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Results: 1 to 20 of 174

1.

Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.

Gauna C, Kiewiet RM, Janssen JA, van de Zande B, Delhanty PJ, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E697-704. Epub 2007 Jun 19.

PMID:
17578884
[PubMed - indexed for MEDLINE]
Free Article
2.

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.

Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E, van der Lely AJ.

Mol Cell Endocrinol. 2006 Jun 7;251(1-2):103-11. Epub 2006 Apr 27.

PMID:
16647196
[PubMed - indexed for MEDLINE]
3.

Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.

Gauna C, Uitterlinden P, Kramer P, Kiewiet RM, Janssen JA, Delhanty PJ, van Aken MO, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ.

Endocrinology. 2007 Nov;148(11):5278-87. Epub 2007 Aug 2.

PMID:
17673520
[PubMed - indexed for MEDLINE]
4.

Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat.

Kiewiet RM, Gauna C, van Aken MO, van de Zande B, van der Lely AJ.

Peptides. 2008 Dec;29(12):2144-9. doi: 10.1016/j.peptides.2008.09.011. Epub 2008 Sep 26.

PMID:
18930090
[PubMed - indexed for MEDLINE]
5.

Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, Van Der Lely AJ, Ghigo E.

J Clin Endocrinol Metab. 2004 Jun;89(6):3062-5.

PMID:
15181099
[PubMed - indexed for MEDLINE]
6.

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.

Kiewiet RM, van Aken MO, van der Weerd K, Uitterlinden P, Themmen AP, Hofland LJ, de Rijke YB, Delhanty PJ, Ghigo E, Abribat T, van der Lely AJ.

Eur J Endocrinol. 2009 Oct;161(4):567-73. doi: 10.1530/EJE-09-0339. Epub 2009 Jul 23.

PMID:
19628651
[PubMed - indexed for MEDLINE]
Free Article
7.

In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis.

Ni H, De Waele K, Walia P, Chanoine JP.

Pediatr Res. 2010 Jun;67(6):609-13. doi: 10.1203/PDR.0b013e3181da463a.

PMID:
20496472
[PubMed - indexed for MEDLINE]
8.

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.

Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T.

Diabetes. 2004 Dec;53(12):3142-51.

PMID:
15561944
[PubMed - indexed for MEDLINE]
Free Article
9.

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.

PMID:
17068144
[PubMed - indexed for MEDLINE]
10.

Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.

Delhanty PJ, van Koetsveld PM, Gauna C, van de Zande B, Vitale G, Hofland LJ, van der Lely AJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E302-9. Epub 2007 Apr 3.

PMID:
17405826
[PubMed - indexed for MEDLINE]
Free Article
11.

Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.

Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M.

J Mol Endocrinol. 2010 Jul;45(1):9-17. doi: 10.1677/JME-09-0141. Epub 2010 Apr 9.

PMID:
20382773
[PubMed - indexed for MEDLINE]
Free Article
12.

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes.

Gauna C, Delhanty PJ, Hofland LJ, Janssen JA, Broglio F, Ross RJ, Ghigo E, van der Lely AJ.

J Clin Endocrinol Metab. 2005 Feb;90(2):1055-60. Epub 2004 Nov 9.

PMID:
15536157
[PubMed - indexed for MEDLINE]
13.

Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice.

Salehi A, Dornonville de la Cour C, Håkanson R, Lundquist I.

Regul Pept. 2004 May 15;118(3):143-50.

PMID:
15003830
[PubMed - indexed for MEDLINE]
14.

Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.

Tong J, Davis HW, Summer S, Benoit SC, Haque A, Bidlingmaier M, Tschöp MH, D'Alessio D.

Diabetes. 2014 Jul;63(7):2309-19. doi: 10.2337/db13-1598. Epub 2014 Feb 18.

PMID:
24550190
[PubMed - indexed for MEDLINE]
15.

Unacylated as well as acylated ghrelin promotes cell survival and inhibit apoptosis in HIT-T15 pancreatic beta-cells.

Granata R, Settanni F, Trovato L, Destefanis S, Gallo D, Martinetti M, Ghigo E, Muccioli G.

J Endocrinol Invest. 2006 Oct;29(9):RC19-22.

PMID:
17114904
[PubMed - indexed for MEDLINE]
16.

Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).

Gauna C, van de Zande B, van Kerkwijk A, Themmen AP, van der Lely AJ, Delhanty PJ.

Mol Cell Endocrinol. 2007 Aug 15;274(1-2):30-4. Epub 2007 May 21.

PMID:
17601657
[PubMed - indexed for MEDLINE]
17.

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.

Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T.

Diabetes. 2006 Dec;55(12):3486-93.

PMID:
17130496
[PubMed - indexed for MEDLINE]
Free Article
18.

The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans.

Broglio F, Prodam F, Riganti F, Gottero C, Destefanis S, Granata R, Muccioli G, Abribat T, van der Lely AJ, Ghigo E.

J Endocrinol Invest. 2008 Sep;31(9):788-94.

PMID:
18997491
[PubMed - indexed for MEDLINE]
19.

Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans.

Benso A, St-Pierre DH, Prodam F, Gramaglia E, Granata R, van der Lely AJ, Ghigo E, Broglio F.

Eur J Endocrinol. 2012 May;166(5):911-6. doi: 10.1530/EJE-11-0982. Epub 2012 Feb 29.

PMID:
22379116
[PubMed - indexed for MEDLINE]
Free Article
20.

Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats.

Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M.

Endocrinology. 2006 May;147(5):2374-82. Epub 2006 Feb 2.

PMID:
16455774
[PubMed - indexed for MEDLINE]

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