancer Sci. 2004 Nov;95(11):851-7. Review.

16.

In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.

Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K.

Nucl Med Biol. 2010 May;37(4):427-32. doi: 10.1016/j.nucmedbio.2010.01.005. Epub 2010 Apr 8.

PMID:
20447553
17.

Thymidine phosphorylase inhibitors with a homophthalimide skeleton.

Kita T, Takahashi H, Hashimoto Y.

Biol Pharm Bull. 2001 Jul;24(7):860-2.

18.

Angiogenic factor thymidine phosphorylase increases cancer cell invasion activity in patients with gastric adenocarcinoma.

Yu EJ, Lee Y, Rha SY, Kim TS, Chung HC, Oh BK, Yang WI, Noh SH, Jeung HC.

Mol Cancer Res. 2008 Oct;6(10):1554-66. doi: 10.1158/1541-7786.MCR-08-0166.

19.

Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion.

Jones A, Fujiyama C, Turner K, Cranston D, Williams K, Stratford I, Bicknell R, Harris AL.

J Urol. 2002 Mar;167(3):1482-6.

PMID:
11832774
20.

The dual role of thymidine phosphorylase in cancer development and chemotherapy.

Bronckaers A, Gago F, Balzarini J, Liekens S.

Med Res Rev. 2009 Nov;29(6):903-53. doi: 10.1002/med.20159. Review.

PMID:
19434693
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