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Items: 1 to 20 of 106

1.

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques.

Hsieh MM, Linde NS, Wynter A, Metzger M, Wong C, Langsetmo I, Lin A, Smith R, Rodgers GP, Donahue RE, Klaus SJ, Tisdale JF.

Blood. 2007 Sep 15;110(6):2140-7. Epub 2007 Jun 8.

2.

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.

Biochem J. 2004 Aug 1;381(Pt 3):761-7.

3.

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.

Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R.

Brain Res. 2009 Jul 14;1280:43-51. doi: 10.1016/j.brainres.2009.05.023. Epub 2009 May 18.

PMID:
19450570
4.

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen ER, Arend M, Kivirikko KI, Koivunen P, Myllyharju J.

Blood. 2012 Oct 18;120(16):3336-44. doi: 10.1182/blood-2012-07-441824. Epub 2012 Sep 5.

5.

Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.

Kasiganesan H, Sridharan V, Wright G.

Acta Physiol (Oxf). 2007 Jun;190(2):163-9. Epub 2007 Mar 30.

PMID:
17394573
6.

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH.

Blood. 2008 Mar 15;111(6):3229-35. Epub 2007 Dec 4.

7.

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

Bernhardt WM, Wiesener MS, Scigalla P, Chou J, Schmieder RE, Günzler V, Eckardt KU.

J Am Soc Nephrol. 2010 Dec;21(12):2151-6. doi: 10.1681/ASN.2010010116. Epub 2010 Nov 29.

8.
9.

Vanadate elevates fetal hemoglobin in human erythroid precursors by inhibiting cell maturation.

Amoyal I, Prus E, Fibach E.

Exp Biol Med (Maywood). 2007 May;232(5):654-61.

PMID:
17463162
10.

The HIF pathway and erythrocytosis.

Lee FS, Percy MJ.

Annu Rev Pathol. 2011;6:165-92. doi: 10.1146/annurev-pathol-011110-130321. Review.

PMID:
20939709
11.

Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition.

Bussolati B, Lauritano C, Moggio A, Collino F, Mazzone M, Camussi G.

J Am Soc Nephrol. 2013 Jul;24(8):1234-41. doi: 10.1681/ASN.2012080772. Epub 2013 May 9.

12.

Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells.

Grek CL, Newton DA, Spyropoulos DD, Baatz JE.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):439-47. doi: 10.1165/rcmb.2009-0307OC. Epub 2010 May 27.

13.

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy in the rat 50/10 model.

Trichonas G, Lee TJ, Hoppe G, Au J, Sears JE.

Invest Ophthalmol Vis Sci. 2013 Jul 22;54(7):4919-26. doi: 10.1167/iovs.13-12171.

PMID:
23761085
14.

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

Wang Z, Schley G, Türkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU, Bernhardt WM.

Nephrol Dial Transplant. 2012 Mar;27(3):929-36. doi: 10.1093/ndt/gfr379. Epub 2011 Jul 8.

15.

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.

Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20.

16.

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Tröger J, Barth S, Camenisch G, Wenger RH.

Blood. 2005 Jun 15;105(12):4613-9. Epub 2005 Mar 1.

17.

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.

Furlow PW, Percy MJ, Sutherland S, Bierl C, McMullin MF, Master SR, Lappin TR, Lee FS.

J Biol Chem. 2009 Apr 3;284(14):9050-8. doi: 10.1074/jbc.M808737200. Epub 2009 Feb 10.

19.

Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression.

Stockmann C, Fandrey J.

Clin Exp Pharmacol Physiol. 2006 Oct;33(10):968-79. Review.

PMID:
17002676
20.

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.

Percy MJ, Furlow PW, Beer PA, Lappin TR, McMullin MF, Lee FS.

Blood. 2007 Sep 15;110(6):2193-6. Epub 2007 Jun 19.

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