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Items: 1 to 20 of 89

1.

Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J 3rd, Montminy M.

Nature. 2007 Sep 20;449(7160):366-9. Epub 2007 Sep 5.

PMID:
17805301
2.

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.

3.

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M.

Nature. 2005 Oct 20;437(7062):1109-11. Epub 2005 Sep 7.

PMID:
16148943
4.

Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling.

Canettieri G, Koo SH, Berdeaux R, Heredia J, Hedrick S, Zhang X, Montminy M.

Cell Metab. 2005 Nov;2(5):331-8.

5.

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.

Muraoka M, Fukushima A, Viengchareun S, Lomb├Ęs M, Kishi F, Miyauchi A, Kanematsu M, Doi J, Kajimura J, Nakai R, Uebi T, Okamoto M, Takemori H.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1430-9. doi: 10.1152/ajpendo.00024.2009. Epub 2009 Apr 7.

6.

Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.

Uebi T, Tamura M, Horike N, Hashimoto YK, Takemori H.

Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E413-25. doi: 10.1152/ajpendo.00525.2009. Epub 2010 Jun 15.

7.

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M.

Nature. 2012 Apr 8;485(7396):128-32. doi: 10.1038/nature10988.

8.

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR 3rd, Takemori H, Okamoto M, Montminy M.

Cell. 2004 Oct 1;119(1):61-74.

9.

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.

Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P.

World J Gastroenterol. 2015 Jul 7;21(25):7777-85. doi: 10.3748/wjg.v21.i25.7777.

10.

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.

Jansson D, Ng AC, Fu A, Depatie C, Al Azzabi M, Screaton RA.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10161-6. doi: 10.1073/pnas.0800796105. Epub 2008 Jul 14.

11.

More TORC for the gluconeogenic engine.

Cheng A, Saltiel AR.

Bioessays. 2006 Mar;28(3):231-4.

PMID:
16479585
12.

Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice.

De Souza CT, Frederico MJ, da Luz G, Cintra DE, Ropelle ER, Pauli JR, Velloso LA.

J Physiol. 2010 Jun 15;588(Pt 12):2239-53. doi: 10.1113/jphysiol.2009.183996. Epub 2010 Apr 26.

13.

Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss.

Marinho R, Ropelle ER, Cintra DE, De Souza CT, Da Silva AS, Bertoli FC, Colantonio E, D'Almeida V, Pauli JR.

J Cell Physiol. 2012 Jul;227(7):2917-26. doi: 10.1002/jcp.23037.

PMID:
21938726
14.

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

Caton PW, Nayuni NK, Kieswich J, Khan NQ, Yaqoob MM, Corder R.

J Endocrinol. 2010 Apr;205(1):97-106. doi: 10.1677/JOE-09-0345. Epub 2010 Jan 21.

15.

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.

Wang Y, Vera L, Fischer WH, Montminy M.

Nature. 2009 Jul 23;460(7254):534-7. doi: 10.1038/nature08111. Epub 2009 Jun 21.

16.

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.

17.

COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.

Kato S, Ding J, Pisck E, Jhala US, Du K.

J Biol Chem. 2008 Dec 19;283(51):35464-73. doi: 10.1074/jbc.M801011200. Epub 2008 Sep 24.

18.

TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.

Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH.

Cell Metab. 2009 Mar;9(3):240-51. doi: 10.1016/j.cmet.2009.01.007.

19.

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2.

Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M.

J Biol Chem. 2015 Oct 23;290(43):25997-6006. doi: 10.1074/jbc.M115.679266. Epub 2015 Sep 4.

PMID:
26342077
20.

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.

Nature. 2003 May 29;423(6939):550-5. Epub 2003 May 18.

PMID:
12754525
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