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17699108,12727841,16397018,16510571,11960372,16951221,17875724,14673954,17533050,16061651,10728680,12438264,15958548,15280448,12037677,16407846,16081048,17383969,18163422,17054436,15176047,19926637,23391762,16007122,11809683,15264241,12355449,15486993,17471507,16099994,19147545,17634147,15805299,16107692,17203201,16877361,14647442,18988190,16149059,17920763,19558577,19035205,17169602,17615260,22252296,18024479,20371673,16331276,16205632,17258390,17374439,19476491,20332458,19616846,15374974,15860735,18974106,16540637,15466183,18242580,18411043,16061629,19503092,18056453,18775869,16834928,17572495,11987152,15224348,16696944,19824884,16800851,14737107,16624747,16998813,11023821,19565565,10537273,20171193,16732314,16377083,16027730,19934272,17459060,15077160,17452977,16545852,18331685,16585216,18302613,15994924,21689417,15754128,16236134,15077188,17283176,16708798,15116091,20237834,16636663,11222745,17332277,14712222,17129668,16641140,19995546,16281503,10690529,16797880,24127753,16840717,17099727,16540670,16285960,20693278,16819511,15377837,17676033,17237818,16257052,19151334,16857804,17309823,21815198,15448191,16264989,19758315,17435608,16805833,19118003,11753675,17234541,20546860,21410405,11370821,17295906,17645497,11987157,17027757,16832345,20121258,20233902,16912181,15755760,16084091,23149124,21109950,19329556,11757799,11836576,22271514,15313471,17471161,16585165,22133921,17487394,20113836,19935868,17161614,15808070,23158658,23333300,8406563,16860716,23416296,15527761,15986140,16452193,20843232,17030178,16231698,15936715,15735721,25896132,17471234,17608645,17341611,17661355,27732936,26212545,16401721,16516862,15324743,16474387,16127698,19372587,15979198,23329648,17583567,21617523,16904607,17610223,20516148,17241516,17364491,10617865,17477370,17118707,17510282,7812736,16790289,15971270,24491388,16517055,18939993,15389819,25401333,16612594,16634641,27938379,23583378,2704881,17214367,17090229,26046794,24913037,21873055,15307194,17143562,24658061,16406094,16728275,16044165,16736599,18198175,23917203,16800735,14566335,15378007,24067369,21937440,21063201,20830236,20828571,15138572,29449694,16427042,19491198,32064600,16715304,16207253,17634277,22841220,16567971,16482776,23677069,17377598,18353781,17094106,20215508,16890388,26559373,15781862,17403142,15839894,21030257,25111868,22046235,21697955,15289316,20181527,26549437,24740453,24486192,16713356,16831436,16804520,25231320,23288901,15245366,21538419,34376733,7410488,10455410,22130933,20929579,17214706,16729994,19345327,21502401,27248826,21102457,22528488,17922140,19903771,17572509,16541098,16632122,22750444,21622714,21868636,17344214,19070595,10188223,19427337,23416975,28608828,18782771,10408382,28545024,18576943,28467474,16106057,17137635,19474327,858919,27076684,15781265,23750211,31500219,8085842,25139989,17875688,17572059,25825152,28642132,19074878,15870424,16530087,16797369,27435207,34465361,19601811,18566225,19484134,26984284,19437535,25432365,31765941,23967200,24483027,29456111,23066027,16948860,25968456,21325207,22140473,24667374,20930550,20169197,28765327,25633035,29914167,17202361,26478441,16323243,23716595,17426052,16407171,21084727,17438134,18930029,31013746,30231553,7461708,29875329,15943774,22279540,18948436,18403020,11912448,20388875,27861797,16082218,15009429,15350899,27453253,21094641,33278500,16956893,26384563,24755219,21568920,24191246,24455684,17175261,26688068,24760274,24550541,35871131,35042959,31936807,25733697,27542280,16076816,19282476,22402588,27103329,1120309,24142927,10556815,16200405,19723879,26662504,15686596,28489571,15276914,29222039,29212252,28390315,22075167,16552073,24487064,17113993,16094633,26649644,32219156,25436678,30987235,4164027,34953855,35722967,18065416,20807804,5813967,31451218,35752777,26512722,31218960,29765537,26260883,30817315,34376200,21493888,5394186,36066963,33747356,31201166,32967366,29101395,17509878,18479894,34239543,26000098,7419286,30590044,35052426,20814592,24743778,33413624,35810312,12616723,13498468,32733808,16320602,13749695,13739917,13671048,13201755,13502557,13574701,13620915,13727136,14038991,13398627,31328019,13651284,37079573,13712203,13704934,36318620,13577324,31907421,22190379,29144494[uid]

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Activated signal transducers and activators of transcription 3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity.

Buettner R, Huang M, Gritsko T, Karras J, Enkemann S, Mesa T, Nam S, Yu H, Jove R. Buettner R, et al. Mol Cancer Res. 2007 Aug;5(8):823-32. doi: 10.1158/1541-7786.MCR-06-0352. Mol Cancer Res. 2007. PMID: 17699108

Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.

Zerbini LF, Wang Y, Cho JY, Libermann TA. Zerbini LF, et al. Cancer Res. 2003 May 1;63(9):2206-15. Cancer Res. 2003. PMID: 12727841

Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells.

Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R. Gritsko T, et al. Clin Cancer Res. 2006 Jan 1;12(1):11-9. doi: 10.1158/1078-0432.CCR-04-1752. Clin Cancer Res. 2006. PMID: 16397018

Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.

Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, Sakamaki T, Pestell R, Bromberg J. Leslie K, et al. Cancer Res. 2006 Mar 1;66(5):2544-52. doi: 10.1158/0008-5472.CAN-05-2203. Cancer Res. 2006. PMID: 16510571

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H. Niu G, et al. Oncogene. 2002 Mar 27;21(13):2000-8. doi: 10.1038/sj.onc.1205260. Oncogene. 2002. PMID: 11960372

Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer.

Duan Z, Foster R, Bell DA, Mahoney J, Wolak K, Vaidya A, Hampel C, Lee H, Seiden MV. Duan Z, et al. Clin Cancer Res. 2006 Sep 1;12(17):5055-63. doi: 10.1158/1078-0432.CCR-06-0861. Clin Cancer Res. 2006. PMID: 16951221

Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.

Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD, Wilding G, Verma AK. Aziz MH, et al. Cancer Res. 2007 Sep 15;67(18):8828-38. doi: 10.1158/0008-5472.CAN-07-1604. Cancer Res. 2007. PMID: 17875724

Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line.

Udayakumar TS, Nagle RB, Bowden GT. Udayakumar TS, et al. Prostate. 2004 Jan 1;58(1):66-75. doi: 10.1002/pros.10293. Prostate. 2004. PMID: 14673954

Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines.

Gu L, Chiang KY, Zhu N, Findley HW, Zhou M. Gu L, et al. Exp Hematol. 2007 Jun;35(6):957-66. doi: 10.1016/j.exphem.2007.03.007. Exp Hematol. 2007. PMID: 17533050 Clinical Trial.

A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.

Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC Jr, Luo RZ. Nishimoto A, et al. Cancer Res. 2005 Aug 1;65(15):6701-10. doi: 10.1158/0008-5472.CAN-05-0130. Cancer Res. 2005. PMID: 16061651

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