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Results: 1 to 20 of 375

1.

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.

Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH.

J Clin Invest. 2007 Aug;117(8):2250-9.

PMID:
17627302
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.

Hato T, Yamanouchi J, Tamura T, Yakushijin Y, Sakai I, Yasukawa M.

J Biol Chem. 2008 Feb 29;283(9):5662-8. doi: 10.1074/jbc.M707246200. Epub 2008 Jan 2.

PMID:
18174155
[PubMed - indexed for MEDLINE]
Free Article
3.

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH.

J Exp Med. 2007 Dec 24;204(13):3103-11. Epub 2007 Dec 17.

PMID:
18086863
[PubMed - indexed for MEDLINE]
Free PMC Article
4.
5.

A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.

Tremuth L, Kreis S, Melchior C, Hoebeke J, Rondé P, Plançon S, Takeda K, Kieffer N.

J Biol Chem. 2004 May 21;279(21):22258-66. Epub 2004 Mar 18.

PMID:
15031296
[PubMed - indexed for MEDLINE]
Free Article
6.

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3.

Naik MU, Nigam A, Manrai P, Millili P, Czymmek K, Sullivan M, Naik UP.

J Thromb Haemost. 2009 Nov;7(11):1906-14. doi: 10.1111/j.1538-7836.2009.03581.x. Epub 2009 Aug 19.

PMID:
19691476
[PubMed - indexed for MEDLINE]
7.

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

Schwarz M, Meade G, Stoll P, Ylanne J, Bassler N, Chen YC, Hagemeyer CE, Ahrens I, Moran N, Kenny D, Fitzgerald D, Bode C, Peter K.

Circ Res. 2006 Jul 7;99(1):25-33. Epub 2006 Jun 15.

PMID:
16778135
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibition of platelet activation by peptide analogs of the beta(3)-intracellular domain of platelet integrin alpha(IIb)beta(3) conjugated to the cell-penetrating peptide Tat(48-60).

Dimitriou AA, Stathopoulos P, Mitsios JV, Sakarellos-Daitsiotis M, Goudevenos J, Tsikaris V, Tselepis AD.

Platelets. 2009 Dec;20(8):539-47. doi: 10.3109/09537100903324219.

PMID:
19863457
[PubMed - indexed for MEDLINE]
9.

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.

Stefanini L, Ye F, Snider AK, Sarabakhsh K, Piatt R, Paul DS, Bergmeier W, Petrich BG.

Blood. 2014 Apr 24;123(17):2722-31. doi: 10.1182/blood-2013-12-543363. Epub 2014 Feb 28.

PMID:
24585775
[PubMed - indexed for MEDLINE]
10.

The molecular basis of filamin binding to integrins and competition with talin.

Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA.

Mol Cell. 2006 Feb 3;21(3):337-47.

PMID:
16455489
[PubMed - indexed for MEDLINE]
Free Article
11.

Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.

Holmbäck K, Danton MJ, Suh TT, Daugherty CC, Degen JL.

EMBO J. 1996 Nov 1;15(21):5760-71.

PMID:
8918453
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation.

Campus F, Lova P, Bertoni A, Sinigaglia F, Balduini C, Torti M.

J Biol Chem. 2005 Jul 1;280(26):24386-95. Epub 2005 Apr 29.

PMID:
15863506
[PubMed - indexed for MEDLINE]
Free Article
13.

Adhesion-induced unclasping of cytoplasmic tails of integrin alpha(IIb)beta3.

Podolnikova NP, O'Toole TE, Haas TA, Lam SC, Fox JE, Ugarova TP.

Biochemistry. 2009 Jan 27;48(3):617-29. doi: 10.1021/bi801751s.

PMID:
19117493
[PubMed - indexed for MEDLINE]
14.

Calcium integrin-binding protein activates platelet integrin alpha IIbbeta 3.

Tsuboi S.

J Biol Chem. 2002 Jan 18;277(3):1919-23. Epub 2001 Nov 9.

PMID:
11704681
[PubMed - indexed for MEDLINE]
Free Article
15.

Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3).

Biris N, Abatzis M, Mitsios JV, Sakarellos-Daitsiotis M, Sakarellos C, Tsoukatos D, Tselepis AD, Michalis L, Sideris D, Konidou G, Soteriadou K, Tsikaris V.

Eur J Biochem. 2003 Sep;270(18):3760-7.

PMID:
12950259
[PubMed - indexed for MEDLINE]
Free Article
16.

CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.

Yuan W, Leisner TM, McFadden AW, Wang Z, Larson MK, Clark S, Boudignon-Proudhon C, Lam SC, Parise LV.

J Cell Biol. 2006 Jan 16;172(2):169-75.

PMID:
16418530
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Platelet integrin alpha(IIb)beta(3): activation mechanisms.

Ma YQ, Qin J, Plow EF.

J Thromb Haemost. 2007 Jul;5(7):1345-52. Review.

PMID:
17635696
[PubMed - indexed for MEDLINE]
18.

Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif.

Reilly D, Larkin D, Devocelle M, Fitzgerald DJ, Moran N.

Platelets. 2004 Feb;15(1):43-54.

PMID:
14985176
[PubMed - indexed for MEDLINE]
19.

Structural basis of integrin activation by talin.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID.

Cell. 2007 Jan 12;128(1):171-82.

PMID:
17218263
[PubMed - indexed for MEDLINE]
Free Article

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