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Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

Murdoch H, Mackie S, Collins DM, Hill EV, Bolger GB, Klussmann E, Porteous DJ, Millar JK, Houslay MD.

J Neurosci. 2007 Aug 29;27(35):9513-24.


Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

Collins DM, Murdoch H, Dunlop AJ, Charych E, Baillie GS, Wang Q, Herberg FW, Brandon N, Prinz A, Houslay MD.

Cell Signal. 2008 Dec;20(12):2356-69. doi: 10.1016/j.cellsig.2008.09.017. Epub 2008 Oct 2.


PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

Cheung YF, Kan Z, Garrett-Engele P, Gall I, Murdoch H, Baillie GS, Camargo LM, Johnson JM, Houslay MD, Castle JC.

J Pharmacol Exp Ther. 2007 Aug;322(2):600-9. Epub 2007 May 22.


DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.

Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ.

Science. 2005 Nov 18;310(5751):1187-91.


Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.

Millar JK, Mackie S, Clapcote SJ, Murdoch H, Pickard BS, Christie S, Muir WJ, Blackwood DH, Roder JC, Houslay MD, Porteous DJ.

J Physiol. 2007 Oct 15;584(Pt 2):401-5. Epub 2007 Sep 6. Review.


Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).

MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD.

Br J Pharmacol. 2002 Jun;136(3):421-33.


The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.

Smith PG, Wang F, Wilkinson KN, Savage KJ, Klein U, Neuberg DS, Bollag G, Shipp MA, Aguiar RC.

Blood. 2005 Jan 1;105(1):308-16. Epub 2004 Aug 26.


Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

Sheppard CL, Lee LC, Hill EV, Henderson DJ, Anthony DF, Houslay DM, Yalla KC, Cairns LS, Dunlop AJ, Baillie GS, Huston E, Houslay MD.

Cell Signal. 2014 Sep;26(9):1958-74. doi: 10.1016/j.cellsig.2014.04.023. Epub 2014 May 9.


Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors.

Saldou N, Obernolte R, Huber A, Baecker PA, Wilhelm R, Alvarez R, Li B, Xia L, Callan O, Su C, Jarnagin K, Shelton ER.

Cell Signal. 1998 Jun;10(6):427-40.


Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.

Shepherd M, McSorley T, Olsen AE, Johnston LA, Thomson NC, Baillie GS, Houslay MD, Bolger GB.

Biochem J. 2003 Mar 1;370(Pt 2):429-38.


Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.

Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD.

J Biol Chem. 2003 Aug 29;278(35):33351-63. Epub 2003 Jun 16.


Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

Huston E, Lumb S, Russell A, Catterall C, Ross AH, Steele MR, Bolger GB, Perry MJ, Owens RJ, Houslay MD.

Biochem J. 1997 Dec 1;328 ( Pt 2):549-58.


DISC1, PDE4B, and NDE1 at the centrosome and synapse.

Bradshaw NJ, Ogawa F, Antolin-Fontes B, Chubb JE, Carlyle BC, Christie S, Claessens A, Porteous DJ, Millar JK.

Biochem Biophys Res Commun. 2008 Dec 26;377(4):1091-6. doi: 10.1016/j.bbrc.2008.10.120. Epub 2008 Nov 5. Erratum in: Biochem Biophys Res Commun. 2009 Jul 3;384(3):400.


Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.

Millen J, MacLean MR, Houslay MD.

Eur J Cell Biol. 2006 Jul;85(7):679-91. Epub 2006 Feb 3.


Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses.

Sawamura N, Sawa A.

Ann N Y Acad Sci. 2006 Nov;1086:126-33. Review.

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