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Items: 1 to 20 of 98

1.

The ubiquitin-specific protease USP28 is required for MYC stability.

Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.

Nat Cell Biol. 2007 Jul;9(7):765-74. Epub 2007 Jun 10.

PMID:
17558397
2.

MYC degradation: deubiquitinating enzymes enter the dance.

Amati B, Sanchez-Arévalo Lobo VJ.

Nat Cell Biol. 2007 Jul;9(7):729-31. No abstract available.

PMID:
17603505
3.

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.

Sun XX, He X, Yin L, Komada M, Sears RC, Dai MS.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3734-9. doi: 10.1073/pnas.1411713112. Epub 2015 Mar 9.

4.

Mechanisms of c-myc degradation by nickel compounds and hypoxia.

Li Q, Kluz T, Sun H, Costa M.

PLoS One. 2009 Dec 31;4(12):e8531. doi: 10.1371/journal.pone.0008531.

5.

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.

Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE.

Curr Biol. 2004 Oct 26;14(20):1852-7. Erratum in: Curr Biol. 2005 Dec;15(24):2285. Grim, Jonathan A [corrected to Grim, Jonathan E].

6.

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.

Popov N, Herold S, Llamazares M, Schülein C, Eilers M.

Cell Cycle. 2007 Oct 1;6(19):2327-31. Epub 2007 Jul 26.

PMID:
17873522
7.

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.

Otto T, Horn S, Brockmann M, Eilers U, Schüttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B, Eilers M.

Cancer Cell. 2009 Jan 6;15(1):67-78. doi: 10.1016/j.ccr.2008.12.005.

8.

CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.

Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Viñals F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, Uhlén M, Jirström K, Pontén F, Wohlschlegel J, Grandér D, Spruck C, Larsson LG, Sangfelt O.

EMBO Mol Med. 2013 Jul;5(7):999-1018. doi: 10.1002/emmm.201202341. Epub 2013 Jun 14.

10.

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.

Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E.

J Cell Biol. 2008 Jul 14;182(1):19-26. doi: 10.1083/jcb.200711040.

11.

Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells.

Chen XM, Xie XB, Zhao Q, Wang F, Bai Y, Yin JQ, Jiang H, Xie XL, Jia Q, Huang G.

Mol Med Rep. 2015 Jan;11(1):105-12. doi: 10.3892/mmr.2014.2733. Epub 2014 Oct 21.

12.

Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.

Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A.

Cancer Res. 2015 Apr 1;75(7):1181-6. doi: 10.1158/0008-5472.CAN-14-1726. Epub 2015 Feb 25.

13.

Implication of the ubiquitin/proteasome system in Myc-regulated transcription.

von der Lehr N, Johansson S, Larsson LG.

Cell Cycle. 2003 Sep-Oct;2(5):403-7. Review.

PMID:
12963825
14.

Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells.

Harnicarová A, Kozubek S, Pacherník J, Krejci J, Bártová E.

Exp Cell Res. 2006 Dec 10;312(20):4019-35. Epub 2006 Sep 16.

PMID:
17046748
15.

SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.

Jurado S, Díaz-Triviño S, Abraham Z, Manzano C, Gutierrez C, del Pozo C.

Plant J. 2008 Mar;53(5):828-41. Epub 2007 Nov 23.

16.

A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry.

Kishi T, Ikeda A, Koyama N, Fukada J, Nagao R.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14497-502. doi: 10.1073/pnas.0806253105. Epub 2008 Sep 11.

17.

Ubiquitin-specific protease 28 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity by regulating MYC expression.

Wang Z, Song Q, Xue J, Zhao Y, Qin S.

Exp Biol Med (Maywood). 2016 Feb;241(3):255-64. doi: 10.1177/1535370215595468. Epub 2015 Jul 23.

PMID:
26209720
18.
19.

Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549.

Chen XM, Bai Y, Zhong YJ, Xie XL, Long HW, Yang YY, Wu SG, Jia Q, Wang XH.

PLoS One. 2013 Nov 12;8(11):e79201. doi: 10.1371/journal.pone.0079201. eCollection 2013.

20.

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.

Diefenbacher ME, Popov N, Blake SM, Schülein-Völk C, Nye E, Spencer-Dene B, Jaenicke LA, Eilers M, Behrens A.

J Clin Invest. 2014 Aug;124(8):3407-18. doi: 10.1172/JCI73733. Epub 2014 Jun 24.

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