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Items: 1 to 20 of 83

1.

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.

Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES.

Cell Death Differ. 2007 Sep;14(9):1590-604. Epub 2007 Jun 29.

2.

Assembly, purification, and assay of the activity of the ASC pyroptosome.

Fernandes-Alnemri T, Alnemri ES.

Methods Enzymol. 2008;442:251-70. doi: 10.1016/S0076-6879(08)01413-4.

PMID:
18662574
3.

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.

Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES.

Mol Cell. 2007 Oct 26;28(2):214-27.

4.

Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.

Stehlik C, Lee SH, Dorfleutner A, Stassinopoulos A, Sagara J, Reed JC.

J Immunol. 2003 Dec 1;171(11):6154-63.

5.

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

Pierini R, Juruj C, Perret M, Jones CL, Mangeot P, Weiss DS, Henry T.

Cell Death Differ. 2012 Oct;19(10):1709-21. doi: 10.1038/cdd.2012.51. Epub 2012 May 4.

6.

Cryopyrin activates the inflammasome in response to toxins and ATP.

Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM.

Nature. 2006 Mar 9;440(7081):228-32. Epub 2006 Jan 11.

PMID:
16407890
7.

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES.

Nature. 2009 Mar 26;458(7237):509-13. doi: 10.1038/nature07710. Epub 2009 Jan 21.

8.

PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC.

J Biol Chem. 2004 Dec 10;279(50):51897-907. Epub 2004 Sep 28.

9.

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms.

Fink SL, Bergsbaken T, Cookson BT.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4312-7. doi: 10.1073/pnas.0707370105. Epub 2008 Mar 12.

10.

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB.

PLoS Pathog. 2011 Apr;7(4):e1002026. doi: 10.1371/journal.ppat.1002026. Epub 2011 Apr 21.

11.

Regulating caspase-1 during infection: roles of NLRs, AIM2, and ASC.

Case CL.

Yale J Biol Med. 2011 Dec;84(4):333-43. Review.

12.

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nuñez G.

PLoS Pathog. 2007 Aug 10;3(8):e111.

13.

Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division.

Stein R, Kapplusch F, Heymann MC, Russ S, Staroske W, Hedrich CM, Rösen-Wolff A, Hofmann SR.

J Biol Chem. 2016 Jul 8. pii: jbc.M116.718668. [Epub ahead of print]

14.

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.

Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes L.

Cell Death Dis. 2015 Jul 9;6:e1813. doi: 10.1038/cddis.2015.186.

15.

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ.

Cell Death Differ. 2013 Sep;20(9):1149-60. doi: 10.1038/cdd.2013.37. Epub 2013 May 3.

16.

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.

Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES.

J Biol Chem. 2002 Jun 14;277(24):21119-22. Epub 2002 Apr 19.

17.

ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome.

Mariathasan S.

Microbes Infect. 2007 Apr;9(5):664-71. Epub 2007 Jan 27. Review.

PMID:
17382568
18.

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

Kahlenberg JM, Dubyak GR.

Am J Physiol Cell Physiol. 2004 May;286(5):C1100-8. Epub 2003 Dec 24.

19.

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6. doi: 10.1073/pnas.1211521110. Epub 2013 Jan 10.

20.
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