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Items: 1 to 20 of 223

1.

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.

Coleman PJ, Schreier JD, Cox CD, Fraley ME, Garbaccio RM, Buser CA, Walsh ES, Hamilton K, Lobell RB, Rickert K, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo L, Prueksaritanont T, Li C, Mahan EA, Fernandez-Metzler C, Salata JJ, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5390-5. Epub 2007 Aug 6.

PMID:
17761419
2.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

Roecker AJ, Coleman PJ, Mercer SP, Schreier JD, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo LC, Li C, Fernandez-Metzler C, Mahan EA, Prueksaritanont T, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5677-82. Epub 2007 Aug 21.

PMID:
17766111
3.

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Cox CD, Torrent M, Breslin MJ, Mariano BJ, Whitman DB, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Schaber MD, Lobell RB, Tao W, South VJ, Kohl NE, Yan Y, Kuo LC, Prueksaritanont T, Slaughter DE, Li C, Mahan E, Lu B, Hartman GD.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3175-9. Epub 2006 Apr 5.

PMID:
16603356
4.

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5.

PMID:
15808464
5.

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.

Garbaccio RM, Tasber ES, Neilson LA, Coleman PJ, Fraley ME, Olson C, Bergman J, Torrent M, Buser CA, Rickert K, Walsh ES, Hamilton K, Lobell RB, Tao W, South VJ, Diehl RE, Davide JP, Yan Y, Kuo LC, Li C, Prueksaritanont T, Fernandez-Metzler C, Mahan EA, Slaughter DE, Salata JJ, Kohl NE, Huber HE, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5671-6. Epub 2007 Aug 21.

PMID:
17804233
6.

KSP inhibitors as antimitotic agents.

Pérez-Melero C.

Curr Top Med Chem. 2014;14(20):2286-311. Review.

PMID:
25434354
7.

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

Fraley ME, Garbaccio RM, Arrington KL, Hoffman WF, Tasber ES, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Fernandes C, Schaber MD, Lobell RB, Tao W, South VJ, Yan Y, Kuo LC, Prueksaritanont T, Shu C, Torrent M, Heimbrook DC, Kohl NE, Huber HE, Hartman GD.

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1775-9. Epub 2006 Jan 24.

PMID:
16439123
8.

Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.

Cox CD, Breslin MJ, Whitman DB, Coleman PJ, Garbaccio RM, Fraley ME, Zrada MM, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao W, Abrams MT, South VJ, Huber HE, Kohl NE, Hartman GD.

Bioorg Med Chem Lett. 2007 May 15;17(10):2697-702. Epub 2007 Mar 6.

PMID:
17395460
9.

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. Epub 2007 Apr 29.

PMID:
17498954
10.

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.

Garbaccio RM, Fraley ME, Tasber ES, Olson CM, Hoffman WF, Arrington KL, Torrent M, Buser CA, Walsh ES, Hamilton K, Schaber MD, Fernandes C, Lobell RB, Tao W, South VJ, Yan Y, Kuo LC, Prueksaritanont T, Slaughter DE, Shu C, Heimbrook DC, Kohl NE, Huber HE, Hartman GD.

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1780-3. Epub 2006 Jan 24.

PMID:
16439122
11.

Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors.

Jiang C, You Q, Liu F, Wu W, Guo Q, Chern J, Yang L, Chen M.

Chem Pharm Bull (Tokyo). 2009 Jun;57(6):567-71.

12.

Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.

Takeuchi T, Oishi S, Kaneda M, Misu R, Ohno H, Sawada J, Asai A, Nakamura S, Nakanishi I, Fujii N.

Bioorg Med Chem. 2014 Jun 15;22(12):3171-9. doi: 10.1016/j.bmc.2014.04.008. Epub 2014 Apr 13.

PMID:
24794744
13.

Novel ATP-competitive kinesin spindle protein inhibitors.

Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, Knight SD, Luo L, Moore ML, Newlander KA, Ridgers LH, Sakowicz R, Shaw AN, Sung CM, Sutton D, Wood KW, Zhang SY, Zimmerman MN, Dhanak D.

J Med Chem. 2007 Oct 4;50(20):4939-52. Epub 2007 Aug 29.

PMID:
17725339
14.

Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.

Matsuno K, Sawada J, Sugimoto M, Ogo N, Asai A.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. doi: 10.1016/j.bmcl.2009.01.018. Epub 2009 Jan 11.

PMID:
19167222
15.

New chemical tools for investigating human mitotic kinesin Eg5.

Klein E, DeBonis S, Thiede B, Skoufias DA, Kozielski F, Lebeau L.

Bioorg Med Chem. 2007 Oct 1;15(19):6474-88. Epub 2007 Jun 10.

PMID:
17587586
16.

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F.

J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n.

PMID:
20597485
17.

Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Liu F, Yu LQ, Jiang C, Yang L, Wu WT, You QD.

Bioorg Med Chem. 2010 Jun 15;18(12):4167-77. doi: 10.1016/j.bmc.2010.05.024. Epub 2010 May 11.

PMID:
20537544
18.
19.

Recent progress in discovery and development of antimitotic agents.

Kiselyov A, Balakin KV, Tkachenko SE, Savchuk N, Ivachtchenko AV.

Anticancer Agents Med Chem. 2007 Mar;7(2):189-208. Review.

PMID:
17348827
20.

Mitotic kinesins: prospects for antimitotic drug discovery.

Bergnes G, Brejc K, Belmont L.

Curr Top Med Chem. 2005;5(2):127-45. Review.

PMID:
15853642
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