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Items: 1 to 20 of 184

1.

Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.

Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, Orr HT.

J Neurochem. 2007 Sep;102(6):2040-8. Epub 2007 Jun 1.

2.

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.

Emamian ES, Kaytor MD, Duvick LA, Zu T, Tousey SK, Zoghbi HY, Clark HB, Orr HT.

Neuron. 2003 May 8;38(3):375-87.

3.

Phosphorylation of ATXN1 at Ser776 in the cerebellum.

Jorgensen ND, Andresen JM, Lagalwar S, Armstrong B, Stevens S, Byam CE, Duvick LA, Lai S, Jafar-Nejad P, Zoghbi HY, Clark HB, Orr HT.

J Neurochem. 2009 Jul;110(2):675-86. doi: 10.1111/j.1471-4159.2009.06164.x. Epub 2009 May 15.

4.

Biomedicine. Ataxin-1 regulators in the spotlight.

Heintz N.

Science. 2003 Jul 4;301(5629):59-60. No abstract available.

PMID:
12843383
5.

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product.

Hong S, Ka S, Kim S, Park Y, Kang S.

Biochim Biophys Acta. 2003 May 20;1638(1):35-42.

6.

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY.

Cell. 2003 May 16;113(4):457-68.

7.

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

Cummings CJ, Mancini MA, Antalffy B, DeFranco DB, Orr HT, Zoghbi HY.

Nat Genet. 1998 Jun;19(2):148-54.

PMID:
9620770
8.

Identification of a novel phosphorylation site in ataxin-1.

Vierra-Green CA, Orr HT, Zoghbi HY, Ferrington DA.

Biochim Biophys Acta. 2005 May 15;1744(1):11-8. Epub 2004 Nov 10.

9.
10.

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.

Gehrking KM, Andresen JM, Duvick L, Lough J, Zoghbi HY, Orr HT.

Hum Mol Genet. 2011 Jun 1;20(11):2204-12. doi: 10.1093/hmg/ddr108. Epub 2011 Mar 22.

11.

Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model.

Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ.

Cerebellum. 2014 Oct;13(5):596-606. doi: 10.1007/s12311-014-0576-1.

PMID:
24930030
13.

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, Clark HB, Zoghbi HY, Orr HT.

Cell. 1998 Oct 2;95(1):41-53.

14.

14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus.

Lai S, O'Callaghan B, Zoghbi HY, Orr HT.

J Biol Chem. 2011 Oct 7;286(40):34606-16. doi: 10.1074/jbc.M111.238527. Epub 2011 Aug 11. Erratum in: J Biol Chem. 2013 Mar 1;288(9):6590.

15.

USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.

Hong S, Kim SJ, Ka S, Choi I, Kang S.

Mol Cell Neurosci. 2002 Jun;20(2):298-306.

PMID:
12093161
16.

SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic mice.

Kang S, Hong S.

Arch Ital Biol. 2010 Dec;148(4):351-63. doi: 10.4449/aib.v148i4.1201.

PMID:
21308649
17.

A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.

Sánchez I, Piñol P, Corral-Juan M, Pandolfo M, Matilla-Dueñas A.

Hum Mol Genet. 2013 Sep 1;22(17):3425-37. doi: 10.1093/hmg/ddt197. Epub 2013 Apr 29.

18.

SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.

Duvick L, Barnes J, Ebner B, Agrawal S, Andresen M, Lim J, Giesler GJ, Zoghbi HY, Orr HT.

Neuron. 2010 Sep 23;67(6):929-35. doi: 10.1016/j.neuron.2010.08.022.

19.

Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.

Hearst SM, Lopez ME, Shao Q, Liu Y, Vig PJ.

J Neurochem. 2010 Aug;114(3):706-16. doi: 10.1111/j.1471-4159.2010.06791.x. Epub 2010 Apr 30.

20.

SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.

Orr HT.

Prog Neurobiol. 2012 Dec;99(3):179-85. doi: 10.1016/j.pneurobio.2012.04.003. Epub 2012 Apr 16. Review.

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