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Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM.

Alonso R, López-Guerra M, Upshaw R, Bantia S, Smal C, Bontemps F, Manz C, Mehrling T, Villamor N, Campo E, Montserrat E, Colomer D.

Blood. 2009 Aug 20;114(8):1563-75. doi: 10.1182/blood-2009-02-207654. Epub 2009 Jun 18.


An essential role for p73 in regulating mitotic cell death.

Toh WH, Nam SY, Sabapathy K.

Cell Death Differ. 2010 May;17(5):787-800. doi: 10.1038/cdd.2009.181. Epub 2009 Dec 11.


Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

Ray RM, Bhattacharya S, Johnson LR.

Apoptosis. 2011 Jan;16(1):35-44. doi: 10.1007/s10495-010-0538-0.


SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.

Amin AR, Thakur VS, Paul RK, Feng GS, Qu CK, Mukhtar H, Agarwal ML.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5419-24. Epub 2007 Mar 16.


HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

Lau LM, Nugent JK, Zhao X, Irwin MS.

Oncogene. 2008 Feb 7;27(7):997-1003. Epub 2007 Aug 13.


c-Jun regulates the stability and activity of the p53 homologue, p73.

Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K.

J Biol Chem. 2004 Oct 22;279(43):44713-22. Epub 2004 Aug 9.


Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment.

Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, Yu Y, Zhou W, Li L, Feng J, Wang H, Zhu WG.

Neoplasia. 2009 Apr;11(4):313-24.


Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata.

Bhushan S, Malik F, Kumar A, Isher HK, Kaur IP, Taneja SC, Singh J.

Mol Carcinog. 2009 Dec;48(12):1093-108. doi: 10.1002/mc.20559.


FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.

Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW.

J Biol Chem. 2003 Dec 12;278(50):49795-805. Epub 2003 Oct 3.


RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.

Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y.

J Biol Chem. 2006 Feb 24;281(8):5267-76. Epub 2005 Dec 22.


Restoration of p53 functions protects cells from concanavalin A-induced apoptosis.

Amin AR, Thakur VS, Gupta K, Jackson MW, Harada H, Agarwal MK, Shin DM, Wald DN, Agarwal ML.

Mol Cancer Ther. 2010 Feb;9(2):471-9. doi: 10.1158/1535-7163.MCT-09-0732. Epub 2010 Feb 2.


Relief of p53-mediated telomerase suppression by p73.

Toh WH, Kyo S, Sabapathy K.

J Biol Chem. 2005 Apr 29;280(17):17329-38. Epub 2005 Feb 25.


Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates.

Li S, Zhou Y, Wang R, Zhang H, Dong Y, Ip C.

Mol Cancer Ther. 2007 Mar;6(3):1031-8. Epub 2007 Mar 5.


p73 expression and function in vestibular schwannoma.

Ahmad ZK, Altuna X, Lopez JP, An Y, Wang-Rodriguez J, Juneja VR, Chen JS, Arandazi MJ, Aguilera J, Harris JP, Ongkeko WM.

Arch Otolaryngol Head Neck Surg. 2009 Jul;135(7):662-9. doi: 10.1001/archoto.2009.79.


Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells.

Rana S, Gupta K, Gomez J, Matsuyama S, Chakrabarti A, Agarwal ML, Agarwal A, Agarwal MK, Wald DN.

FASEB J. 2010 Jun;24(6):2126-34. doi: 10.1096/fj.09-148999. Epub 2010 Feb 4.


p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death.

Crighton D, O'Prey J, Bell HS, Ryan KM.

Cell Death Differ. 2007 Jun;14(6):1071-9. Epub 2007 Feb 16.


The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis.

Holcakova J, Ceskova P, Hrstka R, Muller P, Dubska L, Coates PJ, Palecek E, Vojtesek B.

Cell Mol Biol Lett. 2008;13(3):404-20. doi: 10.2478/s11658-008-0011-z. Epub 2008 Mar 18.

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