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17867331,20088400,10341399,16388509,16245371,17269128,12673635,30950006,33447994,12420837,18512854,16601335,18461550,20301994,19306471,19189527,18432600,11432311,18726925,24444556,17077242,12628267,16952214,20658511,16088864,19526452,22324916,19133038,15507981,19222026,23289277,22611005,15507982,28295158,31710734,8863700,16104673,15802030,30919147,19402101,22752980,15228997,17346554,20687123,23494847,12566186,22536640,21611995,15057947,11481959,16946227,19288535,18544579,19248005,15503268,15736185,12210583,32621353,25297598,15736186,18835870,21062401,20503223,16282175,16892462,32977750,22365285,16752230,7538782,9746387,16240322,25546923,23887070,22807155,12210572,12230441,21793085,9521983,15719038,17590888,17171632,18186136,17999381,15229844,17286311,20505946,21400623,19031473,10360515,19106261,11425838,15906426,16225579,17992705,10694680,21485734,23080546,10951481,25864278,12422904,12118646,34645361,10861716,16644613,36036240,22377654,10589062,34038977,23881389,10951484,11920896,16374753,24155168,23891271,11746159,11920903,26117974,10820406,31569431,29683008,11559904,28702698,29057435,10327142,14534333,21870022,30318933,11559905,35294217,9203211,28099747,11702835,35595434,26538356,11028580,34872079,11559909,32811232,25030727,9793972,28553771,14559038,27549925,15295343,28640470,17426792,10416963,21576269,20192924,24177714,20121529,24356462,30666005,16013176,29396076,9209792,15844559,24032275,20476599,27958633,35402610,12204419,10589055,24906955,30122577,9516016,21895614,14669430,26726121,25118506,11028579,7519773,30156700,27430153,9006816,10085510,7540431,26785129,7508624,29781076,32456488,31029970,25877605,33128403,26559420,27569022,10416962,19416569,20120938,28006080,33206412,28925570,22886467,12635737,24411037,8623793,25543334,21671890,25864262,36706659,11499055,7533285,22954283,23245345,27391901,27403933,32266955,27530061,22274905,24338604,14594321,31335241,15961547,12948096,36498421,23426428,10551789,26054128,24192610,8863698,25688936,25044397,24381414,27627592,19888042,28419502,28771606,30371129,34750768,30367479,19541861,14968021,28514830,8652486,28451695,35339997,29226487,32228094,32495931,8710764,33823722,35667377,21793280,31232018,10740204,29216009,10073898,11920899,35620869,20593975,18306921,10381824,24731729,30581343,11461021,32777901,31801467,10986441,9197882,33301164,30049248,30048548,21495804,26892697,36908009,14712947,35414612,24021593,24455857,32292079,28718082,24333205,17057931,28377328,11861437,26367380,27809614,33603798,32039494,7537878,28876771,33207975,8988688,9294599,31343977,23800388,10762294,7528054,23700843,19589172,24813486,32849925,9091018,36989429,12393965,33957116,36468756,23172596,21241202,24899320,9467807,15032969,21043823,31152694,19034930,23855638,8743141,15181877,21867405,24591935,32176639,11038453,35663689,29262756,8587866,31347423,8968236,11589683,18946222,23169109,24342366,27597552,20936638,15181875,24193697,26581188,32525124,27442264,31122094,26524810,25218268,9988824,24195065,11914564,24499760,18615547,33559011,7479592,35144584,35603424,30901484,27185470,11015713,25097629,23172419,7531330,32761738,15181876,28792712,28133835,9793970,29439729,35727579,11038452,18314514,26492710,24395037,29157037,6188479,8735748,30539731,16282776,7612531,21564478,11750960,1376387,9070141,6169364,28733063,15181881,34159403,34107630,18923756,26237386,31855125,27743407,19507559,24907361,31037917,24327477,11262989,27561595,22126420,29051781,11858885,28009332,35411996,16682761,22649294,9849008,7684254,27304657,34541644,9475366,36778751,27739239,7479591,7503590,9579443,22166275,36691372,31598043,35894505,27582529,31634590,10426246,23653992,30288169,19085637,23537299,30206047,28514925,21150163,27925703,26266002,24991215,36288842,36617200,11704143,15976112,25132703,28752144,23353022,34592002,36511600,28326518,20356939,35303658,29723400,29034302,27567433,2531546,16470729,29642747,2961264,28457106,17378127,6177337,7692431,21877143,8623792,30011404,32683755,22460245,31706055,16391341,24917922,11750741,9077605,9439450,30378348,2762231,37108840,33218397,2438195,35706851,25691414,24757339,30669906,23401929,28556194,36056230,29060631,29503259,26929762,26527976,36550920,27093520,7684957,10426620,33618603,8863715,2480155,36246716,26673632,34434280,27278979,28698954,25864254,9061762,28126630,24592029,27668198,1379094,2409861,11975975,25031576,29391672,27709449,27183961,24992789,29207696,12220777,2408927,14667886,27718286,24069146,35268281,31696754,27299851,8671345,10861715,14756735,27966372,23354850,31758302,35384772,21391873,2457210,26754341,8530683,28058348,19643791,29779040,36721559,9363238,37048586,28753549,25476813,23304682,23741540,7507132,24767647,1382770,1382769,33818248,8495760,2459901,36743865,22675970,35407545,8671349,20638576,31092068,21070127,24948981,15017349,28934815,31391722,2478398,30122131,17657519,17363418,24586333,36442168,27277632,22102486,2425794,7533288,16050000,37062114,26237489,32118472,35914755,28724324,14664408,24505955,29295662,9475363,36817855,2417443,9209900,19894468,7093168,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[Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation--Polish multi-centre research].

Borowski D, Czuba B, Cnota W, Hincz P, Czekierdowski A, Gajewska J, Jaczyńska R, Ceran A, Włoch A, Wyrwas D, Wiełgoś M, Szymusik I, Szaflik K, Sodowski K. Borowski D, et al. Ginekol Pol. 2007 May;78(5):384-7. Ginekol Pol. 2007. PMID: 17867331 Polish.

[Noninvasive prenatal test in the first trimester of pregnancy (NT and estimation of beta-hCG and PAPP-A) in the diagnosis of fetal abnormalities in Polish population--comparison of the biochemistry own normal ranges and literature reported data].

Mandryka-Stankewycz S, Perenc M, Dec G, Sieroszewski P. Mandryka-Stankewycz S, et al. Ginekol Pol. 2009 Nov;80(11):851-5. Ginekol Pol. 2009. PMID: 20088400 Polish.

A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A.

Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH. Spencer K, et al. Ultrasound Obstet Gynecol. 1999 Apr;13(4):231-7. doi: 10.1046/j.1469-0705.1999.13040231.x. Ultrasound Obstet Gynecol. 1999. PMID: 10341399 Free article. Clinical Trial.

Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks.

Falcon O, Auer M, Gerovassili A, Spencer K, Nicolaides KH. Falcon O, et al. Ultrasound Obstet Gynecol. 2006 Feb;27(2):151-5. doi: 10.1002/uog.2699. Ultrasound Obstet Gynecol. 2006. PMID: 16388509 Free article.

Maternal serum biochemistry at 11-13(+6) weeks in relation to the presence or absence of the fetal nasal bone on ultrasonography in chromosomally abnormal fetuses: an updated analysis of integrated ultrasound and biochemical screening.

Cicero S, Spencer K, Avgidou K, Faiola S, Nicolaides KH. Cicero S, et al. Prenat Diagn. 2005 Nov;25(11):977-83. doi: 10.1002/pd.1211. Prenat Diagn. 2005. PMID: 16245371

Maternal serum free-beta-chorionic gonadotrophin, pregnancy-associated plasma protein-A and fetal nuchal translucency thickness at 10-13(+6) weeks in relation to co-variables in pregnant Saudi women.

Ardawi MS, Nasrat HA, Rouzi AA, Qari MH, Al-Qahtani MH, Abuzenadah AM. Ardawi MS, et al. Prenat Diagn. 2007 Apr;27(4):303-11. doi: 10.1002/pd.1661. Prenat Diagn. 2007. PMID: 17269128

Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free beta-hCG and PAPP-A at 11 to 14 weeks.

Cicero S, Bindra R, Rembouskos G, Spencer K, Nicolaides KH. Cicero S, et al. Prenat Diagn. 2003 Apr;23(4):306-10. doi: 10.1002/pd.588. Prenat Diagn. 2003. PMID: 12673635

The clinical usefulness of biochemical (free β-hCg, PaPP-a) and ultrasound (nuchal translucency) parameters in prenatal screening of trisomy 21 in the first trimester of pregnancy.

Ziolkowska K, Dydowicz P, Sobkowski M, Tobola-Wrobel K, Wysocka E, Pietryga M. Ziolkowska K, et al. Ginekol Pol. 2019;90(3):161-166. doi: 10.5603/GP.2019.0029. Ginekol Pol. 2019. PMID: 30950006 Free article.

The significance of maternal blood pregnancy-associated plasma protein A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (β-hCG) levels for the risk assessment of fetal trisomy 18 during the first prenatal testing between 11 and 13+6 weeks of pregnancy.

Ziolkowska K, Tobola-Wrobel K, Dydowicz P, Zurawski S, Pietryga M, Wysocka E. Ziolkowska K, et al. Ginekol Pol. 2020;91(12):748-754. doi: 10.5603/GP.a2020.0126. Ginekol Pol. 2020. PMID: 33447994 Free article.

Screening for trisomy 21 by maternal age, fetal nuchal translucency and maternal serum biochemistry at 11-14 weeks: a German multicenter study.

von Kaisenberg CS, Gasiorek-Wiens A, Bielicki M, Bahlmann F, Meyberg H, Kossakiewicz A, Pruggmayer M, Kamin G, Fritzer E, Harris C, Arnold N; German Speaking Down Syndrome Screening Group. von Kaisenberg CS, et al. J Matern Fetal Neonatal Med. 2002 Aug;12(2):89-94. doi: 10.1080/jmf.12.2.89.94. J Matern Fetal Neonatal Med. 2002. PMID: 12420837

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