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Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.

Arudchandran A, Bernstein RM, Max EE.

Int Immunol. 2008 Nov;20(11):1381-93. doi: 10.1093/intimm/dxn097. Epub 2008 Sep 15.


Inducible DNA breaks in Ig S regions are dependent on AID and UNG.

Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J.

J Exp Med. 2005 Aug 15;202(4):561-8.


Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J.

J Immunol. 2007 Nov 1;179(9):6064-71. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T.

Science. 2004 Aug 20;305(5687):1160-3.


DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.

DNA Repair (Amst). 2013 Dec;12(12):1087-93. doi: 10.1016/j.dnarep.2013.09.002. Epub 2013 Sep 29.


Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.

Stavnezer J, Schrader CE.

Trends Genet. 2006 Jan;22(1):23-8. Epub 2005 Nov 23.


Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.

Zan H, Zhang J, Al-Qahtani A, Pone EJ, White CA, Lee D, Yel L, Mai T, Casali P.

Mol Immunol. 2011 Jan;48(4):610-22. doi: 10.1016/j.molimm.2010.10.023. Epub 2010 Nov 26.


AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J.

J Immunol. 2011 Sep 1;187(5):2464-75. doi: 10.4049/jimmunol.1101406. Epub 2011 Jul 29. Erratum in: J Immunol. 2014 May 15;192(10):4934.


Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies.

Durandy A, Taubenheim N, Peron S, Fischer A.

Adv Immunol. 2007;94:275-306. Review.


Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.

Begum NA, Stanlie A, Doi T, Sasaki Y, Jin HW, Kim YS, Nagaoka H, Honjo T.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2752-7. doi: 10.1073/pnas.0813252106. Epub 2009 Feb 6.


Immunoglobulin class switch recombination is impaired in Atm-deficient mice.

Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC 3rd, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ.

J Exp Med. 2004 Nov 1;200(9):1111-21. Epub 2004 Oct 25.


The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.

Schrader CE, Guikema JE, Wu X, Stavnezer J.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):645-52. doi: 10.1098/rstb.2008.0200. Review.


Internal IgH class switch region deletions are position-independent and enhanced by AID expression.

Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. Epub 2002 Jul 11.


Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW.

Science. 2007 Jan 19;315(5810):377-81. Epub 2006 Dec 14.


Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.

Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1016-24. doi: 10.1073/pnas.1402391111. Epub 2014 Mar 3.


Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.

Zan H, White CA, Thomas LM, Mai T, Li G, Xu Z, Zhang J, Casali P.

Cell Rep. 2012 Nov 29;2(5):1220-32. doi: 10.1016/j.celrep.2012.09.029. Epub 2012 Nov 8.


Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.

Begum NA, Izumi N, Nishikori M, Nagaoka H, Shinkura R, Honjo T.

J Biol Chem. 2007 Jan 5;282(1):731-42. Epub 2006 Nov 6.

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