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Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.

Qi L, Zhang C, van Dam RM, Hu FB.

J Clin Endocrinol Metab. 2007 Sep;92(9):3618-25. Epub 2007 Jul 10. Review.


Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis.

Qi L, van Dam RM, Meigs JB, Manson JE, Hunter D, Hu FB.

Hum Mol Genet. 2006 Jun 1;15(11):1914-20. Epub 2006 Apr 27.


Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.

Slattery ML, Curtin K, Sweeney C, Wolff RK, Baumgartner RN, Baumgartner KB, Giuliano AR, Byers T.

Obesity (Silver Spring). 2008 Feb;16(2):339-47. doi: 10.1038/oby.2007.44.


Polymorphisms in the neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts.

Yeung EH, Zhang C, Chen J, Bowers K, Hu FB, Kang G, Qi L.

J Clin Endocrinol Metab. 2011 Dec;96(12):E2055-62. doi: 10.1210/jc.2011-0195. Epub 2011 Sep 21.


A variant near the interleukin-6 gene is associated with fat mass in Caucasian men.

Andersson N, Strandberg L, Nilsson S, Adamovic S, Karlsson MK, Ljunggren O, Mellström D, Lane NE, Zmuda JM, Nielsen C, Orwoll E, Lorentzon M, Ohlsson C, Jansson JO; Osteoporotic Fractures in Men MrOS Research Group.

Int J Obes (Lond). 2010 Jun;34(6):1011-9. doi: 10.1038/ijo.2010.27. Epub 2010 Feb 16.


IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden.

Strandberg L, Mellström D, Ljunggren O, Grundberg E, Karlsson MK, Holmberg AH, Orwoll ES, Eriksson AL, Svedberg J, Bengtsson M, Ohlsson C, Jansson JO.

Obesity (Silver Spring). 2008 Mar;16(3):710-3. doi: 10.1038/oby.2007.95. Epub 2008 Jan 17.


A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change.

Razquin C, Martinez JA, Martinez-Gonzalez MA, Fernández-Crehuet J, Santos JM, Marti A.

Mol Nutr Food Res. 2010 May;54 Suppl 1:S75-82. doi: 10.1002/mnfr.200900257.


The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls.

Dema B, Martínez A, Fernández-Arquero M, Maluenda C, Polanco I, Figueredo MA, de la Concha EG, Urcelay E, Núñez C.

Hum Immunol. 2009 Mar;70(3):191-4.


Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery.

Poitou C, Lacorte JM, Coupaye M, Bertrais S, Bedel JF, Lafon N, Bouillot JL, Galan P, Borson-Chazot F, Basdevant A, Coussieu C, Clément K.

Obes Surg. 2005 Jan;15(1):11-23.


Body composition changes after laparoscopic adjustable gastric banding: what is the role of -174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

Di Renzo L, Carbonelli MG, Bianchi A, Iacopino L, Fiorito R, Di Daniele N, De Lorenzo A.

Int J Obes (Lond). 2012 Mar;36(3):369-78. doi: 10.1038/ijo.2011.132. Epub 2011 Jul 5.


Abdominal and total adiposity and risk of coronary heart disease in men.

Rexrode KM, Buring JE, Manson JE.

Int J Obes Relat Metab Disord. 2001 Jul;25(7):1047-56.


Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Huth C, Illig T, Herder C, Gieger C, Grallert H, Vollmert C, Rathmann W, Hamid YH, Pedersen O, Hansen T, Thorand B, Meisinger C, Doring A, Klopp N, Gohlke H, Lieb W, Hengstenberg C, Lyssenko V, Groop L, Ireland H, Stephens JW, Wernstedt Asterholm I, Jansson JO, Boeing H, Mohlig M, Stringham HM, Boehnke M, Tuomilehto J, Fernandez-Real JM, Lopez-Bermejo A, Gallart L, Vendrell J, Humphries SE, Kronenberg F, Wichmann HE, Heid IM.

Ann Med. 2009;41(2):128-38. doi: 10.1080/07853890802337037.


A variant in the LRRFIP1 gene is associated with adiposity and inflammation.

Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L.

Obesity (Silver Spring). 2013 Jan;21(1):185-92. doi: 10.1002/oby.20242.


Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study.

Wei Q, Jacobs DR Jr, Schreiner PJ, Siscovick DS, Steffes MW, Fornage M.

J Mol Med (Berl). 2006 Nov;84(11):955-65. Epub 2006 Sep 6.


Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.

Talbert ME, Langefeld CD, Ziegler J, Mychaleckyj JC, Haffner SM, Norris JM, Bowden DW.

Hum Genet. 2009 Mar;125(2):153-62. doi: 10.1007/s00439-008-0608-3. Epub 2008 Dec 13.


Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study.

Klipstein-Grobusch K, Möhlig M, Spranger J, Hoffmann K, Rodrigues FU, Sharma AM, Klaus S, Pfeiffer AF, Boeing H.

Obesity (Silver Spring). 2006 Jan;14(1):14-8.


Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Suchiman HE, Jacobsen R, McGue M, Stevnsner T, Bohr VA, de Craen AJ, Westendorp RG, Schreiber S, Slagboom PE, Nebel A, Vaupel JW, Christensen K, Christiansen L.

Age (Dordr). 2013 Apr;35(2):487-500. doi: 10.1007/s11357-011-9373-7. Epub 2012 Jan 12.


Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia.

Zakharyan R, Petrek M, Arakelyan A, Mrazek F, Atshemyan S, Boyajyan A.

Tissue Antigens. 2012 Aug;80(2):136-42. doi: 10.1111/j.1399-0039.2012.01886.x. Epub 2012 May 10.


Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals.

Oliveira Rd, Cerda A, Genvigir FD, Sampaio MF, Armaganijan D, Bernik MM, Dorea EL, Hirata MH, Hinuy HM, Hirata RD.

Arq Bras Endocrinol Metabol. 2013 Dec;57(9):677-84.


C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.

Cardellini M, Perego L, D'Adamo M, Marini MA, Procopio C, Hribal ML, Andreozzi F, Frontoni S, Giacomelli M, Paganelli M, Pontiroli AE, Lauro R, Folli F, Sesti G.

Diabetes Care. 2005 Aug;28(8):2007-12.

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