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Items: 1 to 20 of 70

1.

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X.

FASEB J. 2007 Oct;21(12):3023-8. Epub 2007 Jun 26. No abstract available.

3.

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.

Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S.

Hum Mol Genet. 2000 Jul 1;9(11):1681-90.

4.

Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.

Lin HY, Michtalik HJ, Zhang S, Andersen TT, Van Riper DA, Davies KK, Ermak G, Petti LM, Nachod S, Narayan AV, Bhatt N, Crawford DR.

Free Radic Biol Med. 2003 Sep 1;35(5):528-39.

PMID:
12927602
5.

Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease.

Harris CD, Ermak G, Davies KJ.

Cell Mol Life Sci. 2005 Nov;62(21):2477-86. Review.

PMID:
16231093
7.

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.

Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS.

J Biol Chem. 2000 Mar 24;275(12):8719-25.

8.

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S.

Nature. 2009 Jun 25;459(7250):1126-30. doi: 10.1038/nature08062. Epub 2009 May 20.

9.

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease.

Ermak G, Morgan TE, Davies KJ.

J Biol Chem. 2001 Oct 19;276(42):38787-94. Epub 2001 Aug 1.

10.

c-Jun inhibits thapsigargin-induced ER stress through up-regulation of DSCR1/Adapt78.

Zhao P, Xiao X, Kim AS, Leite MF, Xu J, Zhu X, Ren J, Li J.

Exp Biol Med (Maywood). 2008 Oct;233(10):1289-300. doi: 10.3181/0803-RM-84. Epub 2008 Jul 18.

PMID:
18641051
11.

Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates.

Lee EJ, Lee JY, Seo SR, Chung KC.

Mol Cell Neurosci. 2007 Aug;35(4):585-95. Epub 2007 May 18.

PMID:
17596961
12.

Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).

Kim SS, Oh Y, Chung KC, Seo SR.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):657-61. doi: 10.1016/j.bbrc.2012.01.071. Epub 2012 Jan 24.

PMID:
22293192
13.
14.

Raf-1 is a binding partner of DSCR1.

Cho YJ, Abe M, Kim SY, Sato Y.

Arch Biochem Biophys. 2005 Jul 1;439(1):121-8.

PMID:
15935327
15.

Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.

Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.

Mol Cancer Res. 2006 Nov;4(11):811-20.

16.

RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression.

Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M.

Biochim Biophys Acta. 2007 Mar;1773(3):330-41. Epub 2006 Dec 21.

17.

Association of metastin/a G-protein-coupled receptor signaling and Down syndrome critical region 1 in epithelial ovarian cancer.

Hata K, Watanabe Y, Nakai H, Minami T, Ohsaki H, Hirakawa E, Hoshiai H.

Anticancer Res. 2009 Feb;29(2):617-23.

18.

A conserved family of calcineurin regulators.

Kingsbury TJ, Cunningham KW.

Genes Dev. 2000 Jul 1;14(13):1595-604.

19.

Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin.

Lee JE, Jang H, Cho EJ, Youn HD.

Exp Mol Med. 2009 Jul 31;41(7):471-7. doi: 10.3858/emm.2009.41.7.052.

20.

Mutational analyses of the signals involved in the subcellular location of DSCR1.

Pfister SC, Machado-Santelli GM, Han SW, Henrique-Silva F.

BMC Cell Biol. 2002 Sep 11;3:24.

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