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Items: 1 to 20 of 92

1.

Utrophin up-regulation by an artificial transcription factor in transgenic mice.

Mattei E, Corbi N, Di Certo MG, Strimpakos G, Severini C, Onori A, Desantis A, Libri V, Buontempo S, Floridi A, Fanciulli M, Baban D, Davies KE, Passananti C.

PLoS One. 2007 Aug 22;2(8):e774.

2.

Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene.

Passananti C, Corbi N, Onori A, Di Certo MG, Mattei E.

Methods Mol Biol. 2010;649:183-206. doi: 10.1007/978-1-60761-753-2_11.

PMID:
20680835
3.

Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.

Strimpakos G, Corbi N, Pisani C, Di Certo MG, Onori A, Luvisetto S, Severini C, Gabanella F, Monaco L, Mattei E, Passananti C.

J Cell Physiol. 2014 Sep;229(9):1283-91. doi: 10.1002/jcp.24567.

4.

UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.

Onori A, Pisani C, Strimpakos G, Monaco L, Mattei E, Passananti C, Corbi N.

BMC Mol Biol. 2013 Jan 30;14:3. doi: 10.1186/1471-2199-14-3.

5.

The artificial gene Jazz, a transcriptional regulator of utrophin, corrects the dystrophic pathology in mdx mice.

Di Certo MG, Corbi N, Strimpakos G, Onori A, Luvisetto S, Severini C, Guglielmotti A, Batassa EM, Pisani C, Floridi A, Benassi B, Fanciulli M, Magrelli A, Mattei E, Passananti C.

Hum Mol Genet. 2010 Mar 1;19(5):752-60. doi: 10.1093/hmg/ddp539. Epub 2009 Dec 4.

6.

Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation.

Desantis A, Onori A, Di Certo MG, Mattei E, Fanciulli M, Passananti C, Corbi N.

Neuromuscul Disord. 2009 Feb;19(2):158-62. doi: 10.1016/j.nmd.2008.11.005. Epub 2009 Jan 21.

PMID:
19162479
7.

The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription.

Corbi N, Libri V, Fanciulli M, Tinsley JM, Davies KE, Passananti C.

Gene Ther. 2000 Jun;7(12):1076-83.

8.

The artificial 4-zinc-finger protein Bagly binds human utrophin promoter A at the endogenous chromosomal site and activates transcription.

Onori A, Desantis A, Buontempo S, Di Certo MG, Fanciulli M, Salvatori L, Passananti C, Corbi N.

Biochem Cell Biol. 2007 Jun;85(3):358-65.

PMID:
17612630
9.

Targeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function.

Lu Y, Tian C, Danialou G, Gilbert R, Petrof BJ, Karpati G, Nalbantoglu J.

J Biol Chem. 2008 Dec 12;283(50):34720-7. doi: 10.1074/jbc.M804518200. Epub 2008 Oct 21.

10.

Utrophin upregulation in Duchenne muscular dystrophy.

Hirst RC, McCullagh KJ, Davies KE.

Acta Myol. 2005 Dec;24(3):209-16. Review.

PMID:
16629055
11.

Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle.

Tanihata J, Suzuki N, Miyagoe-Suzuki Y, Imaizumi K, Takeda S.

J Gene Med. 2008 Jun;10(6):702-13. doi: 10.1002/jgm.1190.

PMID:
18338831
12.

The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine.

Takahashi J, Itoh Y, Fujimori K, Imamura M, Wakayama Y, Miyagoe-Suzuki Y, Takeda S.

J Gene Med. 2005 Feb;7(2):237-48.

PMID:
15538725
14.

Generation and characterization of transgenic mice with the full-length human DMD gene.

't Hoen PA, de Meijer EJ, Boer JM, Vossen RH, Turk R, Maatman RG, Davies KE, van Ommen GJ, van Deutekom JC, den Dunnen JT.

J Biol Chem. 2008 Feb 29;283(9):5899-907. Epub 2007 Dec 13.

15.

Utrophin upregulation for treating Duchenne or Becker muscular dystrophy: how close are we?

Miura P, Jasmin BJ.

Trends Mol Med. 2006 Mar;12(3):122-9. Epub 2006 Jan 27. Review.

PMID:
16443393
16.

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice.

Albesa M, Ogrodnik J, Rougier JS, Abriel H.

Cardiovasc Res. 2011 Feb 1;89(2):320-8. doi: 10.1093/cvr/cvq326. Epub 2010 Oct 14.

17.

Functional substitution by TAT-utrophin in dystrophin-deficient mice.

Sonnemann KJ, Heun-Johnson H, Turner AJ, Baltgalvis KA, Lowe DA, Ervasti JM.

PLoS Med. 2009 May 26;6(5):e1000083. doi: 10.1371/journal.pmed.1000083. Epub 2009 May 26.

18.

Microarray analysis of mdx mice expressing high levels of utrophin: therapeutic implications for dystrophin deficiency.

Baban D, Davies KE.

Neuromuscul Disord. 2008 Mar;18(3):239-47. doi: 10.1016/j.nmd.2007.11.011. Epub 2008 Mar 14.

PMID:
18343112
19.

Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.

Jasmin BJ, Angus LM, BĂ©langer G, Chakkalakal JV, Gramolini AO, Lunde JA, Stocksley MA, Thompson J.

J Physiol Paris. 2002 Jan-Mar;96(1-2):31-42. Review.

PMID:
11755781
20.

Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles.

Baker PE, Kearney JA, Gong B, Merriam AP, Kuhn DE, Porter JD, Rafael-Fortney JA.

Neurogenetics. 2006 May;7(2):81-91. Epub 2006 Mar 9.

PMID:
16525850
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