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Items: 1 to 20 of 83

1.

Protective effects of the sigma agonist Pre-084 in the rat retina.

Cantarella G, Bucolo C, Di Benedetto G, Pezzino S, Lempereur L, Calvagna R, Clementi S, Pavone P, Fiore L, Bernardini R.

Br J Ophthalmol. 2007 Oct;91(10):1382-4. Epub 2007 May 23.

2.

Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion.

Antonini V, Marrazzo A, Kleiner G, Coradazzi M, Ronsisvalle S, Prezzavento O, Ronsisvalle G, Leanza G.

J Alzheimers Dis. 2011;24(3):569-86. doi: 10.3233/JAD-2011-101794.

PMID:
21297260
3.

Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.

Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Lee JH.

J Neurosci Res. 2008 Dec;86(16):3644-54. doi: 10.1002/jnr.21802.

PMID:
18655205
4.

sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation.

Tchedre KT, Yorio T.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2577-88. doi: 10.1167/iovs.07-1101. Epub 2008 Feb 22.

PMID:
18296662
5.

The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action.

Tan F, Guio-Aguilar PL, Downes C, Zhang M, O'Donovan L, Callaway JK, Crack PJ.

Neuropharmacology. 2010 Nov;59(6):416-24. doi: 10.1016/j.neuropharm.2010.05.014. Epub 2010 Jun 9.

PMID:
20538010
6.

Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina.

Ju WK, Lindsey JD, Angert M, Patel A, Weinreb RN.

Mol Vis. 2008;14:2629-38. Epub 2008 Dec 31.

7.

Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.

Guzmán-Lenis MS, Navarro X, Casas C.

Neuroscience. 2009 Aug 4;162(1):31-8. doi: 10.1016/j.neuroscience.2009.03.067. Epub 2009 Apr 5.

PMID:
19345724
8.

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.

Shen YC, Wang YH, Chou YC, Liou KT, Yen JC, Wang WY, Liao JF.

J Neurochem. 2008 Jan;104(2):558-72. doi: 10.1111/j.1471-4159.2007.05058.x.

9.

A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors.

Bucolo C, Marrazzo A, Ronsisvalle S, Ronsisvalle G, Cuzzocrea S, Mazzon E, Caputi A, Drago F.

Eur J Pharmacol. 2006 Apr 24;536(1-2):200-3. Epub 2006 Mar 6.

PMID:
16580663
10.

Amylin prevents TRAIL-mediated apoptotic effects of reserpine in the rat gastric mucosa.

Cantarella G, Di Benedetto G, Martinez G, Loreto C, Clementi G, Cantarella A, Prato A, Bernardini R.

Peptides. 2009 Aug;30(8):1466-72. doi: 10.1016/j.peptides.2009.05.005. Epub 2009 May 20.

PMID:
19463876
11.

Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures.

Zhang Y, Shi Y, Qiao L, Sun Y, Ding W, Zhang H, Li N, Chen D.

Brain Res. 2012 Jan 11;1431:13-22. doi: 10.1016/j.brainres.2011.10.053. Epub 2011 Nov 6.

PMID:
22133307
12.

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.

Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G.

Neuroreport. 2005 Aug 1;16(11):1223-6.

PMID:
16012353
13.

Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.

Kim HW, Roh DH, Yoon SY, Seo HS, Kwon YB, Han HJ, Kim KW, Beitz AJ, Lee JH.

Br J Pharmacol. 2008 Jul;154(5):1125-34. doi: 10.1038/bjp.2008.159. Epub 2008 May 19.

14.

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

Harper N, Hughes MA, Farrow SN, Cohen GM, MacFarlane M.

J Biol Chem. 2003 Nov 7;278(45):44338-47. Epub 2003 Aug 14.

15.

Sigma receptor ligands protect human retinal cells against oxidative stress.

Bucolo C, Drago F, Lin LR, Reddy VN.

Neuroreport. 2006 Feb 27;17(3):287-91.

PMID:
16462599
16.

Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain.

Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH.

Anesthesiology. 2008 Nov;109(5):879-89. doi: 10.1097/ALN.0b013e3181895a83.

PMID:
18946301
17.

Oxaliplatin sensitizes human colon cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL.

El Fajoui Z, Toscano F, Jacquemin G, Abello J, Scoazec JY, Micheau O, Saurin JC.

Gastroenterology. 2011 Aug;141(2):663-73. doi: 10.1053/j.gastro.2011.04.055. Epub 2011 Apr 30.

PMID:
21683075
18.

Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema.

Morissette MC, Vachon-Beaudoin G, Parent J, Chakir J, Milot J.

Am J Respir Crit Care Med. 2008 Aug 1;178(3):240-7. doi: 10.1164/rccm.200710-1486OC. Epub 2008 May 29.

PMID:
18511705
19.

Activation of somatostatin receptor (sst 5) protects the rat retina from AMPA-induced neurotoxicity.

Kiagiadaki F, Savvaki M, Thermos K.

Neuropharmacology. 2010 Jan;58(1):297-303. doi: 10.1016/j.neuropharm.2009.06.028. Epub 2009 Jul 2.

PMID:
19576912
20.

Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension.

Sun X, Cheng F, Meng B, Yang B, Song W, Yuan H.

Mol Biol Rep. 2012 Jun;39(6):6607-14. doi: 10.1007/s11033-012-1491-5. Epub 2012 Feb 7.

PMID:
22311017
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