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Items: 1 to 20 of 117

1.

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO.

Nature. 2007 Jul 26;448(7152):470-3. Epub 2007 Jul 4.

PMID:
17611496
2.

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.

Schedel M, Michel S, Gaertner VD, Toncheva AA, Depner M, Binia A, Schieck M, Rieger MT, Klopp N, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Genuneit J, Illig T, Kabesch M.

J Allergy Clin Immunol. 2015 Oct;136(4):893-903.e14. doi: 10.1016/j.jaci.2015.03.014. Epub 2015 Apr 28.

PMID:
25930191
3.

Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study.

Yu X, Yu C, Ren Z, Deng Y, Song J, Zhang H, Zhou H.

Tissue Antigens. 2014 May;83(5):330-6. doi: 10.1111/tan.12342. Epub 2014 Mar 21.

PMID:
24649901
4.

Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.

Fang Q, Zhao H, Wang A, Gong Y, Liu Q.

BMC Med Genet. 2011 Oct 11;12:133. doi: 10.1186/1471-2350-12-133.

5.

A sequence variant on 17q21 is associated with age at onset and severity of asthma.

Halapi E, Gudbjartsson DF, Jonsdottir GM, Bjornsdottir US, Thorleifsson G, Helgadottir H, Williams C, Koppelman GH, Heinzmann A, Boezen HM, Jonasdottir A, Blondal T, Gudjonsson SA, Jonasdottir A, Thorlacius T, Henry AP, Altmueller J, Krueger M, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Ludviksson BR, Ludviksdottir D, Gislason D, Park CS, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K.

Eur J Hum Genet. 2010 Aug;18(8):902-8. doi: 10.1038/ejhg.2010.38. Epub 2010 Apr 7.

6.

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion.

Lluis A, Schedel M, Liu J, Illi S, Depner M, von Mutius E, Kabesch M, Schaub B.

J Allergy Clin Immunol. 2011 Jun;127(6):1587-94.e6. doi: 10.1016/j.jaci.2011.03.015. Epub 2011 May 4.

PMID:
21546069
7.

Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.

Ferreira MA, McRae AF, Medland SE, Nyholt DR, Gordon SD, Wright MJ, Henders AK, Madden PA, Visscher PM, Wray NR, Heath AC, Montgomery GW, Duffy DL, Martin NG.

Eur J Hum Genet. 2011 Apr;19(4):458-64. doi: 10.1038/ejhg.2010.191. Epub 2010 Dec 8. Erratum in: Eur J Hum Genet. 2011 Oct;19(10):1109.

8.

Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population.

Tomita K, Sakashita M, Hirota T, Tanaka S, Masuyama K, Yamada T, Fujieda S, Miyatake A, Hizawa N, Kubo M, Nakamura Y, Tamari M.

Allergy. 2013 Jan;68(1):92-100. doi: 10.1111/all.12066. Epub 2012 Nov 12.

9.

Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.

Leung TF, Sy HY, Ng MC, Chan IH, Wong GW, Tang NL, Waye MM, Lam CW.

Allergy. 2009 Apr;64(4):621-8. doi: 10.1111/j.1398-9995.2008.01873.x. Epub 2009 Jan 27.

10.

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.

Berce V, Kozmus CE, Potočnik U.

Pharmacogenomics J. 2013 Dec;13(6):523-9. doi: 10.1038/tpj.2012.36. Epub 2012 Sep 18.

PMID:
22986918
11.

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.

Acevedo N, Reinius LE, Greco D, Gref A, Orsmark-Pietras C, Persson H, Pershagen G, Hedlin G, Melén E, Scheynius A, Kere J, Söderhäll C.

Hum Mol Genet. 2015 Feb 1;24(3):875-90. doi: 10.1093/hmg/ddu479. Epub 2014 Sep 25.

12.

Effect of 17q21 variants and smoking exposure in early-onset asthma.

Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J, Chateigner N, Gormand F, Just J, Le Moual N, Scheinmann P, Siroux V, Vervloet D, Zelenika D, Pin I, Kauffmann F, Lathrop M, Demenais F.

N Engl J Med. 2008 Nov 6;359(19):1985-94. doi: 10.1056/NEJMoa0806604. Epub 2008 Oct 15.

13.

Relationship between the 17q21 locus and adult asthma in a Czech population.

Hrdlickova B, Holla LI.

Hum Immunol. 2011 Oct;72(10):921-5. doi: 10.1016/j.humimm.2011.07.309. Epub 2011 Aug 1.

PMID:
21843571
14.

17q21 variants modify the association between early respiratory infections and asthma.

Smit LA, Bouzigon E, Pin I, Siroux V, Monier F, Aschard H, Bousquet J, Gormand F, Just J, Le Moual N, Nadif R, Scheinmann P, Vervloet D, Lathrop M, Demenais F, Kauffmann F; EGEA Cooperative Group.

Eur Respir J. 2010 Jul;36(1):57-64. doi: 10.1183/09031936.00154509. Epub 2009 Dec 23.

15.

Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.

Granell R, Henderson AJ, Timpson N, St Pourcain B, Kemp JP, Ring SM, Ho K, Montgomery SB, Dermitzakis ET, Evans DM, Sterne JA.

J Allergy Clin Immunol. 2013 Mar;131(3):685-94. doi: 10.1016/j.jaci.2012.09.021. Epub 2012 Nov 13.

16.

[Genome-wide association study of bronchial asthma in the Volga-Ural region of Russia].

Karunas AS, Iunusbaev BB, Fedorova IuIu, Gimalova GF, Ramazanova NN, Gur'eva LL, Mukhtarova LA, Zagidullin ShZ, Etkina EI, Khusnutdinova EK.

Mol Biol (Mosk). 2011 Nov-Dec;45(6):992-1003. Russian.

PMID:
22295569
17.

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Larivière M, Moussette S, Grundberg E, Kwan T, Ouimet M, Ge B, Hoberman R, Swiatek M, Dias J, Lam KC, Koka V, Harmsen E, Soto-Quiros M, Avila L, Celedón JC, Weiss ST, Dewar K, Sinnett D, Laprise C, Raby BA, Pastinen T, Naumova AK.

Am J Hum Genet. 2009 Sep;85(3):377-93. doi: 10.1016/j.ajhg.2009.08.007.

18.

Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.

Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, London SJ.

Allergy. 2009 Apr;64(4):629-35. doi: 10.1111/j.1398-9995.2008.01912.x. Epub 2008 Dec 30.

19.

Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.

Toncheva AA, Potaczek DP, Schedel M, Gersting SW, Michel S, Krajnov N, Gaertner VD, Klingbeil JM, Illig T, Franke A, Winkler C, Hohlfeld JM, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Muntau AC, Kabesch M.

Allergy. 2015 Oct;70(10):1288-99. doi: 10.1111/all.12652. Epub 2015 Jul 20.

PMID:
26011647
20.

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.

Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN.

J Allergy Clin Immunol. 2008 Apr;121(4):860-3. doi: 10.1016/j.jaci.2008.01.015.

PMID:
18395550
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