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Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.

Javvadi P, Makino H, Das AK, Lin YF, Chen DJ, Chen BP, Nirodi CS.

Mol Cancer Res. 2012 Oct;10(10):1359-68. doi: 10.1158/1541-7786.MCR-12-0482-T. Epub 2012 Aug 23.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA.

J Biol Chem. 2004 Sep 17;279(38):39408-13. Epub 2004 Jul 15.


Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.

Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP.

Nucleic Acids Res. 2004 Aug 16;32(14):4351-7. Print 2004.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.


Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Yoon JH, Ahn SG, Lee BH, Jung SH, Oh SH.

Biochem Pharmacol. 2012 Mar 15;83(6):747-57. doi: 10.1016/j.bcp.2011.12.029. Epub 2011 Dec 29.


Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, Chen DJ.

J Biol Chem. 2007 Mar 2;282(9):6582-7. Epub 2006 Dec 21.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells].

Zhuang L, Yu SY, Huang XY, Cao Y, Xiong HH.

Ai Zheng. 2007 Jul;26(7):724-9. Chinese.


Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ.

J Biol Chem. 2005 Apr 15;280(15):14709-15. Epub 2005 Jan 26.


Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP.

Mol Cell Biol. 2010 Mar;30(6):1368-81. doi: 10.1128/MCB.00741-09. Epub 2010 Jan 11.


Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.

Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK.

Cancer Res. 2010 May 1;70(9):3657-66. doi: 10.1158/0008-5472.CAN-09-3362. Epub 2010 Apr 20.


Protein phosphatases regulate DNA-dependent protein kinase activity.

Douglas P, Moorhead GB, Ye R, Lees-Miller SP.

J Biol Chem. 2001 Jun 1;276(22):18992-8. Epub 2001 Mar 16.


The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain.

Douglas P, Cui X, Block WD, Yu Y, Gupta S, Ding Q, Ye R, Morrice N, Lees-Miller SP, Meek K.

Mol Cell Biol. 2007 Mar;27(5):1581-91. Epub 2006 Dec 11.


ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.

Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen DJ, Ohnishi K, Ohnishi T.

J Radiat Res. 2010;51(4):417-22. Epub 2010 Apr 24.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.

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